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Article

Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance

  • Authors:
    • Rishil J. Kathawala
    • Jun-Jiang Chen
    • Yun-Kai Zhang
    • Yi-Jun Wang
    • Atish Patel
    • De-Shen Wang
    • Tanaji T. Talele
    • Charles R. Ashby
    • Zhe-Sheng Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, USA
  • Pages: 1634-1642
    |
    Published online on: March 13, 2014
       https://doi.org/10.3892/ijo.2014.2341
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Abstract

In this in vitro study, we determined whether masitinib could reverse multidrug resistance (MDR) in cells overexpressing the ATP binding cassette subfamily G member 2 (ABCG2) transporter. Masitinib (1.25 and 2.5 µM) significantly decreases the resistance to mitoxantrone (MX), SN38 and doxorubicin in HEK293 and H460 cells overexpressing the ABCG2 transporter. In addition, masitinib (2.5 µM) significantly increased the intracellular accumulation of [3H]-MX, a substrate for ABCG2, by inhibiting the function of ABCG2 and significantly decreased the efflux of [3H]-MX. However, masitinib (2.5 µM) did not significantly alter the expression of the ABCG2 protein. In addition, a docking model suggested that masitinib binds within the transmembrane region of a homology-modeled human ABCG2 transporter. Overall, our in vitro findings suggest that masitinib reverses MDR to various anti-neoplastic drugs in HEK293 and H460 cells overexpressing ABCG2 by inhibiting their transport activity as opposed to altering their levels of expression.
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1. 

Wu CP, Calcagno AM and Ambudkar SV: Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr Mol Pharmacol. 1:93–105. 2008. View Article : Google Scholar

2. 

Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med. 53:615–627. 2002. View Article : Google Scholar : PubMed/NCBI

3. 

Quintieri L, Fantin M and Vizler C: Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs. Adv Exp Med Biol. 593:95–104. 2007. View Article : Google Scholar : PubMed/NCBI

4. 

Liu YY, Han TY, Giuliano AE and Cabot MC: Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J. 15:719–730. 2001. View Article : Google Scholar

5. 

Lowe SW, Ruley HE, Jacks T and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957–967. 1993. View Article : Google Scholar : PubMed/NCBI

6. 

Synold TW, Dussault I and Forman BM: The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med. 7:584–590. 2001. View Article : Google Scholar

7. 

Deeley RG, Westlake C and Cole SP: Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev. 86:849–899. 2006. View Article : Google Scholar : PubMed/NCBI

8. 

Bradbury PA and Middleton MR: DNA repair pathways in drug resistance in melanoma. Anticancer Drugs. 15:421–426. 2004. View Article : Google Scholar

9. 

Ambudkar SV, Kim IW, Xia D and Sauna ZE: The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding. FEBS Lett. 580:1049–1055. 2006. View Article : Google Scholar

10. 

Liu FS: Mechanisms of chemotherapeutic drug resistance in cancer therapy - a quick review. Taiwan J Obstet Gynecol. 48:239–244. 2009. View Article : Google Scholar : PubMed/NCBI

11. 

Gillet JP, Efferth T and Remacle J: Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim Biophys Acta. 1775:237–262. 2007.PubMed/NCBI

12. 

Linton KJ and Higgins CF: Structure and function of ABC transporters: the ATP switch provides flexible control. Pflugers Arch. 453:555–567. 2007. View Article : Google Scholar : PubMed/NCBI

13. 

Sodani K, Patel A, Kathawala RJ and Chen ZS: Multidrug resistance associated proteins in multidrug resistance. Chin J Cancer. 31:58–72. 2012. View Article : Google Scholar : PubMed/NCBI

14. 

Tiwari AK, Sodani K, Dai CL, Ashby CR Jr and Chen ZS: Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Curr Pharm Biotechnol. 12:570–594. 2011. View Article : Google Scholar : PubMed/NCBI

15. 

Mao Q and Unadkat JD: Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J. 7:E118–E133. 2005. View Article : Google Scholar : PubMed/NCBI

16. 

Suzuki M, Suzuki H, Sugimoto Y and Sugiyama Y: ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 278:22644–22649. 2003. View Article : Google Scholar : PubMed/NCBI

17. 

