|
1.
|
Young JC, Agashe VR, Siegers K and Hartl
FU: Pathways of chaperone-mediated protein folding in the cytosol.
Nat Rev Mol Cell Biol. 5:781–791. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
2.
|
Lindquist S and Craig EA: The heat-shock
proteins. Annu Rev Genet. 22:631–77. 1998. View Article : Google Scholar
|
|
3.
|
Lebret T, Watson RW and Fitzpatrick JM:
Heat shock proteins: their role in urological tumours. J Urolog.
169:338–346. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Khalil AA, Kabapy NF, Deraz SF and Smith
C: Heat shock proteins in oncology: diagnostic biomarkers or
therapeutic targets? Biochim Biophys Acta. 1816:89–104.
2011.PubMed/NCBI
|
|
5.
|
Jego G, Hazoumé A, Seigneuric R and
Garrido C: Targeting heat shock proteins in cancer. Cancer Lett.
332:275–285. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
6.
|
Xia Y, Rocchi P, Iovanna JL and Peng L:
Targeting heat shock response pathways to treat pancreatic cancer.
Drug Discov Today. 17:35–43. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Garrido C, Brunet M, Didelot C, Zermati Y,
Schmitt E and Kroemer G: Heat shock proteins 27 and 70:
anti-apoptotic proteins with tumorigenic properties. Cell Cycle.
5:2592–2601. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Joly AL, Wettstein G, Mignot G,
Ghiringhelli F and Garrido C: Dual role of heat-shock proteins as
regulator of apoptosis and innate immunity. J Innate Immun.
2:238–247. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Wei MC, Zong WX, Cheng EH, Lindsten T,
Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB and
Korsmeyer SJ: Proapoptotic BAX and BAK: a requisite gateway to
mitochondrial dysfunction and death. Science. 292:727–30. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
10.
|
Zong WX, Lindsten T, Ross AJ, MacGregor GR
and Thompson CB: BH3-only proteins that bind pro-survival Bcl-2
family members fail to induce apoptosis in the absence of Bax and
Bak. Genes Dev. 15:1481–1486. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
11.
|
Garrido C, Galluzzi L, Brunet M, Puig PE,
Didelot C and Kroemer G: Mechanisms of cytochrome c release from
mitochondria. Cell Death Differ. 13:1423–1433. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Li P, Nijhawan D, Budihardjo I,
Srinivasula SM, Ahmad M, Alnemri ES and Wang X: Cytochrome c and
dATP-dependent formation of Apaf-1/caspase-9 complex initiates an
apoptotic protease cascade. Cell. 91:479–489. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
13.
|
Joza N, Susin SA, Daugas E, Stanford WL,
Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF,
Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW,
Zuniga-Pflucker JC, Kroemer G and Penninger JM: Essential role of
the mitochondrial apoptosis-inducing factor in programmed cell
death. Nature. 410:549–554. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Du C, Fang M, Li Y, Li L and Wang X: Smac,
a mitochondrial protein that promotes cytochrome c-dependent
caspase activation by eliminating IAP inhibition. Cell. 102:33–42.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Luo X, Budihardjo I, Zou H, Slaughter C
and Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c
release from mitochondria in response to activation of cell surface
death receptors. Cell. 94:481–490. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Shamovsky I and Nudler E: New insights
into the mechanism of heat shock response activation. Cell Mol Life
Sci. 65:855–861. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Akerfelt M, Morimoto RI and Sistonen L:
Heat shock factors: integrators of cell stress, developmentand
lifespan. Nat Rev Mol Cell Biol. 11:545–555. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Green M, Schuetz TJ, Sullivan EK and
Kingston RE: A heat-shock responsive domain of human HSF1 that
regulates transcription activation domain function. Mol Cell Biol.
15:3354–3362. 1995.PubMed/NCBI
|
|
19.
|
Sistonen L, Sarge KD and Morimoto RI:
Human heat shock factors 1 and 2 are differentially activated and
can synergistically induce hsp70 gene transcription. Mol Cell Biol.
