Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

Kano,Yoshihiro; Ishii,Hideshi; Konno,Masamitsu; Yamasaki,Makoto; Miyata,Hiroshi; Nishikawa,Shimpei; Hamabe,Atsushi; Ogawa,Hisataka; Takahashi,Hidekazu; Ohta,Katsuya; Hasegawa,Shinichiro; Tanaka,Kouji; Fukusumi,Takahito; Otsuka,Masahisa; Kawamoto,Koichi; Haraguchi,Naotsugu; Fujimoto,Rika; Isobe,Masaharu; Tomita,Yasuhiko; Matsuura,Nariaki; Takiguchi,Shuji; Mori,Masaki; Doki,Yuichiro

doi:10.3892/ijo.2013.2206

2014-February Volume 44 Issue 2

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2014-February Volume 44 Issue 2

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Article

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

Authors:
- Yoshihiro Kano
- Hideshi Ishii
- Masamitsu Konno
- Makoto Yamasaki
- Hiroshi Miyata
- Shimpei Nishikawa
- Atsushi Hamabe
- Hisataka Ogawa
- Hidekazu Takahashi
- Katsuya Ohta
- Shinichiro Hasegawa
- Kouji Tanaka
- Takahito Fukusumi
- Masahisa Otsuka
- Koichi Kawamoto
- Naotsugu Haraguchi
- Rika Fujimoto
- Masaharu Isobe
- Yasuhiko Tomita
- Nariaki Matsuura
- Shuji Takiguchi
- Masaki Mori
- Yuichiro Doki
View Affiliations / Copyright

Affiliations: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan, Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan, Laboratory of Molecular and Cellular Biology, Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Toyama, Japan, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, Department of Functional Diagnostic Science, Osaka University, Graduate School of Medicine, Osaka, Japan
Pages: 443-450
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Published online on: December 3, 2013

https://doi.org/10.3892/ijo.2013.2206
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Abstract

Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor‑derived epithelial cells but also donor-derived secondary solid tumors have also been reported in mice and humans. It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. In most reports of donor-derived secondary solid tumors, however, tumors contained a low proportion of BMDC-derived epithelial cells in mixed solid tumor tissues. To our knowledge, there are only five known cases of completely donor-derived tumor tissues, i.e., four oral SCCs and a pharyngeal SCC. In this study, we analyzed five human clinical samples of solid tumors, i.e., two esophageal squamous cell carcinomas (SCCs), two oral SCCs and a tongue carcinoma. In the oral and tongue, completely donor-derived tissues were not observed, but in esophagus a completely donor-derived esophageal epidermis and SCC were observed for the first time. In addition, in another esophageal SCC patient, a completely donor-derived dysplasia region of esophageal epidermis was observed near recipient-derived SCC. This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

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