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Molecular profiling of chordoma

  • Authors:
    • Stefanie Scheil-Bertram
    • Roland Kappler
    • Alexandra von Baer
    • Erich Hartwig
    • Michael Sarkar
    • Massimo Serra
    • Silke Brüderlein
    • Bettina Westhoff
    • Ingo Melzner
    • Birgit Bassaly
    • Jochen Herms
    • Heinz-Hermann Hugo
    • Michael Schulte
    • Peter Möller
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, University Hospitals of Ulm, Germany, Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilian University of Munich, Munich, Germany, Department of Orthopedic Trauma, Hand and Reconstructive Surgery, University Hospitals of Ulm, Germany, Department of Trauma, Hand and Reconstructive Surgery, Ev. Diakonissenanstalt, Karlsruhe, Germany, Department of Trauma and Reconstructive Surgery, Karl-Olga-Krankenhaus, Stuttgart, Germany, Laboratory of Experimental Oncology, Orthopedic Rizzoli Institute, Bologna, Italy, Department of Orthopedics, University of Düsseldorf, Germany, Institute of Pathology, University of Giessen, Germany, Department of Translational Brain Research, DZNE (German Center for Neurodegenerative Diseases) and Ludwig-Maximilian University of Munich, Munich, Germany, Department of Neurosurgery, University of Kiel, Kiel, Germany, Department of Trauma and Orthopedic Surgery, Diakoniekrankenhaus, Rotenburg (Wümme), Germany
    Copyright: © Scheil-Bertram et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1041-1055
    |
    Published online on: January 21, 2014
       https://doi.org/10.3892/ijo.2014.2268
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Abstract

The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-density oligonucleotide array. The expression of 65 genes whose mRNA levels differed significantly (p<0.001; ≥6-fold change) between chordoma and control (vertebral disc) was identified. Genes with increased expression in chordoma compared to control and chondrosarcoma were most frequently located on chromosomes 2 (11%), 5 (8%), 1 and 7 (each 6%), whereas interphase cytogenetics of 33 chordomas demonstrated gains of chromosomal material most prevalent on 7q (42%), 12q (21%), 17q (21%), 20q (27%) and 22q (21%). The microarray data were confirmed for selected genes by quantitative polymerase chain reaction analysis. As in other studies, we showed the expression of brachyury. We demonstrate the expression of new potential candidates for chordoma tumorigenesis, such as CD24, ECRG4, RARRES2, IGFBP2, RAP1, HAI2, RAB38, osteopontin, GalNAc-T3, VAMP8 and others. Thus, we identified and validated a set of interesting candidate genes whose differential expression likely plays a role in chordoma.
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View References

1. 

Dorfman HD and Czerniak B: Bone tumors. Mosby; St. Louis, MO: 1998

2. 

Mirra JM, Nelson SD, Della Rocca C and Mertens F: Chordoma. Pathology and Genetics of Tumors of Soft Tissue and Bone World Health Organization Classification of Tumors. Fletcher CDM, Unni KK and Mertens F: IARC Press; Lyon: pp. 316–317. 2002

3. 

Dewaele B, Maggiani F, Floris G, Ampe M, Vanspauwen V, Wozniak A, Debiec-Rychter M and Sciot R: Frequent activation of EGFR in advanced chordomas. Clin Sarcoma Res. 25:42011. View Article : Google Scholar : PubMed/NCBI

4. 

Diaz RJ, Guduk M, Romagnuolo R, Smith CA, Northcott P, Shih D, Berisha F, Flanagan A, Munoz DG, Cusimano MD, Pamir MN and Rutka JT: High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis. Neoplasia. 14:788–798. 2012.PubMed/NCBI

5. 

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC and Flanagan AM: Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/ brachyury signalling pathway in chordomas. Mod Pathol. 22:996–1005. 2009. View Article : Google Scholar : PubMed/NCBI

6. 

Stacchiotti S, Tamborini E, Lo Vullo S, Bozzi F, Messina A, Morosi C, Casale A, Crippa F, Conca E, Negri T, Palassini E, Marrari A, Palmerini E, Mariani L, Gronchi A, Pilotti S and Casali PG: Phase II study on lapatinib in advanced EGFR-positive chordoma. Ann Oncol. 24:1931–1936. 2013. View Article : Google Scholar : PubMed/NCBI

7. 