14:2087–2099. 1994.PubMed/NCBI
|
|
20.
|
Nakai A, Tanabe M, Kawazoe Y, Inazawa J,
Morimoto RI and Nagata K: HSF4, a new member of the human heat
shock factor family which lacks properties of a transcriptional
activator. Mol Cell Biol. 17:469–481. 1997.PubMed/NCBI
|
|
21.
|
Akerfelt M, Trouillet D, Mezger V and
Sistonen L: Heat shock factors at a cross road between stress and
development. Ann NY Acad Sci. 1113:15–27. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
Abane R and Mezger V: Roles of heat shock
factors in gameto-genesis and development. FEBS J. 277:4150–4172.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Whitesell L and Lindquist S: Inhibiting
the transcription factor HSF1 as an anticancer strategy. Expert
Opin Ther Targets. 13:469–478. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
24.
|
Westerheide SD, Kawahara TL, Orton K and
Morimoto RI: Triptolide, an inhibitor of the human heat shock
response that enhances stress-induced cell death. J Biol Chem.
281:9616–9622. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
25.
|
Sugiyama Y, Suzuki A, Kishikawa M, Akutsu
R, Hirose T and Waye MM: Muscle develops a specific form of small
heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during
myogenic differentiation. J Biol Chem. 275:1095–1104. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
26.
|
Kostenko S and Moens U: Heat shock protein
27 phosphorylation: kinases, phosphatases, functions and pathology.
Cell Mol Life Sci. 66:3289–3307. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Shin KD, Lee MY, Shin DS, Lee S, Son KH,
Koh S, Paik YK, Kwon BM and Han DC: Blocking tumor cell migration
and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic
molecule that inhibits Hsp27 phosphorylation. J Biol Chem.
280:41439–41448. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Gobbo J, Gaucher-Di-Stasio C, Weidmann S,
Guzzo J and Garrido C: Quantification of HSP27 and HSP70 molecular
chaperone activities. Methods Mol Biol. 787:137–143. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
29.
|
Bruey JM, Paul C, Fromentin A, Hilpert S,
Arrigo AP, Solary E and Garrido C: Differential regulation of HSP27
oligomerization in tumor cells grown in vitro and in vivo.
Oncogene. 19:4855–4863. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Shashidharamurthy R, Koteiche HA, Dong J
and McHaourab HS: Mechanism of chaperone function in small heat
shock proteins: Dissociation of the HSP27 oligomer is required for
recognition and binding of destabilized T4 lysozyme. J Biol Chem.
280:5281–5289. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Charette SJ, Lavoie JN, Lambert H and
Landry J: Inhibition of Daxx-mediated apoptosis by heat shock
protein 27. Mol Cell Biol. 20:7602–7612. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
32.
|
Akbar MT, Lundberg AM, Liu K, Vidyadaran
S, Wells KE, Dolatshad H, Wynn S, Wells DJ, Latchman DS and de
Belleroche J: The neuroprotective effects of heat shock protein 27
overexpression in transgenic animals against kainate-induced
seizures and hippocampal cell death. J Biol Chem. 278:19956–19965.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Straume O, Shimamura T, Lampa MJ,
Carretero J, Øyan AM, Jia D, Borgman CL and Soucheray M:
Suppression of heat shock protein 27 induces long-term dormancy in
human breast cancer. Proc Natl Acad Sci USA. 109:8699–8704. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
34.
