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Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice

  • Authors:
    • Jinhuo Lai
    • Qian Cai
    • Merrill A. Biel
    • Chuan Wang
    • Xiaohua Hu
    • Shaoyuan Wang
    • Jizhen Lin
  • View Affiliations / Copyright

    Affiliations: Department of Oncology of Union Hospital, Institute of Immunotherapy, Fujian Medical University, Fuzhou, P.R. China, Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong, P.R. China, Ear, Nose and Throat Specialty Care of Minnesota, Minneapolis, MN, USA
    Copyright: © Lai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1481-1489
    |
    Published online on: February 21, 2014
       https://doi.org/10.3892/ijo.2014.2309
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Abstract

Id1 and NF-κB are highly expressed in oral squamous cell carcinoma (OSCC). Whether they have a synergistic role in the carcinogenesis of OSCC is unclear. The current study was designed to demonstrate the synergy of both Id1 and NF-κB in the underlying disease mechanisms of OSCC using in vitro and in vivo animal models. Id1 and NF-κB strengthened the expression of both CD133 and BMI-1 in OSCC cell cultures. CD133+ and BMI-1+ keratinocytes from OSCC tissues and cell cultures initiated the growth of xenograft tumors in SCID/Beige mice. Id1 and NF-κB regulate the expression of CD133 and BMI-1 in an additive or synergistic manner in OSCC, which is associated with the generation of naïve and self-renewable keratinocytes and initiate the growth of xenograft tumors in vivo.
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Copy and paste a formatted citation
Spandidos Publications style
Lai J, Cai Q, Biel MA, Wang C, Hu X, Wang S and Lin J: Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice. Int J Oncol 44: 1481-1489, 2014.
APA
Lai, J., Cai, Q., Biel, M.A., Wang, C., Hu, X., Wang, S., & Lin, J. (2014). Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice. International Journal of Oncology, 44, 1481-1489. https://doi.org/10.3892/ijo.2014.2309
MLA
Lai, J., Cai, Q., Biel, M. A., Wang, C., Hu, X., Wang, S., Lin, J."Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice". International Journal of Oncology 44.5 (2014): 1481-1489.
Chicago
Lai, J., Cai, Q., Biel, M. A., Wang, C., Hu, X., Wang, S., Lin, J."Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice". International Journal of Oncology 44, no. 5 (2014): 1481-1489. https://doi.org/10.3892/ijo.2014.2309
Copy and paste a formatted citation
x
Spandidos Publications style
Lai J, Cai Q, Biel MA, Wang C, Hu X, Wang S and Lin J: Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice. Int J Oncol 44: 1481-1489, 2014.
APA
Lai, J., Cai, Q., Biel, M.A., Wang, C., Hu, X., Wang, S., & Lin, J. (2014). Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice. International Journal of Oncology, 44, 1481-1489. https://doi.org/10.3892/ijo.2014.2309
MLA
Lai, J., Cai, Q., Biel, M. A., Wang, C., Hu, X., Wang, S., Lin, J."Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice". International Journal of Oncology 44.5 (2014): 1481-1489.
Chicago
Lai, J., Cai, Q., Biel, M. A., Wang, C., Hu, X., Wang, S., Lin, J."Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice". International Journal of Oncology 44, no. 5 (2014): 1481-1489. https://doi.org/10.3892/ijo.2014.2309
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