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Article Open Access

Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells

  • Authors:
    • Zhongyun Dong
    • Jaroslaw Meller
    • Paul Succop
    • Jiang Wang
    • Kathryn Wikenheiser-Brokamp
    • Sandra Starnes
    • Shan Lu
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA, Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 978-984
    |
    Published online on: June 10, 2014
       https://doi.org/10.3892/ijo.2014.2486
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Abstract

Lung cancer is the leading cause of cancer death worldwide. There is an urgent need for early diagnostic tools and novel therapies in order to increase lung cancer survival. Secretory phospholipase A2 group IIa (sPLA2-IIa) is involved in inflammation, tumorigenesis and metastasis. We were the first to uncover that cancer cells secrete sPLA2‑IIa. sPLA2‑IIa is overexpressed in almost all specimens of human lung cancers examined and is significantly elevated in the plasma of lung cancer patients. High levels of plasma sPLA2-IIa are significantly associated with advanced stage and decreased overall cancer survival. In this study, we further showed that elevated HER/HER2‑PI3K-Akt-NF-κB signaling contributes to sPLA2-IIa overexpression in lung cancer cells. sPLA2-IIa in turn phosphorylates and activates HER2 and HER3 in a time- and dose‑dependent manner in lung cancer cells. The structure and sequence‑based docking analysis revealed that sPLA2-IIa β hairpin shares structural similarity with the corresponding EGF hairpin. sPLA2-IIa forms an extensive interface with EGFR and brings the two lobes of EGFR into an active conformation. sPLA2-IIa also enhances the NF-κB promoter activity. Anti-sPLA2-IIa antibody, but not the small molecule sPLA2-IIa inhibitor LY315920, significantly inhibits sPLA2‑IIa-induced activation of NF-κB promoter. Our findings support the notion that sPLA2-IIa functions as a ligand for the EGFR family of receptors leading to an elevated HER/HER2-elicited signaling. Plasma sPLA2-IIa can potentially serve as lung cancer biomarker and sPLA2‑IIa is a potential therapeutic target against lung cancer.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

2 

Peters S, Adjei AA, Gridelli C, Reck M, Kerr K and Felip E: Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 23(Suppl 7): vii56–vii64. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Gridelli C, Ardizzoni A, Douillard JY, et al: Recent issues in first-line treatment of advanced non-small-cell lung cancer: Results of an International Expert Panel Meeting of the Italian Association of Thoracic Oncology. Lung Cancer. 68:319–331. 2010. View Article : Google Scholar

4 

Pisters KM, Evans WK, Azzoli CG, et al: Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I–IIIA resectable non small-cell lung cancer guideline. J Clin Oncol. 25:5506–5518. 2007.PubMed/NCBI

5 

Goffin J, Lacchetti C, Ellis PM, Ung YC and Evans WK: First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: a systematic review. J Thorac Oncol. 5:260–274. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Cataldo VD, Gibbons DL, Perez-Soler R and Quintas-Cardama A: Treatment of non-small-cell lung cancer with erlotinib or gefitinib. New Engl J Med. 364:947–955. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Gazdar AF: Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev. 29:37–48. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Tsao MS, Sakurada A, Cutz JC, et al: Erlotinib in lung cancer - molecular and clinical predictors of outcome. New Engl J Med. 353:133–144. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Munoz M, Henderson M, Haber M and Norris M: Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life. 59:752–757. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Modok S, Mellor HR and Callaghan R: Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer. Curr Opin Pharmacol. 6:350–354. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar

12 

Henschke CI, McCauley DI, Yankelevitz DF, et al: Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 354:99–105. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Wahidi MM, Govert JA, Goudar RK, Gould MK and McCrory DC: Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132:94S–107S. 2007. View Article : Google Scholar

14 

Starnes SL, Reed MF, Meyer CA, et al: Lung cancer screening with low-dose CT in an area endemic for Histoplasma Capsulatum: minimizing invasive procedures for benign nodules. J Thorac Cardiovasc Surg. 141:688–693. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Team TNLSTR. Reduced lung-cancer mortality with low-dose computed tomographic screening. New Engl J Med. 365:395–409. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lederle FA and Niewoehner DE: Lung cancer surgery. A critical review of the evidence. Arch Intern Med. 154:2397–2400. 1994. View Article : Google Scholar : PubMed/NCBI

17 

Cummings BS: Phospholipase A2 as targets for anti-cancer drugs. Biochem Pharmacol. 74:949–959. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Lambeau G and Lazdunski M: Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sci. 20:162–170. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Antonio V, Brouillet A, Janvier B, et al: Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-kappaB and Ets transcription factors. Biochem J. 368:415–424. 2002. View Article : Google Scholar

20 

Dong Z, Liu Y, Scott KF, et al: Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer. Carcinogenesis. 31:1948–1955. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Triggiani M, Granata F, Giannattasio G and Marone G: Secretory phospholipases A2 in inflammatory and allergic diseases: not just enzymes. Journal Allergy Clin Immunol. 116:1000–1006. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Meyer AM, Dwyer-Nield LD, Hurteau GJ, et al: Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Carcinogenesis. 25:1517–1524. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Kupert E, Anderson M, Liu Y, et al: Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC Cancer. 11:5132011. View Article : Google Scholar : PubMed/NCBI

24 

Lu S, Tsai SY and Tsai MJ: Molecular mechanisms of androgen-independent growth of human prostate cancer LNCaP-AI cells. Endocrinology. 140:5054–5059. 1999.PubMed/NCBI