|
Bauer K, Nitsche U, Slotta-Huspenina J,
Drecoll E, Von Weyhern CH, Rosenberg R, Höfler H and Langer R: High
HSP27 and HSP70 expression levels are independent adverse
prognostic factors in primary resected colon cancer. Cell Oncol
(Dordr). 35:197–205. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Chen SF, Nieh S, Jao SW, Liu CL, Wu CH,
Chang YC, Yang CY and Lin YS: Quercetin suppresses drug-resistant
spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer
cells. PLoS One. 7:e492752012. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Ciocca DR, Arrigo AP and Calderwood SK:
Heat shock proteins and heat shock factor 1 in carcinogenesis and
tumor development: an update. Arch Toxicol. 87:19–48. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Pavan S, Musiani D, Torchiaro E, Migliardi
G, Gai M, Di Cunto F, Erriquez J, Olivero M and Di Renzo MF: HSP27
is required for invasion and metastasis triggered by hepatocyte
growth factor. Int J Cancer. 134:1289–1299. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
38.
|
Acunzo J, Katsogiannou M and Rocchi P:
Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and
HSP22 (HspB8) as regulators of cell death. Int J Biochem Cell Biol.
44:1622–1631. 2012.
|
|
39.
|
Schmitt E, Gehrmann M, Brunet M, Multhoff
G and Garrido C: Intracellular and extracellular functions of heat
shock proteins: repercussions in cancer therapy. J Leukoc Biol.
81:15–27. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
40.
|
Voss OH, Batra S, Kolattukudy SJ,
Gonzalez-Mejia ME, Smith JB and Doseff AI: Binding of caspase-3
prodomain to heat shock protein 27 regulates monocyte apoptosis by
inhibiting caspase-3 proteolytic activation. J Biol Chem.
282:25088–25099. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
41.
|
Rocchi P, Jugpal P, So A, Sinneman S,
Ettinger S, Fazli L, Nelson C and Gleave M: Small interference RNA
targeting heat-shock protein 27 inhibits the growth of prostatic
cell lines and induces apoptosis via caspase-3 activation in vitro.
BJU Int. 98:1082–1089. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
42.
|
Paul C, Manero F, Gonin S, Kretz-Remy C,
Virot S and Arrigo AP: Hsp27 as a negative regulator of cytochrome
c release. Mol Cell Biol. 22:816–834. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
43.
|
Chauhan D, Li G, Hideshima T, Podar K,
Mitsiades C, Mitsiades N, Catley L, Tai YT, Hayashi T, Shringarpure
R, Burger R, Munshi N, Ohtake Y, Saxena S and Anderson KC: Hsp27
inhibits release of mitochondrial protein Smac in multiple myeloma
cells and confers dexamethasone resistance. Blood. 102:3379–3386.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
44.
|
Havasi A, Li Z, Wang Z, Martin JL, Botla V
and Ruchalski K: Hsp27 inhibits Bax activation and apoptosis via a
phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem.
283:12305–12313. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
45.
|
Arrigo AP, Virot S, Chaufour S, Firdaus W,
Kretz-Remy C and Diaz-Latoud C: Hsp27 consolidates intracellular
redox homeostasis by upholding glutathione in its reduced form and
by decreasing iron intracellular levels. Antioxid Redox Signal.
7:414–422. 2005. View Article : Google Scholar
|
|
46.
|
Rogalla T, Ehrnsperger M, Preville X,
Kotlyarov A, Lutsch G, Ducasse C, Paul C, Wieske M, Arrigo AP,
Buchner J and Gaestel M: Regulation of Hsp27 oligomerization,
chaperone function, and protective activity against oxidative
stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem.
274:18947–18956. 1999. View Article : Google Scholar
|
|
47.
|
Sanchez-Niño MD, Sanz AB, Sanchez-Lopez E,
Ruiz-Ortega M, Benito-Martin A, Saleem MA, Mathieson PW, Mezzano S,
Egido J and Ortiz A: HSP27/HSPB1 as an adaptive podocyte
antiapoptotic protein activated by highglucose and angiotensin II.
