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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2014 Volume 45 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway

  • Authors:
    • Zhen-Hai Lin
    • Liying Wang
    • Ju-Bo Zhang
    • Yanfeng Liu
    • Xiao-Qiang Li
    • Lei Guo
    • Bo Zhang
    • Wen-Wei Zhu
    • Qing-Hai Ye
  • View Affiliations / Copyright

    Affiliations: Liver Cancer Institute and Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China, The Second Artillery General Hospital of Chinese People's Liberation Army, Beijing, P.R. China, Key Laboratory of Medical Molecular Virology (MOE and MOH), Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China
  • Pages: 629-640
    |
    Published online on: May 22, 2014
       https://doi.org/10.3892/ijo.2014.2455
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Abstract

Mammalian sterile-20-like kinase 4 (MST4) has been implicated in cell proliferation and differentiation. In a previous study, we found MST4 to be an important candidate gene for metastatic hepatocellular carcinoma (HCC); however, the molecular mechanism of the promoting role of MST4 in HCC metastasis is poorly understood. In this study, we show that high expression of MST4 was detected in highly invasive HCC cells and in human HCC specimens with vascular invasion. A high level of MST4, associated with large tumor size, microvascular invasion, presence of intrahepatic metastasis, and advanced TNM classification of malignant tumors stage, was an independent prognostic factor for overall survival (P=0.004) and time to recurrence (P=0.001) after hepatectomy. Knockdown of MST4 expression in HCC cells inhibited cell proliferation, colony formation, and invasion, whereas upregulation of MST4 significantly promoted these processes by promoting epithelial-mesenchymal transition (EMT), dependent on the activation of extracellular signal-regulated protein kinase (ERK) signaling pathways. Furthermore, the combination of MST4 and phosphorylated ERK was proven to have more power to predict the outcomes of HCC patients. This study presents clinical evidence for predicting the value of MST4 in HCC overall survival and recurrence and describes the key role of MST4 in facilitating the EMT process via regulating the activation of ERK, indicating its potential role as a target for postoperative adjuvant therapy for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Lin Z, Wang L, Zhang J, Liu Y, Li X, Guo L, Zhang B, Zhu W and Ye Q: MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Int J Oncol 45: 629-640, 2014.
APA
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L. ... Ye, Q. (2014). MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. International Journal of Oncology, 45, 629-640. https://doi.org/10.3892/ijo.2014.2455
MLA
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L., Zhang, B., Zhu, W., Ye, Q."MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway". International Journal of Oncology 45.2 (2014): 629-640.
Chicago
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L., Zhang, B., Zhu, W., Ye, Q."MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway". International Journal of Oncology 45, no. 2 (2014): 629-640. https://doi.org/10.3892/ijo.2014.2455
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Z, Wang L, Zhang J, Liu Y, Li X, Guo L, Zhang B, Zhu W and Ye Q: MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Int J Oncol 45: 629-640, 2014.
APA
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L. ... Ye, Q. (2014). MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. International Journal of Oncology, 45, 629-640. https://doi.org/10.3892/ijo.2014.2455
MLA
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L., Zhang, B., Zhu, W., Ye, Q."MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway". International Journal of Oncology 45.2 (2014): 629-640.
Chicago
Lin, Z., Wang, L., Zhang, J., Liu, Y., Li, X., Guo, L., Zhang, B., Zhu, W., Ye, Q."MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway". International Journal of Oncology 45, no. 2 (2014): 629-640. https://doi.org/10.3892/ijo.2014.2455
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