25 

Oleksowicz L, Liu Y, Bracken RB, et al: Secretory phospholipase A2-IIa is a target gene of the HER/HER2-elicited pathway and potential plasma biomarker for poor prognosis of prostate cancer. Prostate. 72:1140–1149. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Schulze WX, Deng L and Mann M: Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 1:2005.00082005. View Article : Google Scholar

27 

Hsieh AC and Moasser MM: Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br J Cancer. 97:453–457. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lovly CM and Carbone DP: Lung cancer in 2010: One size does not fit all. Nat Rev Clin Oncol. 8:68–70. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Davies AM, Lara PN Jr, Mack PC and Gandara DR: Incorporating bortezomib into the treatment of lung cancer. Clin Cancer Res. 13:s4647–s4651. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Engelman JA and Cantley LC: The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res. 12:4372s–4376s. 2006. View Article : Google Scholar

31 

Tas SW, Vervoordeldonk MJ and Tak PP: Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer. Curr Gene Ther. 9:160–170. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Escobar M, Velez M, Belalcazar A, Santos ES and Raez LE: The role of proteasome inhibition in nonsmall cell lung cancer. J Biomed Biotechnol. 2011:8065062011. View Article : Google Scholar : PubMed/NCBI

33 

Sved P, Scott KF, McLeod D, et al: Oncogenic action of secreted phospholipase A2 in prostate cancer. Cancer Res. 64:6934–6940. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Patel MI, Singh J, Niknami M, et al: Cytosolic phospholipase A2-alpha: a potential therapeutic target for prostate cancer. Clin Cancer Res. 14:8070–8079. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Belinsky GS, Rajan TV, Saria EA, Giardina C and Rosenberg DW: Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth. Mol Carcinog. 46:106–116. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Mulherkar R, Kirtane BM, Ramchandani A, Mansukhani NP, Kannan S and Naresh KN: Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis. Oncogene. 22:1936–1944. 2003. View Article : Google Scholar

37 

Hernandez M, Martin R, Garcia-Cubillas MD, Maeso-Hernandez P and Nieto ML: Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link. Neuro Oncol. 12:1014–1023. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Martin R, Hernandez M, Ibeas E, et al: Secreted phospholipase A2-IIA modulates key regulators of proliferation on astrocytoma cells. J Neurochem. 111:988–999. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Narayanan BA, Narayanan NK, Pittman B and Reddy BS: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. Clin Cancer Res. 10:7727–7737. 2004. View Article : Google Scholar

40 

Kobayashi N, Barnard RJ, Henning SM, et al: Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 12:4662–4670. 2006. View Article : Google Scholar

41 

Dong Z, Liu Y, Levin L, Oleksowicz L, Wang J and Lu S: Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer. Oncol Rep. 25:1511–1516. 2011.

42 

Granata F, Frattini A, Loffredo S, et al: Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J Immunol. 184:5232–5241. 2010. View Article : Google Scholar

43 

Baek SH, Lim JH, Park DW, et al: Group IIA secretory phospholipase A(2) stimulates inducible nitric oxide synthase expression via ERK and NF-kappaB in macrophages. Eur J Immunol. 31:2709–2717. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Park DW, Kim JR, Kim SY, et al: Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression. J Immunol. 170:2093–2099. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Ibeas E, Fuentes L, Martin R, Hernandez M and Nieto ML: Inflammatory protein sPLA(2)-IIA abrogates TNFalpha-induced apoptosis in human astroglioma cells: Crucial role of ERK. Biochim Biophys Acta. 1793:1837–1847. 2009. View Article : Google Scholar

46 

Scott KF, Sajinovic M, Hein J, et al: Emerging roles for phospholipase A2 enzymes in cancer. Biochimie. 92:601–610. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Valentin E and Lambeau G: Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins. Biochim Biophys Acta. 1488:59–70. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Hernandez M, Burillo SL, Crespo MS and Nieto ML: Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1. J Biol Chem. 273:606–612. 1998. View Article : Google Scholar

49 

Yu JA, Mauchley D, Li H, et al: Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg. 144:1185–1191. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong Z, Meller J, Succop P, Wang J, Wikenheiser-Brokamp K, Starnes S and Lu S: Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. Int J Oncol 45: 978-984, 2014.
APA
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., & Lu, S. (2014). Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International Journal of Oncology, 45, 978-984. https://doi.org/10.3892/ijo.2014.2486
MLA
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., Lu, S."Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells". International Journal of Oncology 45.3 (2014): 978-984.
Chicago
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., Lu, S."Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells". International Journal of Oncology 45, no. 3 (2014): 978-984. https://doi.org/10.3892/ijo.2014.2486
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Z, Meller J, Succop P, Wang J, Wikenheiser-Brokamp K, Starnes S and Lu S: Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. Int J Oncol 45: 978-984, 2014.
APA
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., & Lu, S. (2014). Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International Journal of Oncology, 45, 978-984. https://doi.org/10.3892/ijo.2014.2486
MLA
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., Lu, S."Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells". International Journal of Oncology 45.3 (2014): 978-984.
Chicago
Dong, Z., Meller, J., Succop, P., Wang, J., Wikenheiser-Brokamp, K., Starnes, S., Lu, S."Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells". International Journal of Oncology 45, no. 3 (2014): 978-984. https://doi.org/10.3892/ijo.2014.2486
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