|
1.
|
Parkin DM, Bray F, Ferlay J and Pisani P:
Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005.
View Article : Google Scholar
|
|
2.
|
Venook AP, Papandreou C, Furuse J and de
Guevara LL: The incidence and epidemiology of hepatocellular
carcinoma: A global and regional perspective. Oncologist. 15:5–13.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
3.
|
Witters LA: The blooming of the French
lilac. J Clin Invest. 108:1105–1107. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Barriere G, Tartary M and Rigaud M:
Metformin: A rising star to fight the epithelial mesenchymal
transition in oncology. Anticancer Agents Med Chem. 13:333–340.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
5.
|
Lee MS, Hsu CC, Wahlqvist ML, Tsai HN,
Chang YH and Huang YC: Type 2 diabetes increases and metformin
reduces total, colorectal, liver and pancreatic cancer incidences
in taiwanese: A representative population prospective cohort study
of 800,000 individuals. BMC Cancer. 11:202011. View Article : Google Scholar
|
|
6.
|
Ben Sahra I, Laurent K, Loubat A, et al:
The antidiabetic drug metformin exerts an antitumoral effect in
vitro and in vivo through a decrease of cyclin D1 level. Oncogene.
27:3576–3586. 2008.PubMed/NCBI
|
|
7.
|
Brown KA, Hunger NI, Docanto M and Simpson
ER: Metformin inhibits aromatase expression in human breast adipose
stromal cells via stimulation of AMP-activated protein kinase.
Breast Cancer Res Treat. 123:591–596. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Hosono K, Endo H, Takahashi H, et al:
Metformin suppresses azoxymethane-induced colorectal aberrant crypt
foci by activating AMP-activated protein kinase. Mol Carcinog.
49:662–671. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Zhou XZ, Xue YM, Zhu B and Sha JP: Effects
of metformin on proliferation of human colon carcinoma cell line
SW-480. Nan Fang Yi Ke Da Xue Xue Bao. 30:1935–1938. 2010.(In
Chinese).
|
|
10.
|
Kato K, Gong J, Iwama H, et al: The
antidiabetic drug metformin inhibits gastric cancer cell
proliferation in vitro and in vivo. Mol Cancer Ther. 11:549–560.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
11.
|
Kobayashi M, Kato K, Iwama H, et al:
Antitumor effect of metformin in esophageal cancer: In vitro
study. Int J Oncol. 42:517–524. 2012.PubMed/NCBI
|
|
12.
|
Qu Z, Zhang Y, Liao M, Chen Y, Zhao J and
Pan Y: In vitro and in vivo antitumoral action of metformin on
hepatocellular carcinoma. Hepatol Res. 42:922–933. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
13.
|
Landgraf P, Rusu M, Sheridan R, et al: A
mammalian microRNA expression atlas based on small RNA library
sequencing. Cell. 129:1401–1414. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Ji J, Yamashita T, Budhu A, et al:
Identification of microRNA-181 by genome-wide screening as a
critical player in EpCAM-positive hepatic cancer stem cells.
Hepatology. 50:472–480. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Callegari E, Elamin BK, Giannone F, et al:
Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic
model. Hepatology. 56:1025–1033. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Masaki T, Shiratori Y, Rengifo W, et al:
Hepatocellular carcinoma cell cycle: Study of long-evans cinnamon
rats. Hepatology. 32:711–720. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Masaki T, Shiratori Y, Rengifo W, et al:
Cyclins and cyclin-dependent kinases: Comparative study of
hepatocellular carcinoma versus cirrhosis. Hepatology. 37:534–543.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Masaki T, Tokuda M, Yoshida S, et al:
Comparison study of the expressions of myristoylated alanine-rich C
kinase substrate in hepatocellular carcinoma, liver cirrhosis,
chronic hepatitis, and normal liver. Int J Oncol. 26:661–671.
2005.
|
|
19.
|
Bradford MM: A rapid and sensitive method
for the quantitation of microgram quantities of protein utilizing
the principle of protein-dye binding. Anal Biochem. 72:248–254.
