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Article

Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications

  • Authors:
    • Ramesh K. Wali
    • Thomas A. Hensing
    • Daniel W. Ray
    • Mart Dela Cruz
    • Ashish K. Tiwari
    • Andrew Radosevich
    • Lisa Jepeal
    • Hiran C. Fernando
    • Virginia R. Litle
    • Marjory Charlot
    • Navneet Momi
    • Vadim Backman
    • Hemant K. Roy
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA, Department of Surgery, NorthShore University Health Systems, Evanston, IL 60201, USA, Department of Medicine, NorthShore University Health Systems, Evanston, IL 60201, USA, Department of Medicine, Michigan State University, East Lansing, MI 48824, USA, Department of Biomedical Engineering, Northwestern University, Evanston, IL 60201, USA, Department of Surgery, Boston University Medical Center, Boston, MA 02118, USA
  • Pages: 1209-1215
    |
    Published online on: June 11, 2014
       https://doi.org/10.3892/ijo.2014.2495
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Abstract

MicroRNAs (miRNAs) have been shown to be reliable early biomarkers in a variety of cancers including that of lung. We ascertained whether the biomarker potential of miRNAs could be validated in microscopically normal and easily accessible buccal epithelial brushings from cigarette smokers as a consequence of lung cancer linked ‘field carcinogenesis’. We found that compared to neoplasia-free subjects, a panel of 68 miRNAs were upregulated and 3 downregulated in the normal appearing buccal mucosal cells collected from patients harboring lung cancer (n=76). The performance characteristics of selected miRNAs (with ≥1-fold change) were excellent with an average under the receiver operator characteristic curve (AUROC) of >0.80. Several miRNAs also displayed gender specificity between the groups. These results provide the first proof-of-concept scenario in which minimally intrusive cheek brushings could provide an initial screening tool in a large at-risk population.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar

2 

Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoppa S, Hachey M, Kirch R, Jemal A and Ward E: Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 62:220–241. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Alberg AJ, Ford JG and Samet JM: Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132:S29–S55. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bach PB, Silvestri GA, Hanger M and Jett JR: Screening for lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132:S69–S77. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM and Sicks JD: Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 365:395–409. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Kovalchik SA, Tammemagi M, Berg CD, Caporaso NE, Riley TL, Korch M, Silvestri GA, Chaturvedi AK and Katki HA: Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med. 369:245–254. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Moyer VA: Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 160:330–338. 2014.PubMed/NCBI

8 

Kopelovich L, Henson DE, Gazdar AF, Dunn B, Srivastava S, Kelloff GJ and Greenwald P: Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect. Clin Cancer Res. 5:3899–3905. 1999.PubMed/NCBI

9 

Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME and Spira A: Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 9:2592008. View Article : Google Scholar : PubMed/NCBI

10 

Sidransky D: The oral cavity as a molecular mirror of lung carcinogenesis. Cancer Prev Res. 1:12–14. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Us-Krasovec M, Erzen J, Zganec M, Strojan-Flezar M, Lavrencak J, Garner D, Doudkine A and Palcic B: Malignancy associated changes in epithelial cells of buccal mucosa: a potential cancer detection test. Anal Quant Cytol Histol. 27:254–262. 2005.PubMed/NCBI

12 

Kupfer DM, White VL, Jenkins MC and Burian D: Examining smoking-induced differential gene expression changes in buccal mucosa. BMC Med Genomics. 3:242010. View Article : Google Scholar : PubMed/NCBI

13 

Boyle JO, Gumus ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, Subbaramaiah K and Dannenberg AJ: Effects of cigarette smoke on the human oral mucosal transcriptome. Cancer Prev Res. 3:266–278. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Garzon R, Calin GA and Croce CM: MicroRNAs in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar

15 

Bishop JA, Benjamin H, Cholakh H, Chajut A, Clark DP and Westra WH: Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. Clin Cancer Res. 16:610–619. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Patnaik SK, Kannisto E, Knudsen S and Yendamuri S: Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection. Cancer Res. 70:36–45. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Raponi M, Dossey L, Jatkoe T, Wu X, Chen G, Fan H and Beer DG: MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res. 69:5776–5783. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Momi N, Kaur S, Rachagani S, Ganti AK and Batra SK: Smoking and microRNA dysregulation: a cancerous combination. Trends Mol Med. 20:36–47. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Leidinger P, Keller A and Meese E: MicroRNAs - important molecules in lung cancer research. Front Genet. 2:1042012. View Article : Google Scholar

