miR‑181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1

  • Authors:
    • Fei Lu
    • Jingru Zhang
    • Min Ji
    • Peng Li
    • Yahui Du
    • Hongchun Wang
    • Shaolei Zang
    • Daoxin Ma
    • Xiulian Sun
    • Chunyan Ji
  • View Affiliations

  • Published online on: April 16, 2014     https://doi.org/10.3892/ijo.2014.2390
  • Pages: 383-392
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Abstract

Multidrug resistance (MDR) remains the major cause of disease relapse and poor prognosis in adults with acute myeloid leukemia (AML). Emerging evidence shows that drug resistance not only exists against conventional chemotherapeutic drugs, but also limits the efficacy of new biological agents. Therefore, it is important to elucidate the mechanisms through which AML patients develop drug resistance. MicroRNAs have been shown to play an important role in regulating the chemotherapy resistance in AML. A detailed understanding of the mechanisms of microRNA that are clinically relevant in AML may enhance our ability to predict and overcome drug resistance. Here, we demonstrated, for the first time, that miR‑181b was decreased significantly in human multidrug-resistant leukemia cells and relapsed/refractory AML patient samples. Overexpression of miR‑181b increased the sensitivity of leukemia cells to cytotoxic chemotherapeutic agents and promoted drug-induced apoptosis. Moreover, miR‑181b inhibited HMGB1 and Mcl-1 expression by direct binding to their 3'-untranslated regions. In addition, HMGB1 was expressed at high levels in relapsed/refractory AML patients and suppression of HMGB1 via RNA interference sensitized multidrug-resistant leukemia cells to chemotherapy and induced apoptosis. In conclusion, these results provide a strong rationale for the development of miR‑181b-based therapeutic strategies for the enhancement of efficacy in AML treatment.
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July-2014
Volume 45 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lu F, Zhang J, Ji M, Li P, Du Y, Wang H, Zang S, Ma D, Sun X, Ji C, Ji C, et al: miR‑181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1. Int J Oncol 45: 383-392, 2014
APA
Lu, F., Zhang, J., Ji, M., Li, P., Du, Y., Wang, H. ... Ji, C. (2014). miR‑181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1. International Journal of Oncology, 45, 383-392. https://doi.org/10.3892/ijo.2014.2390
MLA
Lu, F., Zhang, J., Ji, M., Li, P., Du, Y., Wang, H., Zang, S., Ma, D., Sun, X., Ji, C."miR‑181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1". International Journal of Oncology 45.1 (2014): 383-392.
Chicago
Lu, F., Zhang, J., Ji, M., Li, P., Du, Y., Wang, H., Zang, S., Ma, D., Sun, X., Ji, C."miR‑181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1". International Journal of Oncology 45, no. 1 (2014): 383-392. https://doi.org/10.3892/ijo.2014.2390