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Article

Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression

Corrigendum in: /ijo/46/4/1858
  • Authors:
    • Satoko Uraki
    • Kazushi Sugimoto
    • Katsuya Shiraki
    • Masahiko Tameda
    • Yuji Inagaki
    • Suguru Ogura
    • Chika Kasai
    • Keiichiro Nojiri
    • Misao Yoneda
    • Norihiko Yamamoto
    • Yoshiyuki Takei
    • Tsutomu Nobori
    • Masaaki Ito
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan, Department of Gastroenterology, Mie University School of Medicine, Tsu, Japan, Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Tsu, Japan
  • Pages: 1059-1064
    |
    Published online on: June 20, 2014
       https://doi.org/10.3892/ijo.2014.2507
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Abstract

The innate immune system plays an important role as the first line of defense against many types of microbes. Accumulating reports suggest that human β-defensins (hBDs) are expressed by and have certain roles in some cancer cells. In this study, we investigated the roles of hBD-3 in colon cancer cells. The expression of hBD-3 was examined by reverse transcriptase-polymerase chain reaction analysis of colon cancer cell lines and immunohistochemical staining of colon cancer tissues. The effect of hBD-3 on proliferation of colon cancer was assessed using the MTT assay and a real‑time cell analyzer, and the effect of hBD-3 on the migration of colon cancer cells was also examined. The results showed that hBD-3 is not expressed in colon cancer cells but is produced by tumor-infiltrating monocytes. Migration of colon cancer cells was significantly inhibited by hBD-3 in a dose-dependent manner, although proliferation of colon cancer cells was not affected by administration of hBD-3. Moreover, reduced expression of metastasis-associated 1 family, member 2 (MTA2) mRNA in colon cancer cells was associated with exposure to hBD-3. In conclusion, progression of colon cancer was inhibited by hBD-3 in a paracrine fashion. Therefore, hBD-3 may be a potent new agent for treating colon cancer.
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1 

Raj PA and Dentino AR: Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett. 206:9–18. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Ganz T: Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 3:710–720. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Yang D, Biragyn A, Hoover DM, Lubkowski J and Oppenheim JJ: Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol. 22:181–215. 2004. View Article : Google Scholar

4 

Schutte BC, Mitros JP, Bartlett JA, et al: Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA. 99:2129–2133. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Jia HP, Schutte BC, Schudy A, et al: Discovery of new human beta-defensins using a genomics-based approach. Gene. 263:211–218. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Sorensen OE, Thapa DR, Rosenthal A, Liu L, Roberts AA and Ganz T: Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol. 174:4870–4879. 2005. View Article : Google Scholar

7 

Zlotnik A and Yoshie O: Chemokines: a new classification system and their role in immunity. Immunity. 12:121–127. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Wu Z, Hoover DM, Yang D, et al: Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci USA. 100:8880–8885. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Shestakova T, Zhuravel E, Bolgova L, Alekseenko O, Soldatkina M and Pogrebnoy P: Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study. Exp Oncol. 30:153–156. 2008.PubMed/NCBI

10 

Shestakova T, Zhuravel E, Bolgova L, et al: Immunohistochemical analysis of beta-defensin-2 expression in human lung tumors. Exp Oncol. 32:273–276. 2010.PubMed/NCBI

11 

Arimura Y, Ashitani J, Yanagi S, et al: Elevated serum beta-defensins concentrations in patients with lung cancer. Anticancer Res. 24:4051–4057. 2004.PubMed/NCBI

12 

Markeeva N, Lisovskiy I, Lyzogubov V, et al: Expression of beta-defensin-2 in human gastric tumors: a pilot study. Exp Oncol. 27:130–135. 2005.PubMed/NCBI

13 

Markeeva N, Lysovskiy I, Zhuravel E, et al: Involvement of human beta-defensin-2 in proliferation of transformed cells of human cervix. Exp Oncol. 27:308–313. 2005.PubMed/NCBI

14 

Mburu YK, Abe K, Ferris LK, Sarkar SN and Ferris RL: Human beta-defensin 3 promotes NF-kappaB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck. Carcinogenesis. 32:168–174. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Melle C, Ernst G, Schimmel B, et al: Discovery and identification of alpha-defensins as low abundant, tumor-derived serum markers in colorectal cancer. Gastroenterology. 129:66–73. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Albrethsen J, Bogebo R, Gammeltoft S, Olsen J, Winther B and Raskov H: Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1–3) in colon cancer serum and tumours: a biomarker study. BMC Cancer. 5:82005.

17 

Albrethsen J, Moller CH, Olsen J, Raskov H and Gammeltoft S: Human neutrophil peptides 1, 2 and 3 are biochemical markers for metastatic colorectal cancer. Eur J Cancer. 42:3057–3064. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Wang K, Wang JH, Baskaran H, Wang R and Jurevic R: Effect of human beta-defensin-3 on head and neck cancer cell migration using micro-fabricated cell islands. Head Neck Oncol. 4:412012. View Article : Google Scholar : PubMed/NCBI

19 

Kawsar HI, Weinberg A, Hirsch SA, et al: Overexpression of human beta-defensin-3 in oral dysplasia: potential role in macrophage trafficking. Oral Oncol. 45:696–702. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Winter J, Pantelis A, Reich R, et al: Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation. Cancer Invest. 29:196–201. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Harder J, Bartels J, Christophers E and Schroder JM: Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem. 276:5707–5713. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Kawauchi K, Yagihashi A, Tsuji N, et al: Human beta-defensin-3 induction in H. pylori-infected gastric mucosal tissues. World J Gastroenterol. 12:5793–5797. 2006.PubMed/NCBI

