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Article

TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation

  • Authors:
    • Oh-Hyung Kwon
    • Jong Hwan Kim
    • Seon-Young Kim
    • Yong Sung Kim
  • View Affiliations / Copyright

    Affiliations: Medical Genomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea
  • Pages: 583-590
    |
    Published online on: December 9, 2013
       https://doi.org/10.3892/ijo.2013.2211
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Abstract

Chemoresistance is one of the most serious problems in the treatment of cancer. In the present study, we show that Fn14 promotes resistance to 5-fluorouracil (5-FU) in gastric cancer (GC). We found that 5-FU treatment upregulated Fn14 expression in various cancer cell lines, including GC cell lines, and that knockdown of Fn14 using shRNA accelerated 5-FU sensitivity. In contrast, Fn14 overexpression or TWEAK treatment promoted resistance to 5-FU. Furthermore, we investigated the mechanisms underlying Fn14-mediated chemoresistance. We first revealed that 5-FU-mediated upregulation of Fn14 occurred as a result of NF-κB activation, indicating that 5-FU-mediated NF-κB activation was the principal event underlying Fn14 upregulation and 5-FU resistance in GC. Taken together, our results suggest that Fn14 is a novel therapeutic target and that inhibition of Fn14 combined with 5-FU treatment may be an effective molecular therapeutic strategy to treat 5-FU-resistant gastric cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Kwon O, Kim JH, Kim S and Kim YS: TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation. Int J Oncol 44: 583-590, 2014.
APA
Kwon, O., Kim, J.H., Kim, S., & Kim, Y.S. (2014). TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation. International Journal of Oncology, 44, 583-590. https://doi.org/10.3892/ijo.2013.2211
MLA
Kwon, O., Kim, J. H., Kim, S., Kim, Y. S."TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation". International Journal of Oncology 44.2 (2014): 583-590.
Chicago
Kwon, O., Kim, J. H., Kim, S., Kim, Y. S."TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation". International Journal of Oncology 44, no. 2 (2014): 583-590. https://doi.org/10.3892/ijo.2013.2211
Copy and paste a formatted citation
x
Spandidos Publications style
Kwon O, Kim JH, Kim S and Kim YS: TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation. Int J Oncol 44: 583-590, 2014.
APA
Kwon, O., Kim, J.H., Kim, S., & Kim, Y.S. (2014). TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation. International Journal of Oncology, 44, 583-590. https://doi.org/10.3892/ijo.2013.2211
MLA
Kwon, O., Kim, J. H., Kim, S., Kim, Y. S."TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation". International Journal of Oncology 44.2 (2014): 583-590.
Chicago
Kwon, O., Kim, J. H., Kim, S., Kim, Y. S."TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation". International Journal of Oncology 44, no. 2 (2014): 583-590. https://doi.org/10.3892/ijo.2013.2211
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