Lab Invest. 92:32–45. 2012.
|
|
48.
|
Solary E, Droin N, Bettaieb A, Corcos L,
Dimanche-Boitrel MT and Garrido C: Positive and negative regulation
of apoptotic pathways by cytotoxic agents in hematological
malignancies. Leukemia. 14:1833–1849. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
49.
|
Kamada M, So A, Muramaki M, Rocchi P,
Beraldi E and Gleave M: Hsp27 knockdown using nucleotide-based
therapies inhibit tumor growth and enhance chemotherapy in human
bladder cancer cells. Mol Cancer Ther. 6:299–308. 2007. View Article : Google Scholar
|
|
50.
|
Heinrich JC, Tuukkanen A, Schroeder M,
Fahrig T and Fahrig R: RP101 (brivudine) binds to heat shock
protein HSP27 (HSPB1) and enhances survival in animals and
pancreatic cancer patients. J Cancer Res Clin Oncol. 137:1349–1361.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
51.
|
Seigneuric R, Gobbo J, Colas P and Garrido
C: Targeting cancer with peptide aptamers. Oncotarget. 2:557–561.
2011.PubMed/NCBI
|
|
52.
|
Gibert B, Hadchity E, Czekalla A, Aloy MT,
Colas P, Rodriguez-Lafrasse C, Arrigo AP and Diaz-Latoud C:
Inhibition of heat shock protein 27 (HspB1) tumorigenic functions
by peptide aptamers. Oncogene. 30:3672–81. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
53.
|
Kampinga HH, Hageman J, Vos MJ, Kubota H,
Tanguay RM, Bruford EA, Cheetham ME, Chen B and Hightower LE:
Hightower, Guidelines for the nomenclature of the human heat shock
proteins. Cell Stress Chaperones. 14:105–111. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
54.
|
Jäättelä M: Heat shock proteins as
cellular lifeguards. Ann Med. 31:261–271. 1999.
|
|
55.
|
Beckmann RP, Mizzen LE and Welch WJ:
Interaction of Hsp 70 with newly synthesized proteins: Implications
for protein folding and assembly. Science. 248:850–854. 1990.
View Article : Google Scholar : PubMed/NCBI
|
|
56.
|
Murakami H, Pain D and Blobel G: 70-kD
heat shock-related protein is one of at least two distinct
cytosolic factors stimulating protein import into mitochondria. J
Cell Biol. 107:2051–2057. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
57.
|
Shi Y and Thomas JO: The transport of
proteins into the nucleus requires the 70-kilodalton heat shock
protein or its cytosolic cognate. Mol Cell Biol. 12:2186–2192.
1992.PubMed/NCBI
|
|
58.
|
Nollen EA, Brunsting JF, Roelofsen H,
Weber LA and Kampinga HH: In vivo chaperone activity of heat shock
protein 70 and thermotolerance. Mol Cell Biol. 19:2069–2079.
1999.PubMed/NCBI
|
|
59.
|
Vogel M, Bukau B and Mayer MP: Allosteric
regulation of Hsp70 chaperones by a proline switch. Mol Cell.
21:359–367. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
60.
|
Goloudina AR, Demidov ON and Garrido C:
Inhibition of HSP70: a challenging anti-cancer strategy. Cancer
Lett. 325:117–124. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
61.
|
Bukau B, Weissman J and Horwich A:
Molecular chaperones and protein quality control. Cell.
125:443–451. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
62.
|
Schmitt E, Parcellier A, Gurbuxani S,
Cande C, Hammann A, Morales MC, Hunt CR, Dix DJ, Kroemer RT,
Giordanetto F, Jäättelä M, Penninger JM, Pance A, Kroemer G and
Garrido C: Chemosensitization by a non-apoptogenic heat-shock
protein 70-binding apoptosis-inducing factor mutant. Cancer Res.
63:8233–8240. 2003.PubMed/NCBI
|
|
63.
|
Dix DJ, Allen JW, Collins BW, Mori C,
Nakamura N, Poorman-Allen P, Goulding EH and Eddy EM: Targeted gene
disruption of Hsp70-2 results in failed meiosis, germ cell
apoptosis, and male infertility. Proc Natl Acad Sci USA.
