[Erratum] Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo

Vannucci,Luca; Fiserová,Anna; Sadalapure,Kashinath; Lindhorst,Thisbe K.; Kuldová,Marketa; Rossmann,Pavel; Horváth,Ondrej; Kren,Vladimir; Krist,Pavel; Bezouska,Karel; Luptovcová,Martina; Mosca,Franco; Pospísil,Miloslav

doi:10.3892/ijo.2014.2288

2014-April Volume 44 Issue 4

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Correction Open Access

[Erratum] Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo

Authors:
- Luca Vannucci
- Anna Fiserová
- Kashinath Sadalapure
- Thisbe K. Lindhorst
- Marketa Kuldová
- Pavel Rossmann
- Ondrej Horváth
- Vladimir Kren
- Pavel Krist
- Karel Bezouska
- Martina Luptovcová
- Franco Mosca
- Miloslav Pospísil
View Affiliations / Copyright

Affiliations: Laboratory of Natural Cell Immunity, Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic, Institute of Microbiology, Czech Academy of Sciences, 14220 Prague 4, Czech Republic, Institute of Organic Chemistry, Christiana-Albertina University of Kiel, Kiel, Germany, Institute of Molecular Genetics, Czech Academy of Sciences, 12840 Prague 2, Czech Republic, Department of Oncology, Transplantation and New Technologies in Medicine, University of Pisa, 1-56124 Pisa, Italy

Copyright: © Vannucci et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 1410-1410
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Published online on: February 3, 2014

https://doi.org/10.3892/ijo.2014.2288
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Article

According to new data in literature related to the above article (http://dx.doi.org./10.1016/j.imlet.2013.09.009; http://www.mdpi.com/1422-0067/15/1/1271) following a re-evaluation of controversial results of Professor K. Bezouska on NKR-P1 (rat and mouse receptors) interactions with carbohydrates, we need to correct some statements of this paper and the interpretation of some results consequent to these statements (which were based on published data by Professor K. Bezouska considered still valid at the time of preparation and publication of this paper).

At present, we need to consider the following statment as erroneous:

- the NKR-P1 receptor is a high affinity receptor for various oligosaccharides which were considered mimetics of putative ligands for this receptor (as previously reported in literature);

- PAMAM-GlcNAc8 glycodendrimer has high affinity and selectivity for the NKR-P1 receptor.

Instead, the effects of PAMAM-GlcNAc8 reported in this paper, modulating the tumor biology and immune response, have to be re-interpreted: as the result of not exclusive interaction of glycodendrimers with NKR-P1 receptor and NK cells but as the possible result of interactions with a wider panel of cells and receptors of innate immunity to be better clarified (as already suggested at the end of the Discussion and in the conclusions of this paper).