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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2014 Volume 45 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2014 Volume 45 Issue 4

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Article

Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors

  • Authors:
    • Lei Cao
    • Ping Wang
    • Hui Luo
    • Xi-Rui Wang
    • Xie-Feng Wang
    • Jun-Xia Zhang
    • Ying-Yi Wang
    • Lei Yao
    • Ning Liu
    • Yong-Ping You

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China, Liver Transplantation Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 1609-1617
    |
    Published online on: July 3, 2014
       https://doi.org/10.3892/ijo.2014.2532
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Abstract

Cancer cells may involve diverse mutations, but they often rely on continued expression of a single oncoprotein for survival, as a response to targeting this protein. Generally, Ras is overexpressed in human epithelial tumors and cancellation of activated Ras inhibits carcinoma cell proliferation and differentiation ability, and induces apoptotosis of tumor cells. However, the mechanisms of inhibition of activated Ras that suppress the malignancy activity of human epithelial tumors remain to be illuminated. We utilized text-mining of MEDLINE abstracts with natural language processing to establish the Ras biologic association network, and identified several interactions of this network with the Ras pathway. Our investigation not only examined the expression of Ras and Hub genes (PIK3CA, MDM2, CCND1, EGFR, JUN, MYC, VEGFA, ERK1 and ERK2) but also confirmed inhibition of activated Ras reduced expression of multiple oncogene in vitro studies. Our studies provide strong support for the conclusion that cancellation of activated Ras specifically regulates defective Ras pathways in human tumor cells.

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Copy and paste a formatted citation
Spandidos Publications style
Cao L, Wang P, Luo H, Wang X, Wang X, Zhang J, Wang Y, Yao L, Liu N, You Y, You Y, et al: Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors. Int J Oncol 45: 1609-1617, 2014.
APA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J. ... You, Y. (2014). Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors. International Journal of Oncology, 45, 1609-1617. https://doi.org/10.3892/ijo.2014.2532
MLA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45.4 (2014): 1609-1617.
Chicago
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45, no. 4 (2014): 1609-1617. https://doi.org/10.3892/ijo.2014.2532
Copy and paste a formatted citation
x
Spandidos Publications style
Cao L, Wang P, Luo H, Wang X, Wang X, Zhang J, Wang Y, Yao L, Liu N, You Y, You Y, et al: Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors. Int J Oncol 45: 1609-1617, 2014.
APA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J. ... You, Y. (2014). Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors. International Journal of Oncology, 45, 1609-1617. https://doi.org/10.3892/ijo.2014.2532
MLA
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45.4 (2014): 1609-1617.
Chicago
Cao, L., Wang, P., Luo, H., Wang, X., Wang, X., Zhang, J., Wang, Y., Yao, L., Liu, N., You, Y."Inhibition of activated Ras suppresses multiple oncogenic Hub genes in human epithelial tumors". International Journal of Oncology 45, no. 4 (2014): 1609-1617. https://doi.org/10.3892/ijo.2014.2532
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