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Article

Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells

  • Authors:
    • Soma Kundu
    • Tae Hyung Kim
    • Jung Hyun Yoon
    • Han-Seung Shin
    • Jaewon Lee
    • Jee H. Jung
    • Hyung Sik Kim
  • View Affiliations / Copyright

    Affiliations: Laboratory of Marine Natural Product, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea, Laboratory of Molecular Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea, Department of Food Science and Biotechnology, Dongguk University-Seoul, Seoul 100-715, Republic of Korea
  • Pages: 2331-2340
    |
    Published online on: September 17, 2014
       https://doi.org/10.3892/ijo.2014.2659
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Abstract

Microtubule targeting chemicals are considered excellent antitumor drugs through their binding to tubulin, which affects the instability of microtubules resulting in arrest of cancer cells. The present study was designed to investigate the antitumor effects of viriditoxin (VDT) against human prostate cancer cells. VDT, isolated from Paecilomyces variotii fungus, which was derived from the jellyfish Nemopilema nomurai, offers a new approach for controlling resistant bacterial infections by blocking bacterial cell division proteins. VDT produced dose-dependent cytotoxicity against human prostate cancer cells. Treatment with VDT promoted both apoptosis and autophagy in LNCaP cells. Annexin V/FITC staining indicated that apoptosis occurred in VDT-treated LNCaP cells. DAPI staining revealed morphological changes in the cell nuclei indicative of mitotic catastrophe in LNCaP cells. VDT caused cell growth inhibition via G2/M phase arrest. Moreover, VDT also increased autophagic cell death in LNCaP cells by induction of several autophagy-related proteins such as LC3  II, Atg5, Atg7 and beclin-1 protein, which are essential for autophagy induction. These results were also confirmed by acridine orange staining. This study indicates that VDT could potentially be effective against prostate cancer by promoting multiple modes of growth arrest and cell death coupled with apoptosis and autophagy.
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1 

Jemal A, Bray F, Center MM, Ferly J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 6:69–90. 2011. View Article : Google Scholar

2 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 6:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Riihimäki M, Thomsen H, Brandt A, Sundquist J and Hemminki K: What do prostate cancer patients die of? Oncologist. 16:175–181. 2011.PubMed/NCBI

4 

Hsing AW and Chokkalingam AP: Prostate cancer epidemiology. Front Biosci. 11:1388–1413. 2006. View Article : Google Scholar

5 

Parent ME and Siemiatycki J: Occupation and prostate cancer. Epidemiol Rev. 23:138–143. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Lock RL and Harry EJ: Cell-division inhibitors: new insights for future antibiotics. Nat Rev Drug Discov. 7:324–338. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Erickson HP, Anderson DE and Osawa M: FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. Microbiol Mol Biol Rev. 74:504–528. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, Gonzalez A, Cully D, Bramhill D and Singh S: Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem. 278:44424–44428. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Löwe J and Amos LA: Crystal structure of the bacterial cell-division protein FtsZ. Nature. 391:203–206. 1998.

10 

Chung KS, Yim NH, Lee SH, Choi SJ, Hur KS, Hoe KL, Kim DU, Goehle S, Kim HB, Song KB, Yoo HS, Bae KH, Simon J and Won M: Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants. Invest New Drugs. 26:299–307. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Heggeness MH, Simon M and Singer SJ: Association of mitochondria with microtubules in cultured cells. Proc Natl Acad Sci. 75:3863–3866. 1978. View Article : Google Scholar : PubMed/NCBI

12 

Diaz JF and Andreu JM: Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry. 32:2747–2755. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Lavelle F, Bissery MC, Combeau C, Riou JF, Vrignaud P and André S: Preclinical evaluation of docetaxel (Taxotere). Semin Oncol. 22:3–16. 1995.

14 

Stein CA: Mechanisms of action of taxanes in prostate cancer. Semin Oncol. 26:3–7. 1999.PubMed/NCBI

15 

Kim JY, Chung JY, Lee SG, Kim YJ, Park JE, Yun J, Park YC, Kim BG, Yoo YH and Kim JM: p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. Int J Mol Med. 31:1388–1394. 2013.PubMed/NCBI