93:3264–3268. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
64.
|
Johnson TR, Stone K and Nikrad M: The
proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and
caspase 9-negative or Bcl-xL overexpressing cells. Oncogene.
22:4953–4963. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
65.
|
Hui-qing X, Jian-da Z, Xin-min N,
Yan-zhong Z, Cheng-qun L, Quan-yong H, Yi X, Pokharel PB, Shao-hua
W and Dan X: HSP70 inhibits burn serum-induced apoptosis of
cardiomyocytes via mitochondrial and membrane death receptor
pathways. J Burn Care Res. 29:512–518. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
66.
|
Park HS, Cho SG, Kim CK, Hwang HS, Noh KT,
Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko
YG, Kim S and Choi EJ: Heat shock protein hsp72 is a negative
regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol.
22:7721–7730. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
67.
|
Park HS, Lee JS, Huh SH, Seo JS and Choi
EJ: Hsp72 functions as a natural inhibitory protein of c-Jun
N-terminal kinase. EMBO J. 20:446–456. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
68.
|
Lee JS, Lee JJ and Seo JS: HSP70
deficiency results in activation of c-Jun N-terminal kinase,
extracellular signal-regulated kinase, and caspase-3 in
hyperosmolarity-induced apoptosis. J Biol Chem. 280:6634–6641.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
69.
|
Gao T and Newton AC: The turn motif is a
phosphorylation switch that regulates the binding of Hsp70 to
protein kinase C. J Biol Chem. 277:31585–31592. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
70.
|
Zylicz M, King FW and Wawrzynow A: Hsp70
interactions with the p53 tumour suppressor protein. EMBO J.
20:4634–4638. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
71.
|
Yang X, Wang J, Zhou Y, Wang Y, Wang S and
Zhang W: Hsp70 promotes chemoresistance by blocking Bax
mitochondrial translocation in ovariancancer cells. Cancer Lett.
321:137–143. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
72.
|
Stankiewicz AR, Lachapelle G, Foo CP,
Radicioni SM and Mosser DD: Hsp70 inhibits heat-induced apoptosis
upstream of mitochondria by preventing Bax translocation. J Biol
Chem. 280:38729–38739. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
73.
|
Li CY, Lee JS, Ko YG, Kim JI and Seo JS:
Heat shock protein 70 inhibits apoptosis down-stream of cytochrome
c release and upstream of caspase-3 activation. J Biol Chem.
275:25665–25671. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
74.
|
Beere HM, Wolf BB, Cain K, Mosser DD,
Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM and Green DR:
Heat-shock protein 70 inhibits apoptosis by preventing recruitment
of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2:469–475.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
75.
|
Creagh EM, Carmody RJ and Cotter TG: Heat
shock protein 70 inhibits caspase-dependent and-independent
apoptosis in Jurkat T cells. Exp Cell Res. 257:58–66. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
76.
|
Ravagnan L, Gurbuxani S, Susin SA, Maisse
C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger JM, Garrido C
and Kroemer G: Heat-shock protein 70 antagonizes apoptosis-inducing
factor. Nat Cell Biol. 3:839–843. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
77.
|
Gurbuxani S, Schmitt E, Cande C,
Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A,
Kroemer G and Garrido C: Heat shock protein 70 binding inhibits the
nuclear import of apoptosis-inducing factor. Oncogene.
22:6669–6678. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
78.
|
Matsumori Y, Hong SM, Aoyama K, Fan Y,
Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR and Liu
J: Hsp70 overexpression sequesters AIF and reduces neonatal
hypoxic/ischemic brain injury. J Cereb Blood Flow Metab.
25:899–910. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
79.
|
Kalinowska M, Garncarz W, Pietrowska M,
Garrard WT and Widlak P: Regulation of the human apoptotic
DNase/RNase endonuclease G: Involvement of Hsp70 and ATP.
