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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2014 Volume 45 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Review Open Access

Emerging targeted therapies for melanoma treatment (Review)

  • Authors:
    • Angela Russo
    • Bartolomea Ficili
    • Saverio Candido
    • Franca Maria Pezzino
    • Claudio Guarneri
    • Antonio Biondi
    • Salvatore Travali
    • James A. McCubrey
    • Demetrios A. Spandidos
    • Massimo Libra
  • View Affiliations / Copyright

    Affiliations: Laboratory of Translational Oncology and Functional Genomics, Section of General Pathology and Oncology, Department of Biomedical Sciences, University of Catania, I-95124 Catania, Italy, Department of Social Territorial Medicine, Section of Dermatology, University of Messina, I-98125 Messina, Italy, Department of Surgery, University of Catania, I-95124 Catania, Italy, Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA, Department of Virology, Medical School, University of Crete, Heraklion 71003, Crete, Greece
    Copyright: © Russo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 516-524
    |
    Published online on: June 3, 2014
       https://doi.org/10.3892/ijo.2014.2481
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Abstract

Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) and the PI3K/AKT (AKT) signalling pathways are constitutively activated through multiple mechanisms. Targeting various effectors of these pathways with pharmacologic inhibitors may inhibit melanoma cell growth and angiogenesis. Ongoing clinical trials provide hope to improve progression-free survival of patients with advanced melanoma. This review summarizes the most relevant studies focused on the specific action of these new molecular targeted agents. Mechanisms of resistance to therapy are also discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Russo A, Ficili B, Candido S, Pezzino FM, Guarneri C, Biondi A, Travali S, McCubrey JA, Spandidos DA, Libra M, Libra M, et al: Emerging targeted therapies for melanoma treatment (Review). Int J Oncol 45: 516-524, 2014.
APA
Russo, A., Ficili, B., Candido, S., Pezzino, F.M., Guarneri, C., Biondi, A. ... Libra, M. (2014). Emerging targeted therapies for melanoma treatment (Review). International Journal of Oncology, 45, 516-524. https://doi.org/10.3892/ijo.2014.2481
MLA
Russo, A., Ficili, B., Candido, S., Pezzino, F. M., Guarneri, C., Biondi, A., Travali, S., McCubrey, J. A., Spandidos, D. A., Libra, M."Emerging targeted therapies for melanoma treatment (Review)". International Journal of Oncology 45.2 (2014): 516-524.
Chicago
Russo, A., Ficili, B., Candido, S., Pezzino, F. M., Guarneri, C., Biondi, A., Travali, S., McCubrey, J. A., Spandidos, D. A., Libra, M."Emerging targeted therapies for melanoma treatment (Review)". International Journal of Oncology 45, no. 2 (2014): 516-524. https://doi.org/10.3892/ijo.2014.2481
Copy and paste a formatted citation
x
Spandidos Publications style
Russo A, Ficili B, Candido S, Pezzino FM, Guarneri C, Biondi A, Travali S, McCubrey JA, Spandidos DA, Libra M, Libra M, et al: Emerging targeted therapies for melanoma treatment (Review). Int J Oncol 45: 516-524, 2014.
APA
Russo, A., Ficili, B., Candido, S., Pezzino, F.M., Guarneri, C., Biondi, A. ... Libra, M. (2014). Emerging targeted therapies for melanoma treatment (Review). International Journal of Oncology, 45, 516-524. https://doi.org/10.3892/ijo.2014.2481
MLA
Russo, A., Ficili, B., Candido, S., Pezzino, F. M., Guarneri, C., Biondi, A., Travali, S., McCubrey, J. A., Spandidos, D. A., Libra, M."Emerging targeted therapies for melanoma treatment (Review)". International Journal of Oncology 45.2 (2014): 516-524.
Chicago
Russo, A., Ficili, B., Candido, S., Pezzino, F. M., Guarneri, C., Biondi, A., Travali, S., McCubrey, J. A., Spandidos, D. A., Libra, M."Emerging targeted therapies for melanoma treatment (Review)". International Journal of Oncology 45, no. 2 (2014): 516-524. https://doi.org/10.3892/ijo.2014.2481
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