20 

North CM and Christiani DC: Women and lung cancer: what is new? Semin Thorac Cardiovasc Surg. 25:87–94. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Steiling K, Ryan J, Brody JS and Spira A: The field of tissue injury in the lung and airway. Cancer Prev Res. 1:396–403. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Benner SE, Lippman SM and Hong WK: Current status of retinoid chemoprevention of lung cancer. Oncology. 9:205–216. 1995.PubMed/NCBI

23 

Braakhuis BJ, Brakenhoff RH and Leemans CR: Second field tumors: a new opportunity for cancer prevention? Oncologist. 10:493–500. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Wiencke JK and Kelsey KT: Teen smoking, field cancerization, and a ‘critical period’ hypothesis for lung cancer susceptibility. Environ Health Perspect. 110:555–558. 2002.

25 

Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM and Miller YE: Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J Clin Invest. 100:2133–2137. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH and Spira A: Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2:26ra252010.PubMed/NCBI

27 

Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, Palma J and Brody JS: Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA. 101:10143–10148. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME and Spira A: Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 8:R2012007. View Article : Google Scholar : PubMed/NCBI

29 

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME and Brody JS: Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 13:361–366. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Blomquist T, Crawford EL, Mullins D, Yoon Y, Hernandez DA, Khuder S, Ruppel PL, Peters E, Oldfield DJ, Austermiller B, Anders JC and Willey JC: Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis. Cancer Res. 69:8629–8635. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Spafford MF, Koch WM, Reed AL, Califano JA, Xu LH, Eisenberger CF, Yip L, Leong PL, Wu L, Liu SX, Jeronimo C, Westra WH and Sidransky D: Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis. Clin Cancer Res. 7:607–612. 2001.PubMed/NCBI

32 

Zhang X, Sebastiani P, Liu G, Schembri F, Dumas YM, Langer EM, Alekseyev Y, O’Connor GT, Brooks DR, Lenburg ME and Spira A: Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 41:1–8. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Jung M, Schaefer A, Steiner I, Kempkensteffen C, Stephan C, Erbersdobler A and Jung K: Robust microRNA stability in degraded RNA preparations from human tissue and cell samples. Clin Chem. 56:998–1006. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Damania D, Roy HK, Kunte D, Hurteau JA, Subramanian H, Cherkezyan L, Krosnjar N, Shah M and Backman V: Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells. Int J Cancer. 133:1143–1152. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kunte DP, DelaCruz M, Wali RK, Menon A, Du H, Stypula Y, Patel A, Backman V and Roy HK: Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening. PLoS One. 7:e455912012. View Article : Google Scholar : PubMed/NCBI

36 

Markou A, Liang Y and Lianidou E: Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer. Clin Chem Lab Med. 49:1591–1603. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Chen X, Hu Z, Wang W, Ba Y, Ma L, Zhang C, Wang C, Ren Z, Zhao Y, Wu S, Zhuang R, Zhang Y, Hu H, Liu C, Xu L, Wang J, Shen H, Zhang J, Zen K and Zhang CY: Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer. 130:1620–1628. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Brothers JF, Hijazi K, Mascaux C, El-Zein RA, Spitz MR and Spira A: Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. BMC Med. 11:1682013. View Article : Google Scholar : PubMed/NCBI

39 

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME and Spira A: MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA. 106:2319–2324. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Mascaux C, Laes JF, Anthoine G, Haller A, Ninane V, Burny A and Sculier JP: Evolution of microRNA expression during human bronchial squamous carcinogenesis. Eur Respir J. 33:352–359. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Guan P, Yin Z, Li X, Wu W and Zhou B: Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res. 31:542012. View Article : Google Scholar : PubMed/NCBI

42 

Liu CG, Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Zupo S, Dono M, Alder H, Bullrich F, Negrini M and Croce CM: An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA. 101:9740–9744. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Henschke CI, Yip R and Miettinen OS: Women’s susceptibility to tobacco carcinogens and survival after diagnosis of lung cancer. JAMA. 296:180–184. 2006.