Apoptosis. 10:821–830. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
80.
|
Sakahira H and Nagata S: Cotranslational
folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor
of caspase-activated DNase. J Biol Chem. 277:3364–3370. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
81.
|
Liu QL, Kishi H, Ohtsuka K and Muraguchi
A: Heat shock protein 70 binds caspase-activated DNase and enhances
its activity in TCR-stimulated T cells. Blood. 102:1788–1796. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
82.
|
Ribeil JA, Zermati Y, Vandekerckhove J,
Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A,
Kirkegaard-Sørensen T, Varet B, Solary E, Garrido C and Hermine O:
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated
cleavage of GATA-1. Nature. 445:102–105. 2007. View Article : Google Scholar
|
|
83.
|
Gyrd-Hansen M, Nylandsted J and Jaattela
M: Heat shock protein 70 promotes cancer cell viability by
safeguarding lysosomal integrity. Cell Cycle. 3:1484–1485. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
84.
|
Nylandsted J, Gyrd-Hansen M, Danielewicz
A, Fehrenbacher N, Lademann U, Hoyer-Hansen M, Weber E, Multhoff G,
Rohde M and Jaattela M: Heat shock protein 70 promotes cell
survival by inhibiting lysosomal membrane permeabilization. J Exp
Med. 200:425–435. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
85.
|
Leu JI, Pimkina J, Frank A, Murphy ME and
George DL: A small molecule inhibitor of inducible heat shock
protein 70. Mol Cell. 36:15–27. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
86.
|
Schmitt E, Maingret L, Puig PE, Rerole AL,
Ghiringhelli F, Hammann A, Solary E, Kroemer G and Garrido C:
Heat-shock protein 70 neutralization exerts potent antitumor
effects in animal models of colon cancer and melanoma. Cancer Res.
66:4191–4197. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
87.
|
Nadeau K, Nadler SG, Saulnier M, Tepper MA
and Walsh CT: Quantitation of the interaction of the
immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90.
Biochemistry. 33:2561–2567. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
88.
|
Fewell SW, Day BW and Brodsky JL:
Identification of an inhibitor of hsc70-mediated protein
translocation and ATP hydrolysis. J Biol Chem. 276:910–914. 2001.
View Article : Google Scholar
|
|
89.
|
Rodina A, Vilenchik M, Moulick K, Aguirre
J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts
S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW and Chiosis
G: Selective compounds define Hsp90 as a major inhibitor of
apoptosis in small-cell lung cancer. Nat Chem Biol. 3:498–507.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
90.
|
Wright CM, Seguin SP, Fewell SW, Zhang H,
Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM and
Brodsky JL: Inhibition of SimianVirus 40 replication by targeting
the molecular chaperone function and ATPase activity of T antigen.
Virus Res. 141:71–80. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
91.
|
Massey AJ, Williamson DS, Browne H, Murray
JB, Dokurno P, Shaw T, Macias AT, Daniels Z, Geoffroy S, Dopson M,
Lavan P, Matassova N, Francis GL, Graham CJ, Parsons R, Wang Y,
Padfield A, Comer M, Drysdale MJ and Wood M: A novel, small
molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor
induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother
Pharmacol. 66:535–545. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
92.
|
Jinwal UK, Miyata Y, Koren J III, Jones
JR, Trotter JH, Chang L, O’Leary J, Morgan D, Lee DC, Shults CL,
Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE and Dickey CA:
Chemical manipulation of hsp70 ATPase activity regulates tau
stability. J Neurosci. 29:12079–88. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
93.
|
Wadhwa R, Sugihara T, Yoshida A, Nomura H,
Reddel RR, Simpson R, Maruta H and Kaul SC: Selective toxicity of
MKT-077 to cancer cells is mediated by its binding to the hsp70
family protein mot-2 and reactivation of p53 function. Cancer Res.
