Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma

  • Authors:
    • Lee Fah Yap
    • Munirah Ahmad
    • Muhammad Mamduh Ahmad Zabidi
    • Tai Lin Chu
    • San Jiun Chai
    • Hui Min Lee
    • Paul Vey Hong Lim
    • Wenbin Wei
    • Christopher Dawson
    • Soo-Hwang Teo
    • Alan Soo Beng Khoo
  • View Affiliations

  • Published online on: March 13, 2014     https://doi.org/10.3892/ijo.2014.2342
  • Pages: 1774-1780
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Abstract

The molecular events that drive the progression of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) are still to be elucidated. Here, we report for the first time the pathogenic significance of an NPC-associated gene, wingless-type MMTV integration site family, member 5A (WNT5A) and the contribution of EBV to its expression. WNT5A is a representative Wnt protein that activates non-canonical Wnt signalling. With regard to its role in carcinogenesis, there is conflicting evidence as to whether WNT5A has a tumour-promoting or tumour-suppressive role. We show that WNT5A is upregulated in primary NPC tissue samples. We also demonstrate that WNT5A expression was dramatically increased in NPC cell lines expressing the EBV-encoded LMP2A gene, suggesting that this EBV-encoded latent gene is responsible for upregulating WNT5A in NPC. In addition, in vitro WNT5A overexpression promotes the proliferation, migration and invasion of NPC cells. Our results not only reveal pro-tumorigenic effects of WNT5A in NPC but also suggest that WNT5A could be an important therapeutic target in patients with EBV-associated disease.
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May-2014
Volume 44 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yap LF, Ahmad M, Zabidi MM, Chu TL, Chai SJ, Lee HM, Lim PV, Wei W, Dawson C, Teo S, Teo S, et al: Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma. Int J Oncol 44: 1774-1780, 2014
APA
Yap, L.F., Ahmad, M., Zabidi, M.M., Chu, T.L., Chai, S.J., Lee, H.M. ... Khoo, A.S. (2014). Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma. International Journal of Oncology, 44, 1774-1780. https://doi.org/10.3892/ijo.2014.2342
MLA
Yap, L. F., Ahmad, M., Zabidi, M. M., Chu, T. L., Chai, S. J., Lee, H. M., Lim, P. V., Wei, W., Dawson, C., Teo, S., Khoo, A. S."Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma". International Journal of Oncology 44.5 (2014): 1774-1780.
Chicago
Yap, L. F., Ahmad, M., Zabidi, M. M., Chu, T. L., Chai, S. J., Lee, H. M., Lim, P. V., Wei, W., Dawson, C., Teo, S., Khoo, A. S."Oncogenic effects of WNT5A in Epstein-Barr virus‑associated nasopharyngeal carcinoma". International Journal of Oncology 44, no. 5 (2014): 1774-1780. https://doi.org/10.3892/ijo.2014.2342