Scheil S, Bruederlein S, Liehr T, Starke H, Herms J, Schulte M and Moeller P: Genome wide analysis of 16 chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1. Genes Chromosomes Cancer. 32:203–211. 2001. View Article : Google Scholar : PubMed/NCBI

8. 

Larizza L, Mortini P and Riva P: Update on the cytogenetics and molecular genetics of chordoma. Hered Cancer Clin Pract. 3:29–41. 2005. View Article : Google Scholar : PubMed/NCBI

9. 

Kelley MJ, Korczak JF, Sheridan E, Yang X, Goldstein AM and Parry DM: Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. Am J Hum Genet. 69:454–460. 2001. View Article : Google Scholar : PubMed/NCBI

10. 

Szuhai K and Hogendoorn PC: ‘The chicken or the egg?’ dilemma strikes back for the controlling mechanism in chordoma. J Pathol. 228:261–265. 2012.

11. 

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K and Flanagan AM: Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study. J Pathol. 223:327–335. 2011. View Article : Google Scholar : PubMed/NCBI

12. 

Bruederlein S, Sommer JB, Meltzer PS, Li S, Osada T, Ng D, Möller P, Alcorta DA and Kelley MJ: Molecular characterization of putative chordoma cell lines. Sarcoma. 2010:6301292010.PubMed/NCBI

13. 

Fisher LW, Hawkins GR, Tuross N and Termine JD: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. J Biol Chem. 262:9702–9708. 1987.PubMed/NCBI

14. 

Straeter J, Walczak H, Pukrop T, von Müller L, Hasel C, Kornmann M, Mertens T and Möller P: TRAIL and is receptors in the colonic epithelium: a putative role in the defense of viral infections. Gastroenterology. 122:659–666. 2002. View Article : Google Scholar : PubMed/NCBI

15. 

Gisselsson D, Pålsson E, Höglund M, Domanski H, Mertens F, Pandis N, Sciot R, Dal Cin P, Bridge JA and Mandahl N: Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. Genes Chromosomes Cancer. 33:133–140. 2002. View Article : Google Scholar : PubMed/NCBI

16. 

Van Gelder RN, von Zastrow ME, Yool A, Dement WC, Barchas JD and Eberwine JH: Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc Natl Acad Sci USA. 87:1663–1667. 1990.PubMed/NCBI

17. 

Kappler R, Hess I, Schlegel J and Hahn H: Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma. Int J Oncol. 25:113–120. 2004.PubMed/NCBI

18. 

Ruiz I, Altaba A, Sánchez P and Dahmane N: Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer. 2:361–372. 2002. View Article : Google Scholar : PubMed/NCBI

19. 

Kappler R, Calzada-Wack J, Schnitzbauer U, Koleva M, Herwig A, Piontek G, Graedler F, Adamski J, Heinzmann U, Schlegel J, Hemmerlein B, Quintanilla-Martinez L and Hahn H: Molecular characterization of Patched-associated rhabdomyosarcoma. J Pathol. 200:348–356. 2003. View Article : Google Scholar : PubMed/NCBI

20. 

Hallor KH, Staaf J, Jönsson G, Heidenblad M, Vult von Steyern F, Bauer HC, Ijszenga M, Hogendoorn PC, Mandahl N, Szuhai K and Mertens F: Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation. Br J Cancer. 98:434–442. 2008. View Article : Google Scholar

21. 

Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ and Iafrate AJ: Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One. 6:e188462011. View Article : Google Scholar : PubMed/NCBI

22. 

Rittling SR and Chambers AF: Role of ostopontin in tumour progression. Br J Cancer. 17:1877–1881. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Otto WR and Rao J: Tomorrow’s skeleton staff: mesenchymal stem cells and the repair of bone and cartilage. Cell Prolif. 37:97–110. 2004.

24. 

Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA and Sowden J: The human homolog T of the mouse T (Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res. 6:226–233. 1996. View Article : Google Scholar : PubMed/NCBI

25. 

