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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2014 Volume 45 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients

  • Authors:
    • Lun Dong
    • Yuping Li
    • Chongxu Han
    • Xiaodong Wang
    • Lei She
    • Hengzhu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Central Laboratory, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 746-756
    |
    Published online on: May 22, 2014
       https://doi.org/10.3892/ijo.2014.2459
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Abstract

MicroRNAs (miRNAs) are frequently dysregulated in glioblastoma (GBM) patients. It has been discovered that highly stable extracellular miRNAs circulate in the blood of both healthy individuals and patients. miRNAs in serum of patients with GBM and normal controls were analyzed by microarray analysis. The relevant bioinformatic analysis of the predicted target genes (gene ontology, pathway, gene network analysis) were performed. The miRNA microarray reveals differentially expressed miRNAs in serum between the GBM and normal controls. Of the 752 miRNAs, 115 miRNAs were upregulated in the GBM group, and 24 miRNAs were downregulated (fold change ≥2.0, P<0.01). By further analysis, we found that miR-576-5p, miR-340 and miR-626 were significantly overexpressed, but miR-320, let-7g-5p and miR-7-5P showed significantly low expression in GBM patients. By further bioinformatic analysis, we found that they possibly play important roles in the regulation of glioma signaling pathways. In summary, the six miRNAs are significant distinct in the peripheral blood of patients with GBM pathologies. These data suggest that the miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity.
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Copy and paste a formatted citation
Spandidos Publications style
Dong L, Li Y, Han C, Wang X, She L and Zhang H: miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. Int J Oncol 45: 746-756, 2014.
APA
Dong, L., Li, Y., Han, C., Wang, X., She, L., & Zhang, H. (2014). miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. International Journal of Oncology, 45, 746-756. https://doi.org/10.3892/ijo.2014.2459
MLA
Dong, L., Li, Y., Han, C., Wang, X., She, L., Zhang, H."miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients". International Journal of Oncology 45.2 (2014): 746-756.
Chicago
Dong, L., Li, Y., Han, C., Wang, X., She, L., Zhang, H."miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients". International Journal of Oncology 45, no. 2 (2014): 746-756. https://doi.org/10.3892/ijo.2014.2459
Copy and paste a formatted citation
x
Spandidos Publications style
Dong L, Li Y, Han C, Wang X, She L and Zhang H: miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. Int J Oncol 45: 746-756, 2014.
APA
Dong, L., Li, Y., Han, C., Wang, X., She, L., & Zhang, H. (2014). miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. International Journal of Oncology, 45, 746-756. https://doi.org/10.3892/ijo.2014.2459
MLA
Dong, L., Li, Y., Han, C., Wang, X., She, L., Zhang, H."miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients". International Journal of Oncology 45.2 (2014): 746-756.
Chicago
Dong, L., Li, Y., Han, C., Wang, X., She, L., Zhang, H."miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients". International Journal of Oncology 45, no. 2 (2014): 746-756. https://doi.org/10.3892/ijo.2014.2459
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