1976. View Article : Google Scholar : PubMed/NCBI
|
|
20.
|
Towbin H, Staehelin T and Gordon J:
Electrophoretic transfer of proteins from polyacrylamide gels to
nitrocellulose sheets: Procedure and some applications. Proc Natl
Acad Sci USA. 76:4350–4354. 1979. View Article : Google Scholar : PubMed/NCBI
|
|
21.
|
Workman P, Aboagye EO, Balkwill F, et al:
Guidelines for welfare and use of animals in cancer research. Br J
Cancer. 102:1555–1577. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
D’Incalci M, Colombo T, Ubezio P, et al:
The combination of yondelis and cisplatin is synergistic against
human tumor xenografts. Eur J Cancer. 39:1920–1926. 2003.
|
|
23.
|
Masaki T, Morishita A, Kurokohchi K and
Kuriyama S: Multidisciplinary treatment of patients with
hepatocellular carcinoma. Expert Rev Anticancer Ther. 6:1377–1384.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
24.
|
Liu B, Fan Z, Edgerton SM, Deng XS,
Alimova IN, Lind SE and Thor AD: Metformin induces unique
biological and molecular responses in triple negative breast cancer
cells. Cell Cycle. 8:2031–2040. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
25.
|
Gong J, Morishita A, Kurokohchi K, et al:
Use of protein array to investigate receptor tyrosine kinases
activated in gastric cancer. Int J Oncol. 36:101–106.
2010.PubMed/NCBI
|
|
26.
|
Wang LW, Li ZS, Zou DW, Jin ZD, Gao J and
Xu GM: Metformin induces apoptosis of pancreatic cancer cells.
World J Gastroenterol. 14:7192–7198. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Verma A, Warner SL, Vankayalapati H,
Bearss DJ and Sharma S: Targeting Axl and Mer kinases in cancer.
Mol Cancer Ther. 10:1763–1773. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Guttridge KL, Luft JC, Dawson TL,
Kozlowska E, Mahajan NP, Varnum B and Earp HS: Mer receptor
tyrosine kinase signaling: Prevention of apoptosis and alteration
of cytoskeletal architecture without stimulation or proliferation.
J Biol Chem. 277:24057–24066. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
29.
|
Sainaghi PP, Castello L, Bergamasco L,
Galletti M, Bellosta P and Avanzi GC: Gas6 induces proliferation in
prostate carcinoma cell lines expressing the axl receptor. J Cell
Physiol. 204:36–44. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Li S and Hu GF: Angiogenin-mediated rRNA
transcription in cancer and neurodegeneration. Int J Biochem Mol
Biol. 1:26–35. 2010.
|
|
31.
|
Hisai H, Kato J, Kobune M, et al:
Increased expression of angiogenin in hepatocellular carcinoma in
correlation with tumor vascularity. Clin Cancer Res. 9:4852–4859.
2003.PubMed/NCBI
|
|
32.
|
Boyerinas B, Park SM, Hau A, Murmann AE
and Peter ME: The role of let-7 in cell differentiation and cancer.
Endocr Relat Cancer. 17:F19–F36. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Takamizawa J, Konishi H, Yanagisawa K, et
al: Reduced expression of the let-7 microRNAs in human lung cancers
in association with shortened postoperative survival. Cancer Res.
64:3753–3756. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
34.
|
Yu F, Yao H, Zhu P, et al: Let-7 regulates
self renewal and tumorigenicity of breast cancer cells. Cell.
131:1109–1123. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Akao Y, Nakagawa Y and Naoe T: Let-7
microRNA functions as a potential growth suppressor in human colon
cancer cells. Biol Pharm Bull. 29:903–906. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Fu TY, Chang CC, Lin CT, Lai CH, Peng SY,
Ko YJ and Tang PC: Let-7b-mediated suppression of basigin
expression and metastasis in mouse melanoma cells. Exp Cell Res.
317:445–451. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Zhu XM, Wu LJ, Xu J, Yang R and Wu FS:
Let-7c microRNA expression and clinical significance in
hepatocellular carcinoma. J Int Med Res. 39:2323–2329. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
38.
|
Johnson SM, Grosshans H, Shingara J, et
al: RAS is regulated by the let-7 microRNA family. Cell.
120:635–647. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
39.
|
Lee YS and Dutta A: The tumor suppressor
microRNA let-7 represses the HMGA2 oncogene. Genes Dev.
21:1025–1030. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
40.
|
Osada H and Takahashi T: Let-7 and
miR-17-92: Small-sized major players in lung cancer development.
Cancer Sci. 102:9–17. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
41.
|
Haybaeck J, Zeller N and Heikenwalder M:
The parallel universe: MicroRNAs and their role in chronic
hepatitis, liver tissue damage and hepatocarcinogenesis. Swiss Med
Wkly. 141:w132872011.PubMed/NCBI
|
|
42.
|
Borel F, Konstantinova P and Jansen PL:
Diagnostic and therapeutic potential of miRNA signatures in
patients with hepatocellular carcinoma. J Hepatol. 56:1371–1383.
2012. View Article : Google Scholar : PubMed/NCBI
|