Rocchi E, Khodjakov A, Volk EL, et al: The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun. 271:42–46. 2000. View Article : Google Scholar : PubMed/NCBI

18. 

Maliepaard M, Scheffer GL, Faneyte IF, et al: Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61:3458–3464. 2001.PubMed/NCBI

19. 

Cooray HC, Blackmore CG, Maskell L and Barrand MA: Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport. 13:2059–2063. 2002. View Article : Google Scholar : PubMed/NCBI

20. 

Doyle LA, Yang W, Abruzzo LV, et al: A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA. 95:15665–15670. 1998. View Article : Google Scholar : PubMed/NCBI

21. 

Schinkel AH and Jonker JW: Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev. 55:3–29. 2003. View Article : Google Scholar : PubMed/NCBI

22. 

Dean M and Allikmets R: Complete characterization of the human ABC gene family. J Bioenerg Biomembr. 33:475–479. 2001. View Article : Google Scholar : PubMed/NCBI

23. 

Miyake K, Mickley L, Litman T, et al: Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res. 59:8–13. 1999.

24. 

Chen ZS, Robey RW, Belinsky MG, et al: Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 63:4048–4054. 2003.PubMed/NCBI

25. 

Honjo Y, Hrycyna CA, Yan QW, et al: Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. Cancer Res. 61:6635–6639. 2001.PubMed/NCBI

26. 

Dai CL, Liang YJ, Wang YS, et al: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 279:74–83. 2009. View Article : Google Scholar : PubMed/NCBI

27. 

Pozza A, Perez-Victoria JM, Sardo A, Ahmed-Belkacem A and Di Pietro A: Purification of breast cancer resistance protein ABCG2 and role of arginine-482. Cell Mol Life Sci. 63:1912–1922. 2006. View Article : Google Scholar : PubMed/NCBI

28. 

Ejendal KF and Hrycyna CA: Multidrug resistance and cancer: the role of the human ABC transporter ABCG2. Curr Protein Pept Sci. 3:503–511. 2002. View Article : Google Scholar : PubMed/NCBI

29. 

Padmanabhan R, Chen KG, Gillet JP, et al: Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. Stem Cells. 30:2175–2187. 2012. View Article : Google Scholar : PubMed/NCBI

30. 

Evseenko DA, Paxton JW and Keelan JA: Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos. 35:595–601. 2007. View Article : Google Scholar : PubMed/NCBI

31. 

Chen ZS, Aoki S, Komatsu M, et al: Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function. Int J Cancer. 93:107–113. 2001. View Article : Google Scholar : PubMed/NCBI

32. 

Dai CL, Tiwari AK, Wu CP, et al: Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res. 68:7905–7914. 2008. View Article : Google Scholar

33. 

Kathawala RJ, Wang YJ, Ashby CR Jr and Chen ZS: Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs. Chin J Cancer. Oct 9–2013.(Epub ahead of print).

34. 

Deng W, Dai CL, Chen JJ, et al: Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10). Oncol Rep. 29:2479–2485. 2013.PubMed/NCBI

35. 

Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM: Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 5:219–234. 2006. View Article : Google Scholar

36. 

Yang D, Kathawala RJ, Chufan EE, et al: Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Future Oncol. Dec 3–2013.(Epub ahead of print).

37. 

Shen T, Kuang YH, Ashby CR, et al: Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). PLoS One. 4:e75202009. View Article : Google Scholar : PubMed/NCBI

38. 

Tiwari AK, Sodani K, Wang SR, et al: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 78:153–161. 2009. View Article : Google Scholar : PubMed/NCBI

39. 

Shi Z, Peng XX, Kim IW, et al: Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance. Cancer Res. 67:11012–11020. 2007. View Article : Google Scholar : PubMed/NCBI

40. 

Vermersch P, Benrabah R, Schmidt N, et al: Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol. 12:362012. View Article : Google Scholar : PubMed/NCBI

41. 

Rommer PS and Stuve O: Management of secondary progressive multiple sclerosis: prophylactic treatment-past, present, and future aspects. Curr Treat Options Neurol. 15:241–258. 2013. View Article : Google Scholar : PubMed/NCBI

42. 

Humbert M, de Blay F, Garcia G, et al: Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics. Allergy. 64:1194–1201. 2009. View Article : Google Scholar : PubMed/NCBI

43. 