60:6818–6821. 2000.PubMed/NCBI
|
|
94.
|
Wadhwa R, Yaguchi T, Hasan MK, Mitsui Y,
Reddel RR and Kaul SC: Hsp70 family member, mot-2/mthsp70/GRP75,
binds to the cytoplasmic sequestration domain of the p53 protein.
Exp Cell Res. 274:246–253. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
95.
|
Britten CD, Rowinsky EK, Baker SD, Weiss
GR, Smith L, Stephenson J, Rothenberg M, Smetzer L, Cramer J,
Collins W, Von Hoff DD and Eckhardt SG: A phase I and
pharmacokinetic study of the mitochondrial-specific rhodacyanine
dye analog MKT 077. Clin Cancer Res. 6:42–49. 2000.PubMed/NCBI
|
|
96.
|
Williams DR, Ko SK, Park S, Lee MR and
Shin I: An apoptosis-inducing small molecule that binds to heat
shock protein 70. Angew Chem Int Ed Engl. 47:7466–7469. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
97.
|
Powers MV, Jones K, Barillari C, Westwood
I, van Montfort RL and Workman P: Targeting HSP70: the second
potentially druggable heat shock protein and molecular chaperone?
Cell Cycle. 9:1542–1550. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
98.
|
Whetstone H and Lingwood C:
3’Sulfogalactolipid binding specifically inhibits Hsp70 ATPase
activity in vitro. Biochemistry. 42:1611–1617. 2003.
|
|
99.
|
Chatterjee M, Andrulis M, Stühmer T,
Müller E, Hofmann C, Steinbrunn T, Heimberger T, Schraud H,
Kressmann S, Einsele H and Bargou RC: The PI3K/Akt signaling
pathway regulates the expression of Hsp70, which critically
contributes to Hsp90-chaperone function and tumor cell survival in
multiple myeloma. Haematologica. 98:1132–1141. 2013. View Article : Google Scholar
|
|
100.
|
Multhoff G and Radons J: Radiation,
inflammation, and immune responses in cancer. Front Oncol.
2:582012. View Article : Google Scholar : PubMed/NCBI
|
|
101.
|
Stangl S, Gehrmann M, Riegger J, Kuhs K,
Riederer I, Sievert W, Hube K, Mocikat R, Dressel R, Kremmer E,
Pockley AG, Friedrich L, Vigh L, Skerra A and Multhoff G: Targeting
membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1
antibody. Proc Nat Acad Sci USA. 108:733–738. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
102.
|
Krause SW, Gastpar R, Andreesen R, Gross
C, Ullrich H, Thonigs G, Pfister K and Multhoff G: Treatment of
colon and lung cancer patients with ex vivo heat shock protein
70-peptide-activated, autologous natural killer cells: a clinical
phase I trial. Clin Cancer Res. 10:3699–3707. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
103.
|
Whitesell L and Lindquist SL: HSP90 and
the chaperoning of cancer. Nat Rev Cancer. 5:761–772. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
104.
|
Taipale M, Jarosz DF and Lindquist S:
HSP90 at the hub of protein homeostasis: emerging mechanistic
insights. Nat Rev Mol Cell Biol. 11:515–528. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
105.
|
Sreedhar AS, Kalmár E, Csermely P and Shen
YF: Hsp90 isoforms: functions, expression and clinical importance.
FEBS Lett. 562:11–15. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
106.
|
Hartl FU, Bracher A and Hayer-Hartl M:
Molecular chaperones in protein folding and proteostasis. Nature.
475:324–332. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
107.
|
Onuoha SC, Coulstock ET, Grossmann JG and
Jackson SE: Structural studies on the co-chaperone Hop and its
complexes with Hsp90. J Mol Biol. 379:732–744. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
108.
|
Mayer MP: Gymnastics of molecular
chaperones. Mol Cell. 39:321–331. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
109.
|
Krukenberg KA, Street TO, Lavery LA and
Agard DA: Conformational dynamics of the molecular chaperone Hsp90.