44 

Bell DW, Brannigan BW, Matsuo K, Finkelstein DM, Sordella R, Settleman J, Mitsudomi T and Haber DA: Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Clin Cancer Res. 14:4079–4084. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Wisnivesky JP and Halm EA: Sex differences in lung cancer survival: do tumors behave differently in elderly women? J Clin Oncol. 25:1705–1712. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Chiu HM, Lin JT, Chen TH, Lee YC, Chiu YH, Liang JT, Shun CT and Wu MS: Elevation of C-reactive protein level is associated with synchronous and advanced colorectal neoplasm in men. Am J Gastroenterol. 103:2317–2325. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Tiwari AK, Crawford SE, Radosevich A, Wali RK, Stypula Y, Kunte DP, Mutyal N, Ruderman S, Gomes A, Cornwell ML, De La Cruz M, Brasky J, Gibson TP, Backman V and Roy HK: Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. Cancer Lett. 306:205–213. 2011. View Article : Google Scholar

48 

Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D, Paster BJ, Joshipura K and Wong DT: Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 61:582–588. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Flak MB, Neves JF and Blumberg RS: Immunology. Welcome to the microgenderome. Science. 339:1044–1045. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Roy HK, Subramanian H, Damania D, Hensing TA, Rom WN, Pass HI, Ray D, Rogers JD, Bogojevic A, Shah M, Kuzniar T, Pradhan P and Backman V: Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening. Cancer Res. 70:7748–7754. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M and Spira A: Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res. 4:803–817. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Charlot M, et al: Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications. Int J Oncol 45: 1209-1215, 2014.
APA
Wali, R.K., Hensing, T.A., Ray, D.W., Dela Cruz, M., Tiwari, A.K., Radosevich, A. ... Roy, H.K. (2014). Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications. International Journal of Oncology, 45, 1209-1215. https://doi.org/10.3892/ijo.2014.2495
MLA
Wali, R. K., Hensing, T. A., Ray, D. W., Dela Cruz, M., Tiwari, A. K., Radosevich, A., Jepeal, L., Fernando, H. C., Litle, V. R., Charlot, M., Momi, N., Backman, V., Roy, H. K."Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications". International Journal of Oncology 45.3 (2014): 1209-1215.
Chicago
Wali, R. K., Hensing, T. A., Ray, D. W., Dela Cruz, M., Tiwari, A. K., Radosevich, A., Jepeal, L., Fernando, H. C., Litle, V. R., Charlot, M., Momi, N., Backman, V., Roy, H. K."Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications". International Journal of Oncology 45, no. 3 (2014): 1209-1215. https://doi.org/10.3892/ijo.2014.2495
Copy and paste a formatted citation
x
Spandidos Publications style
Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Charlot M, et al: Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications. Int J Oncol 45: 1209-1215, 2014.
APA
Wali, R.K., Hensing, T.A., Ray, D.W., Dela Cruz, M., Tiwari, A.K., Radosevich, A. ... Roy, H.K. (2014). Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications. International Journal of Oncology, 45, 1209-1215. https://doi.org/10.3892/ijo.2014.2495
MLA
Wali, R. K., Hensing, T. A., Ray, D. W., Dela Cruz, M., Tiwari, A. K., Radosevich, A., Jepeal, L., Fernando, H. C., Litle, V. R., Charlot, M., Momi, N., Backman, V., Roy, H. K."Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications". International Journal of Oncology 45.3 (2014): 1209-1215.
Chicago
Wali, R. K., Hensing, T. A., Ray, D. W., Dela Cruz, M., Tiwari, A. K., Radosevich, A., Jepeal, L., Fernando, H. C., Litle, V. R., Charlot, M., Momi, N., Backman, V., Roy, H. K."Buccal microRNA dysregulation in lung field carcinogenesis: Gender-specific implications". International Journal of Oncology 45, no. 3 (2014): 1209-1215. https://doi.org/10.3892/ijo.2014.2495
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