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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2014 Volume 44 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)

  • Authors:
    • Xin Sun
    • Zhi-Ming Wang
    • Yan Song
    • Xu-Hui Tai
    • Wen-Yue Ji
    • Hui Gu
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolarynology, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China, Department of Stomatology, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China, Department of Otorhinolarynology, Chinese PLA 463 Hospital, P.R. China, Department of Central Laboratory, Shengjing Hospital, China Medical University, Shenyang 110004, P.R. China
  • Pages: 1678-1684
    |
    Published online on: March 5, 2014
       https://doi.org/10.3892/ijo.2014.2321
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Abstract

Plasma miRNAs have been reported as biomarkers for various diseases. In this study, we investigated whether plasma concentrations of miR-126 may be useful as biomarkers for laryngeal squamous cell carcinoma (LSCC). We examined the function and mechanism of miR-126 in LSCC by using cell biology and molecular pathology techniques such as western blotting, quantitative PCR, IHC and IF. The expression of Camsap1 mRNA and protein is higher in cancer tissues compared to that in normal tissues. Both miR-126 and Camsap1 were related with the prognosis of LSCC patients. We found that miR-126 was able to inhibit LSCC partly by suppressing Camsap1 expression. In addition, Camsap1 expression induced microtubule formation and aggregation. This mechanism possibly explains why loss of miR-126 is frequently associated with tumor metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Wang Z, Song Y, Tai X, Ji W and Gu H: MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). Int J Oncol 44: 1678-1684, 2014.
APA
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., & Gu, H. (2014). MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). International Journal of Oncology, 44, 1678-1684. https://doi.org/10.3892/ijo.2014.2321
MLA
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., Gu, H."MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)". International Journal of Oncology 44.5 (2014): 1678-1684.
Chicago
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., Gu, H."MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)". International Journal of Oncology 44, no. 5 (2014): 1678-1684. https://doi.org/10.3892/ijo.2014.2321
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Wang Z, Song Y, Tai X, Ji W and Gu H: MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). Int J Oncol 44: 1678-1684, 2014.
APA
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., & Gu, H. (2014). MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). International Journal of Oncology, 44, 1678-1684. https://doi.org/10.3892/ijo.2014.2321
MLA
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., Gu, H."MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)". International Journal of Oncology 44.5 (2014): 1678-1684.
Chicago
Sun, X., Wang, Z., Song, Y., Tai, X., Ji, W., Gu, H."MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)". International Journal of Oncology 44, no. 5 (2014): 1678-1684. https://doi.org/10.3892/ijo.2014.2321
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