Q Rev Biophys. 44:229–255. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
110.
|
Ali MM, Roe SM, Vaughan CK, Meyer P,
Panaretou B and Piper PW: Crysta l structure of an
Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature.
440:1013–1017. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
111.
|
Normant E, Paez G and West KA: The Hsp90
inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor
regression in ALK-driven NSCLC models. Oncogene. 30:2581–2586.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
112.
|
Neckers L and Workman P: HSP90 molecular
chaperone inhibitors: are we there yet? Clin Cancer Res. 18:64–76.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
113.
|
Modi S, Stopeck A and Linden H: HSP90
inhibition is effective in breast cancer: a phase II trial of
tanespimycin (17-AAG) plus trastuzumab in patients with
HER2-positive metastatic breast cancer progressing on trastuzumab.
Clin Cancer Res. 17:5132–5139. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
114.
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
115.
|
Khong T and Spencer A: Targeting HSP 90
induces apoptosis and inhibits critical survival and proliferation
pathways in multiple myeloma. Mol Cancer Ther. 10:1909–1917. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
116.
|
Workman P, Burrows F, Neckers L and Rosen
N: Drugging the cancer chaperone HSP90: combinatorial therapeutic
exploitation of oncogene addiction and tumor stress. Ann NY Acad
Sci. 1113:202–216. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
117.
|
Hartl FU: Chaperone-assisted protein
folding: the path to discovery from a personal perspective. Nat
Med. 17:1206–1210. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
118.
|
Tiroli-Cepeda AO and Ramos CH: An overview
of the role of molecular chaperones in protein homeostasis. Protein
Pept Lett. 18:101–109. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
119.
|
Patel HJ, Modi S, Chiosis G and Taldone T:
Advances in the discovery and development of heat-shock protein 90
inhibitors for cancer treatment. Expert Opin Drug Discov.
6:559–587. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
120.
|
Sequist LV, Gettinger S and Natale R: A
phase II trial of IPI-504 (retaspimycin hydrochloride), a novel
Hsp90 inhibitor, in patients with relapsed and/or refractory stage
IIIb or stage IV non-small cell lung cancer (NSCLC) stratified by
EGFR mutation status. J Clin Oncol. 27:15s2009.
|
|
121.
|
McCollum AK, Teneyck CJ, Sauer BM, Toft DO
and Erlichman C: Up-regulation of heat shock protein 27 induces
resistance to 17-allylamino-demethoxy geldanamycin through a
glutathione-mediated mechanism. Cancer Res. 66:10967–10975. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
122.
|
Didelot C, Lanneau D, Brunet M, Bouchot A,
Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis
G, Dubrez-Daloz L, Solary E and Garrido C: Interaction of
heat-shock protein 90 beta isoform (HSP90 beta) with cellular
inhibitor of apoptosis 1 (c-IAP1) is required for cell
differentiation. Cell Death Differ. 15:859–866. 2008. View Article : Google Scholar
|
|
123.
|
Eustace BK, Sakurai T, Stewart JK,
Yimlamai D, Unger C, Zehetmeier C, Lain B, Torella C, Henning SW,
Beste G, Scroggins BT, Neckers L, Ilag LL and Jay DG: Functional
proteomic screens reveal an essential extracellular role for hsp90
alpha in cancer cell invasiveness. Nat Cell Biol. 6:507–514. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
124.
|
Wang X, Song X, Zhuo W, Fu Y, Shi H, Liang
Y, Tong M, Chang G and Luo Y: The regulatory mechanism of Hsp90
alpha secretion and its function in tumor malignancy. Proc Natl
Acad Sci USA. 106:21288–21293. 2009. View Article : Google Scholar : PubMed/NCBI
|