Lee-Fowler TM, Guntur V, Dodam J, Cohn LA, DeClue AE and Reinero CR: The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma. Int Arch Allergy Immunol. 158:369–374. 2012. View Article : Google Scholar : PubMed/NCBI

44. 

Tebib J, Mariette X, Bourgeois P, et al: Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res Ther. 11:R952009. View Article : Google Scholar : PubMed/NCBI

45. 

Walker UA: More about masitinib. Arthritis Res Ther. 11:1202009. View Article : Google Scholar

46. 

Georgin-Lavialle S, Lhermitte L, Suarez F, et al: Mast cell leukemia: identification of a new c-Kit mutation, dup(501–502) and response to masitinib, a c-Kit tyrosine kinase inhibitor. Eur J Haematol. 89:47–52. 2012.PubMed/NCBI

47. 

Paul C, Sans B, Suarez F, et al: Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study. Am J Hematol. 85:921–925. 2010. View Article : Google Scholar : PubMed/NCBI

48. 

Le Cesne A, Blay JY, Bui BN, et al: Phase II study of oral masitinib mesilate in imatinib-naive patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST). Eur J Cancer. 46:1344–1351. 2010.PubMed/NCBI

49. 

Mitry E, Hammel P, Deplanque G, et al: Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer. Cancer Chemother Pharmacol. 66:395–403. 2010. View Article : Google Scholar : PubMed/NCBI

50. 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

51. 

Kruh GD, Guo Y, Hopper-Borge E, Belinsky MG and Chen ZS: ABCC10, ABCC11, and ABCC12. Pflugers Arch. 453:675–684. 2007. View Article : Google Scholar : PubMed/NCBI

52. 

Robey RW, Honjo Y, Morisaki K, et al: Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. Br J Cancer. 89:1971–1978. 2003. View Article : Google Scholar : PubMed/NCBI

53. 

Carmichael J, DeGraff WG, Gazdar AF, Minna JD and Mitchell JB: Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47:936–942. 1987.PubMed/NCBI

54. 

Hazai E and Bikadi Z: Homology modeling of breast cancer resistance protein (ABCG2). J Struct Biol. 162:63–74. 2008. View Article : Google Scholar : PubMed/NCBI

55. 

Alqawi O, Bates S and Georges E: Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Biochem J. 382:711–716. 2004. View Article : Google Scholar : PubMed/NCBI

56. 

Sun YL, Kathawala RJ, Singh S, et al: Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Anticancer Drugs. 23:865–873. 2012. View Article : Google Scholar : PubMed/NCBI

57. 

Litman T, Brangi M, Hudson E, et al: The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci. 113:2011–2021. 2000.PubMed/NCBI

58. 

Schellens JH, Maliepaard M, Scheper RJ, et al: Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications. Ann NY Acad Sci. 922:188–194. 2000. View Article : Google Scholar : PubMed/NCBI

59. 

Jonker JW, Smit JW, Brinkhuis RF, et al: Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst. 92:1651–1656. 2000. View Article : Google Scholar : PubMed/NCBI

60. 

Nakamura Y, Oka M and Soda H: Gefitinib (‘Iressa’, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance. Cancer Res. 65:1541–1546. 2005.

61. 

Shukla S, Robey RW, Bates SE and Ambudkar SV: Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 37:359–365. 2009. View Article : Google Scholar

62. 

Mi YJ, Liang YJ, Huang HB, et al: Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 70:7981–7991. 2010. View Article : Google Scholar : PubMed/NCBI

63. 

Nicolle E, Boumendjel A, Macalou S, et al: QSAR analysis and molecular modeling of ABCG2-specific inhibitors. Adv Drug Deliv Rev. 61:34–46. 2009. View Article : Google Scholar : PubMed/NCBI

64. 

An Y and Ongkeko WM: ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol. 5:1529–1542. 2009. View Article : Google Scholar : PubMed/NCBI

65. 

Chen YJ, Huang WC, Wei YL, et al: Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. PLoS One. 6:e214282011. View Article : Google Scholar : PubMed/NCBI

66. 

Natarajan K, Xie Y, Baer MR and Ross DD: Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol. 83:1084–1103. 2012. View Article : Google Scholar : PubMed/NCBI

67. 