23 

Fahlgren A, Hammarstrom S, Danielsson A and Hammarstrom ML: beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol. 137:379–385. 2004. View Article : Google Scholar

24 

Donald CD, Sun CQ, Lim SD, et al: Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Lab Invest. 83:501–505. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Young AN, de Oliveira Salles PG, Lim SD, et al: Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumors derived from gene expression profiling studies using cDNA microarrays. Am J Surg Pathol. 27:199–205. 2003. View Article : Google Scholar

26 

Bullard RS, Gibson W, Bose SK, et al: Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Mol Immunol. 45:839–848. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Joly S, Compton LM, Pujol C, Kurago ZB and Guthmiller JM: Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma. Oral Microbiol Immunol. 24:353–360. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Yoshimoto T, Yamaai T, Mizukawa N, et al: Different expression patterns of beta-defensins in human squamous cell carcinomas. Anticancer Res. 23:4629–4633. 2003.PubMed/NCBI

29 

Shuyi Y, Feng W, Jing T, et al: Human beta-defensin-3 (hBD-3) upregulated by LPS via epidermal growth factor receptor (EGFR) signaling pathways to enhance lymphatic invasion of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 112:616–625. 2011. View Article : Google Scholar

30 

Xu N, Wang YS, Pan WB, et al: Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice. Mol Cancer Ther. 7:1588–1597. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Toh Y, Oki E, Oda S, et al: Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis. Int J Cancer. 74:459–463. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Martin MD, Fischbach K, Osborne CK, Mohsin SK, Allred DC and O’Connell P: Loss of heterozygosity events impeding breast cancer metastasis contain the MTA1 gene. Cancer Res. 61:3578–3580. 2001.PubMed/NCBI

33 

Hamatsu T, Rikimaru T, Yamashita Y, et al: The role of MTA1 gene expression in human hepatocellular carcinoma. Oncol Rep. 10:599–604. 2003.PubMed/NCBI

34 

Sasaki H, Moriyama S, Nakashima Y, et al: Expression of the MTA1 mRNA in advanced lung cancer. Lung Cancer. 35:149–154. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A and Reinberg D: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13:1924–1935. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Toh Y and Nicolson GL: The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clin Exp Metastasis. 26:215–227. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Ji Y, Zhang P, Lu Y and Ma D: Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication. J Huazhong Univ Sci Technolog Med Sci. 26:359–362. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Lee H, Ryu SH, Hong SS, et al: Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. J Gastroenterol Hepatol. 24:1445–1450. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Liu SL, Han Y, Zhang Y, et al: Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer. Target Oncol. 7:135–143. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Covington KR, Brusco L, Barone I, et al: Metastasis tumor-associated protein 2 enhances metastatic behavior and is associated with poor outcomes in estrogen receptor-negative breast cancer. Breast Cancer Res Treat. 141:375–384. 2013. View Article : Google Scholar

41 

Zhou C, Ji J, Cai Q, et al: MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1. Mol Cancer. 12:1022013. View Article : Google Scholar : PubMed/NCBI

42 

Cui Y, Niu A, Pestell R, et al: Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol. 20:2020–2035. 2006. View Article : Google Scholar

43 

Luo J, Su F, Chen D, Shiloh A and Gu W: Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature. 408:377–381. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Uraki S, Sugimoto K, Shiraki K, Tameda M, Inagaki Y, Ogura S, Kasai C, Nojiri K, Yoneda M, Yamamoto N, Yamamoto N, et al: Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858. Int J Oncol 45: 1059-1064, 2014.
APA
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S. ... Ito, M. (2014). Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858. International Journal of Oncology, 45, 1059-1064. https://doi.org/10.3892/ijo.2014.2507
MLA
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S., Kasai, C., Nojiri, K., Yoneda, M., Yamamoto, N., Takei, Y., Nobori, T., Ito, M."Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858". International Journal of Oncology 45.3 (2014): 1059-1064.
Chicago
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S., Kasai, C., Nojiri, K., Yoneda, M., Yamamoto, N., Takei, Y., Nobori, T., Ito, M."Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858". International Journal of Oncology 45, no. 3 (2014): 1059-1064. https://doi.org/10.3892/ijo.2014.2507
Copy and paste a formatted citation
x
Spandidos Publications style
Uraki S, Sugimoto K, Shiraki K, Tameda M, Inagaki Y, Ogura S, Kasai C, Nojiri K, Yoneda M, Yamamoto N, Yamamoto N, et al: Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858. Int J Oncol 45: 1059-1064, 2014.
APA
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S. ... Ito, M. (2014). Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858. International Journal of Oncology, 45, 1059-1064. https://doi.org/10.3892/ijo.2014.2507
MLA
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S., Kasai, C., Nojiri, K., Yoneda, M., Yamamoto, N., Takei, Y., Nobori, T., Ito, M."Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858". International Journal of Oncology 45.3 (2014): 1059-1064.
Chicago
Uraki, S., Sugimoto, K., Shiraki, K., Tameda, M., Inagaki, Y., Ogura, S., Kasai, C., Nojiri, K., Yoneda, M., Yamamoto, N., Takei, Y., Nobori, T., Ito, M."Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression Corrigendum in /ijo/46/4/1858". International Journal of Oncology 45, no. 3 (2014): 1059-1064. https://doi.org/10.3892/ijo.2014.2507
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