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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2014 Volume 45 Issue 2

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

  • Authors:
    • Habibie Habibie
    • Satoru Yokoyama
    • Sherif Abdelhamed
    • Suresh Awale
    • Hiroaki Sakurai
    • Yoshihiro Hayakawa
    • Ikuo Saiki
  • View Affiliations / Copyright

    Affiliations: Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan, Frontier Research Core for Life Sciences, University of Toyama, Toyama 930-0194, Japan
  • Pages: 895-901
    |
    Published online on: June 3, 2014
       https://doi.org/10.3892/ijo.2014.2480
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Abstract

Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell lines, we show that survivin is essential for melanoma survival in vitro and in vivo and is targeted by resveratrol. Furthermore, we identify the downregulation of survivin transcription by resveratrol through the suppression of β-catenin and STAT3. In addition, overexpression of survivin protects melanoma cells from resveratrol-induced apoptosis. Collectively, these studies establish that targeting survivin could provide an opportunity to treat melanoma patients.
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1 

Chudnovsky Y, Khavari PA and Adams AE: Melanoma genetics and the development of rational therapeutics. J Clin Invest. 115:813–824. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Devesa SS, Fears TR and Hartge P: Cancer surveillance series: changing patterns of cutaneous malignant melanoma mortality rates among whites in the United States. J Natl Cancer Inst. 92:811–818. 2000. View Article : Google Scholar

3 

Jemal A, Devesa SS, Hartge P and Tucker MA: Recent trends in cutaneous melanoma incidence among whites in the United States. J Natl Cancer Inst. 93:678–683. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar

5 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar

6 

Flaherty KT, Puzanov I, Kim KB, et al: Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 363:809–819. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Nashan D, Muller ML, Grabbe S, Wustlich S and Enk A: Systemic therapy of disseminated malignant melanoma: an evidence-based overview of the state-of-the-art in daily routine. J Eur Acad Dermatol Venereol. 21:1305–1318. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Petrovski G, Gurusamy N and Das DK: Resveratrol in cardiovascular health and disease. Ann NY Acad Sci. 1215:22–33. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Szkudelska K and Szkudelski T: Resveratrol, obesity and diabetes. Eur J Pharmacol. 635:1–8. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Signorelli P and Ghidoni R: Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem. 16:449–466. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y: Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24:2783–2840. 2004.PubMed/NCBI

12 

Niles RM, McFarland M, Weimer MB, Redkar A, Fu YM and Meadows GG: Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett. 190:157–163. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Fulda S and Debatin KM: Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene. 23:6702–6711. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H and Hei TK: Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res. 314:1163–1176. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Fulda S and Debatin KM: Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 64:337–346. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Fang Y, Bradley MJ, Cook KM, Herrick EJ and Nicholl MB: A potential role for resveratrol as a radiation sensitizer for melanoma treatment. J Surg Res. 183:645–653. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Kim MY: Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep. 5:585–591. 2012.PubMed/NCBI

18 

Osmond GW, Augustine CK, Zipfel PA, Padussis J and Tyler DS: Enhancing melanoma treatment with resveratrol. J Surg Res. 172:109–115. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Tak JK, Lee JH and Park JW: Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep. 45:242–246. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Sakurai H, Suzuki S, Kawasaki N, et al: Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem. 278:36916–36923. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Haq R, Yokoyama S, Hawryluk EB, et al: BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci USA. 110:4321–4326. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Trapp V, Parmakhtiar B, Papazian V, Willmott L and Fruehauf JP: Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis. 13:305–315. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Altieri DC: Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer. 8:61–70. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Zhang J, Chiu J, Zhang H, et al: Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Biochem Pharmacol. 86:317–328. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Jiang H, Shang X, Wu H, et al: Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol. 8:25–33. 2009.PubMed/NCBI

26 

Vaira V, Lee CW, Goel HL, Bosari S, Languino LR and Altieri DC: Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. 26:2678–2684. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Zhao W, Bao P, Qi H and You H: Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells. Oncol Rep. 23:279–286. 2010.PubMed/NCBI

28 

Hayashibara T, Yamada Y, Nakayama S, et al: Resveratrol induces downregulation in survivin expression and apoptosis in HTLV-1-infected cell lines: a prospective agent for adult T cell leukemia chemotherapy. Nutr Cancer. 44:193–201. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Shankar S, Siddiqui I and Srivastava RK: Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells. Mol Cell Biochem. 304:273–285. 2007. View Article : Google Scholar

30 

Singh SK, Moretta D, Almaguel F, Wall NR, De Leon M and De Leon D: Differential effect of proIGF-II and IGF-II on resveratrol induced cell death by regulating survivin cellular localization and mitochondrial depolarization in breast cancer cells. Growth Factors. 25:363–372. 2007. View Article : Google Scholar

31 

Singh RP, Tyagi A, Sharma G, Mohan S and Agarwal R: Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res. 14:300–308. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Talantov D, Mazumder A, Yu JX, et al: Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res. 11:7234–7242. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Velculescu VE, Madden SL, Zhang L, et al: Analysis of human transcriptomes. Nat Genet. 23:387–388. 1999. View Article : Google Scholar

34 

Adhami VM, Afaq F and Ahmad N: Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia. 5:74–82. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Widlund HR, Horstmann MA, Price ER, et al: Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 158:1079–1087. 2002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Habibie H, Yokoyama S, Abdelhamed S, Awale S, Sakurai H, Hayakawa Y and Saiki I: Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. Int J Oncol 45: 895-901, 2014.
APA
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., & Saiki, I. (2014). Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. International Journal of Oncology, 45, 895-901. https://doi.org/10.3892/ijo.2014.2480
MLA
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., Saiki, I."Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis". International Journal of Oncology 45.2 (2014): 895-901.
Chicago
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., Saiki, I."Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis". International Journal of Oncology 45, no. 2 (2014): 895-901. https://doi.org/10.3892/ijo.2014.2480
Copy and paste a formatted citation
x
Spandidos Publications style
Habibie H, Yokoyama S, Abdelhamed S, Awale S, Sakurai H, Hayakawa Y and Saiki I: Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. Int J Oncol 45: 895-901, 2014.
APA
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., & Saiki, I. (2014). Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. International Journal of Oncology, 45, 895-901. https://doi.org/10.3892/ijo.2014.2480
MLA
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., Saiki, I."Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis". International Journal of Oncology 45.2 (2014): 895-901.
Chicago
Habibie, H., Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y., Saiki, I."Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis". International Journal of Oncology 45, no. 2 (2014): 895-901. https://doi.org/10.3892/ijo.2014.2480
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