Kerr ID, Haider AJ and Gelissen IC: The ABCG family of membrane-associated transporters: you don’t have to be big to be mighty. Br J Pharmacol. 164:1767–1779. 2011.

68. 

Robey RW, Medina-Perez WY, Nishiyama K, et al: Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells. Clin Cancer Res. 7:145–152. 2001.PubMed/NCBI

69. 

Robey RW, Ierano C, Zhan Z and Bates SE: The challenge of exploiting ABCG2 in the clinic. Curr Pharm Biotechnol. 12:595–608. 2011. View Article : Google Scholar : PubMed/NCBI

70. 

Woodward OM, Kottgen A and Kottgen M: ABCG transporters and disease. FEBS J. 278:3215–3225. 2011. View Article : Google Scholar : PubMed/NCBI

71. 

Xu J, Peng H and Zhang JT: Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy. Curr Med Chem. 14:689–701. 2007. View Article : Google Scholar : PubMed/NCBI

72. 

Hang D, Dong HC, Ning T, Dong B, Hou DL and Xu WG: Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma. Dis Esophagus. 25:638–644. 2012. View Article : Google Scholar : PubMed/NCBI

73. 

Li J, Li ZN, Du YJ, Li XQ, Bao QL and Chen P: Expression of MRP1, BCRP, LRP, and ERCC1 in advanced non-small-cell lung cancer: correlation with response to chemotherapy and survival. Clin Lung Cancer. 10:414–421. 2009. View Article : Google Scholar

74. 

Tsunoda S, Okumura T, Ito T, et al: ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology. 71:251–258. 2006. View Article : Google Scholar : PubMed/NCBI

75. 

Bunting KD: ABC transporters as phenotypic markers and functional regulators of stem cells. Stem Cells. 20:11–20. 2002. View Article : Google Scholar : PubMed/NCBI

76. 

Kim M, Turnquist H, Jackson J, et al: The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res. 8:22–28. 2002.PubMed/NCBI

77. 

Kusuhara H and Sugiyama Y: ATP-binding cassette, subfamily G (ABCG family). Pflugers Arch. 453:735–744. 2007. View Article : Google Scholar : PubMed/NCBI

78. 

Ding XW, Wu JH and Jiang CP: ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci. 86:631–637. 2010. View Article : Google Scholar : PubMed/NCBI

79. 

Sung JM, Cho HJ, Yi H, et al: Characterization of a stem cell population in lung cancer A549 cells. Biochem Biophys Res Commun. 371:163–167. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kathawala RJ, Chen J, Zhang Y, Wang Y, Patel A, Wang D, Talele TT, Ashby CR and Chen Z: Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int J Oncol 44: 1634-1642, 2014.
APA
Kathawala, R.J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D. ... Chen, Z. (2014). Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. International Journal of Oncology, 44, 1634-1642. https://doi.org/10.3892/ijo.2014.2341
MLA
Kathawala, R. J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D., Talele, T. T., Ashby, C. R., Chen, Z."Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance". International Journal of Oncology 44.5 (2014): 1634-1642.
Chicago
Kathawala, R. J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D., Talele, T. T., Ashby, C. R., Chen, Z."Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance". International Journal of Oncology 44, no. 5 (2014): 1634-1642. https://doi.org/10.3892/ijo.2014.2341
Copy and paste a formatted citation
x
Spandidos Publications style
Kathawala RJ, Chen J, Zhang Y, Wang Y, Patel A, Wang D, Talele TT, Ashby CR and Chen Z: Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int J Oncol 44: 1634-1642, 2014.
APA
Kathawala, R.J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D. ... Chen, Z. (2014). Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. International Journal of Oncology, 44, 1634-1642. https://doi.org/10.3892/ijo.2014.2341
MLA
Kathawala, R. J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D., Talele, T. T., Ashby, C. R., Chen, Z."Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance". International Journal of Oncology 44.5 (2014): 1634-1642.
Chicago
Kathawala, R. J., Chen, J., Zhang, Y., Wang, Y., Patel, A., Wang, D., Talele, T. T., Ashby, C. R., Chen, Z."Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance". International Journal of Oncology 44, no. 5 (2014): 1634-1642. https://doi.org/10.3892/ijo.2014.2341
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