Hsu W, Mohyeldin A, Shah SR, Ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL and Quiñones-Hinojosa A: Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target. J Neurosurg. 115:760–769. 2011. View Article : Google Scholar : PubMed/NCBI

26. 

Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM and Kelley MJ: T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 41:1176–1178. 2009. View Article : Google Scholar : PubMed/NCBI

27. 

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC and Flanagan AM: An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. J Pathol. 228:274–285. 2012. View Article : Google Scholar : PubMed/NCBI

28. 

Launay SG, Chetaille B, Medina F, Perrot D, Nazarian S, Guiramand J, Moureau-Zabotto L and Bertucci F: Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review. BMC Cancer. 11:4232011. View Article : Google Scholar : PubMed/NCBI

29. 

Kristiansen G, Winzer KJ, Mayordomo E, Bellach J, Schluns K, Denkert C, Dahl E, Pilarsky C, Altevogt P, Guski H and Dietel M: CD24 expression is a new prognostic marker in breast cancer. Clin Cancer Res. 9:4909–4913. 2004.

30. 

Kristiansen G, Pilarsky C, Pervan J, Sturzebecher B, Stephan C, Jung K, Loening S, Rosenthal A and Dietel M: CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer. Prostate. 58:183–192. 2004. View Article : Google Scholar : PubMed/NCBI

31. 

Sabatier R, Finetti P, Adelaide J, Guille A, Borg JP, Chaffanet M, Lane J, Birnbaum D and Bertucci F: Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS One. 6:e276562011. View Article : Google Scholar : PubMed/NCBI

32. 

Su T, Liu H and Lu S: Cloning and identification of cDNA fragments related to human esophageal cancer. China J Oncol. 20:254–257. 1998.(In Chinese).

33. 

Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, Birney E, Rosenthal N and Gross C: Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Genome Res. 17:320–327. 2007. View Article : Google Scholar : PubMed/NCBI

34. 

Chen C, Yang HL, Chen KW, Wang GL, Lu J, Yuan Q, Gu YP and Luo ZP: High expression of survivin in sacral chordoma. Med Oncol. 30:5292013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Bassaly B, et al: Molecular profiling of chordoma. Int J Oncol 44: 1041-1055, 2014.
APA
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M. ... Möller, P. (2014). Molecular profiling of chordoma. International Journal of Oncology, 44, 1041-1055. https://doi.org/10.3892/ijo.2014.2268
MLA
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M., Brüderlein, S., Westhoff, B., Melzner, I., Bassaly, B., Herms, J., Hugo, H., Schulte, M., Möller, P."Molecular profiling of chordoma". International Journal of Oncology 44.4 (2014): 1041-1055.
Chicago
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M., Brüderlein, S., Westhoff, B., Melzner, I., Bassaly, B., Herms, J., Hugo, H., Schulte, M., Möller, P."Molecular profiling of chordoma". International Journal of Oncology 44, no. 4 (2014): 1041-1055. https://doi.org/10.3892/ijo.2014.2268
Copy and paste a formatted citation
x
Spandidos Publications style
Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Bassaly B, et al: Molecular profiling of chordoma. Int J Oncol 44: 1041-1055, 2014.
APA
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M. ... Möller, P. (2014). Molecular profiling of chordoma. International Journal of Oncology, 44, 1041-1055. https://doi.org/10.3892/ijo.2014.2268
MLA
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M., Brüderlein, S., Westhoff, B., Melzner, I., Bassaly, B., Herms, J., Hugo, H., Schulte, M., Möller, P."Molecular profiling of chordoma". International Journal of Oncology 44.4 (2014): 1041-1055.
Chicago
Scheil-Bertram, S., Kappler, R., von Baer, A., Hartwig, E., Sarkar, M., Serra, M., Brüderlein, S., Westhoff, B., Melzner, I., Bassaly, B., Herms, J., Hugo, H., Schulte, M., Möller, P."Molecular profiling of chordoma". International Journal of Oncology 44, no. 4 (2014): 1041-1055. https://doi.org/10.3892/ijo.2014.2268
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