Open Access

Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells

  • Authors:
    • Su-Jin Park
    • Jina Ryu
    • In-Hye Kim
    • Youn-Hee Choi
    • Taek-Jeong Nam
  • View Affiliations

  • Published online on: June 20, 2014     https://doi.org/10.3892/ijo.2014.2509
  • Pages: 1011-1016
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

This study examined how PPY, a peptide from Porphyra yezoensis, regulates multiple cell growth-related signaling pathways in MCF-7 cells. This study determined that PPY induces cell cycle arrest and inhibits the IGF-IR signaling pathway. Cell proliferation studies revealed that PPY induced cell death in a dose-dependent manner. Expression levels of IGF-IR were decreased in MCF-7 cells by PPY in a dose‑dependent manner. These results indicate that inhibition of the IGF-IR pathway is also involved in PPY induced proliferation of MCF-7 cells. In addition, these data demonstrated that PPY induces cell cycle arrest and activates apoptosis.
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September-2014
Volume 45 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Park S, Ryu J, Kim I, Choi Y and Nam T: Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells. Int J Oncol 45: 1011-1016, 2014
APA
Park, S., Ryu, J., Kim, I., Choi, Y., & Nam, T. (2014). Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells. International Journal of Oncology, 45, 1011-1016. https://doi.org/10.3892/ijo.2014.2509
MLA
Park, S., Ryu, J., Kim, I., Choi, Y., Nam, T."Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells". International Journal of Oncology 45.3 (2014): 1011-1016.
Chicago
Park, S., Ryu, J., Kim, I., Choi, Y., Nam, T."Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells". International Journal of Oncology 45, no. 3 (2014): 1011-1016. https://doi.org/10.3892/ijo.2014.2509