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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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2014-April Volume 44 Issue 4

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Article Open Access

Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma

  • Authors:
    • Wenxi Yu
    • Lina Tang
    • Feng Lin
    • Dake Li
    • Jun Wang
    • Yao Yang
    • Zan Shen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Xuhui, 200233 Shanghai, P.R. China, Department of Gynecology and Obstetrics, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, 210029 Nanjing, P.R. China, Department of First General Surgery, People's Hospital of Ma An Shan, Ma An Shan, Anhui, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1091-1098
    |
    Published online on: February 10, 2014
       https://doi.org/10.3892/ijo.2014.2295
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Abstract

Stereotactic radiosurgery (SRS), such as body gamma knife, was reported to achieve excellent rates of local disease control with limited toxicity in many cases of primary or secondary pulmonary tumor, except osteosarcoma. To confirm the value of SRS in pulmonary metastases from osteosarcoma, we reviewed the experience from our institution (Department of Oncology, Affiliated Sixth People's Hospital, Shanghai) and compared the efficiency of SRS with that of surgical resection. From January 2005 to December 2012, we carried out a retrospective investigation of 58 patients (age, 8-59 years; mean, 25.2 years) who were diagnosed with non-metastatic osteosarcoma of the extremity and later developed pulmonary metastasis during the period of adjuvant chemotherapy or follow-up. Among them, 27 patients were treated by SRS using the body gamma-knife system. A total dose of 50 Gy was delivered at 5 Gy/fraction to the 50% isodose line covering the planning target volume, whereas a total dose of 70 Gy was delivered at 7 Gy/fraction to the gross target volume. The other 31 patients were treated by surgical resection. Two-year progression-free survival rate, two-year survival rate, median time of PRPFS (post-relapse progress-free survival) and PROS (post-relapse overall survival) in SRS group were parallel to that in surgical group. All 27 patients tolerated gamma knife radiosurgery well while only 9 patients had grades 1-2 pneumonitis. We believe SRS, compared with surgical resection, is effective and safe in treating pulmonary metastasis from osteosarcoma, especially for those patients who were medically unfit for a resection or who refused surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Yu W, Tang L, Lin F, Li D, Wang J, Yang Y and Shen Z: Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma. Int J Oncol 44: 1091-1098, 2014.
APA
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., & Shen, Z. (2014). Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma. International Journal of Oncology, 44, 1091-1098. https://doi.org/10.3892/ijo.2014.2295
MLA
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., Shen, Z."Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma". International Journal of Oncology 44.4 (2014): 1091-1098.
Chicago
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., Shen, Z."Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma". International Journal of Oncology 44, no. 4 (2014): 1091-1098. https://doi.org/10.3892/ijo.2014.2295
Copy and paste a formatted citation
x
Spandidos Publications style
Yu W, Tang L, Lin F, Li D, Wang J, Yang Y and Shen Z: Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma. Int J Oncol 44: 1091-1098, 2014.
APA
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., & Shen, Z. (2014). Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma. International Journal of Oncology, 44, 1091-1098. https://doi.org/10.3892/ijo.2014.2295
MLA
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., Shen, Z."Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma". International Journal of Oncology 44.4 (2014): 1091-1098.
Chicago
Yu, W., Tang, L., Lin, F., Li, D., Wang, J., Yang, Y., Shen, Z."Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma". International Journal of Oncology 44, no. 4 (2014): 1091-1098. https://doi.org/10.3892/ijo.2014.2295
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