16 

Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG and Youle RJ: Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol. 139:1281–1292. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Saunders DE, Lawrence WD, Christensen C, Wappler NL, Ruan H and Deppe G: Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells. Int J Cancer. 70:214–220. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Lin HL, Liu TY, Chau GY, Lui WY and Chi CW: Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer. 89:983–994. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Vakifahmetoglu H, Olsson M and Zhivotovsky B: Death through a tragedy: mitotic catastrophe. Cell Death Differ. 15:1153–1162. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Roninson IB, Broude EV and Chang BD: If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 4:303–313. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Alotaibi MR, Asnake B, Di X, Beckman MJ, Durrant D, Simoni D, Baruchello R, Lee RM, Schwartz EL and Gewirtz DA: Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. Biochem Pharmacol. 86:1688–1698. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Aplin A, Jasionowski T, Tuttle DL, Lenk SE and Dunn WA Jr: Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles. J Cell Physiol. 152:458–466. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Fass E, Shvets E, Degani I, Hirschberg K and Elazar Z: Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J Biol Chem. 281:36303–36316. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Kochl R, Hu XW, Chan EY and Tooze SA: Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic. 7:129–145. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Acharya BR, Bhattacharyya S, Choudhury D and Chakrabarti G: The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis. 16:924–939. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Xie R, Nguyen S, McKeehan WL and Liu L: Acetylated microtubules are required for fusion of autophagosomes with lysosomes. BMC Cell Biol. 11:89–100. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Mansila S, Bataller M and Portugal J: Mitotic catastrophe as a consequence of chemotherapy. Anticancer Agents Med Chem. 6:589–602. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805–816. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Grimmler M, Wang Y, Mund T, Ciliensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW and Hengst L: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 128:269–280. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Millot C, Millot JM, Morjani H, Desplaces A and Manfait M: Characterization of acidic vesicles in multidrug-resistant and sensitive cancer cells by acridine orange staining and confocal micro spectrofluorometry. J Histochem Cytochem. 45:1255–1264. 1997. View Article : Google Scholar

31 

Perez EA: Microtubule inhibitors: differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol Cancer Ther. 8:2086–2095. 2009. View Article : Google Scholar

32 

Lu Y, Chen J, Xiao M, Li W and Miller DD: An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res. 29:2943–2971. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Longuet M, Serduc R and Riva C: Implication of bax in apoptosis depends on microtubule network mobility. Int J Oncol. 25:309–317. 2004.PubMed/NCBI

34 

Botta M, Forli S, Magnani M and Manetti F: Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 286:279–328. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Georgiadis MS, Russell EK, Gazdar AF and Johnson BE: Paclitaxel cytotoxicity against human lung cancer cell lines increases with prolonged exposure durations. Clin Cancer Res. 3:449–454. 1997.PubMed/NCBI

36 

Checchi PM, Nettles JH, Zhou J, Snyder JP and Joshi HC: Microtubule-interacting drugs for cancer treatment. Trends Pharmacol Sci. 24:361–365. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Hernandez-Vargas H, Palacios J and Moreno-Bueno G: Molecular profiling of docetaxel cytotoxicity in breast cancer cells: uncoupling of aberrant mitosis and apoptosis. Oncogene. 26:2902–2913. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Silva MRO, Kawai K, Hosoe T, Takaki GMC, Gusmão NB and Fukushima K: Viriditoxin, an antibacterial substance produced by mangrove endophytic fungus Paecilomyces variotii. Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education. Méndez-Vilas A: Formatex Research Center; Badajoz: pp. 1406–1411. 2013

39 

Park YS, Grove CI, González-López M, Urgaonkar S, Fettinger JC and Shaw JT: Synthesis of (−)-viriditoxin: a 6,6′-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ. Angew Chem Int Ed Engl. 50:3730–3733. 2011.

40 

Feng Z, Zhang H, Levine AJ and Jin S: The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci. 102:8204–8209. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Brady CA and Attardi LD: p53 at a glance. J Cell Sci. 123:2527–2532. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Eastman A: Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J Cell Biochem. 91:223–231. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Payne SR, Zhang S, Tsuchiya K, Moser R, Gurley KE, Longton G, deBoer J and Kemp CJ: p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. Mol Cell Biol. 28:258–268. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA and Kroemer G: Autophagy regulation by p53. Curr Opin Cell Biol. 22:181–185. 2010. View Article : Google Scholar

45 

Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D’Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F and Kroemer G: Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 10:676–687. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G and Distler JH: Autophagy regulates TNFα-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 72:761–768. 2013.

47 

Klionsky DJ: The molecular machinery of autophagy: unanswered questions. J Cell Sci. 118:7–18. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Klionsky DJ: Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 8:931–937. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Mizushima N and Klionsky DJ: Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr. 27:19–40. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Shimizu S, Yoshida T, Tsujioka M and Arakawa S: Autophagic cell death and cancer. Int J Mol Sci. 15:3145–3153. 2014. View Article : Google Scholar

51 

Nabha SM, Mohammad RM, Dandashi MH, Coupaye-Gerard B, Aboukameel A, Pettit GR and Al-Katib AM: Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly (adp-ribose) polymerase cleavage. Clin Cancer Res. 8:2735–2741. 2002.PubMed/NCBI

52 

Burns TF, Fei P, Scata KA, Dicker DT and El-Deiry WS: Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol. 23:5556–5571. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Chen Y, McMillan-Ward E, Kong J, Israels SJ and Gibson SB: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 15:171–182. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Kamath K, Okouneva T, Larson G, Panda D, Wilson L and Jordan MA: 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther. 5:2225–2233. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Lorin S, Borges A, Ribeiro Dos Santos L, Souquere S, Pierron G, Ryan KM, Codogno P and Djavaheri-Mergny M: c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res. 69:6924–6931. 2009. View Article : Google Scholar

56 

Arstila AU, Nuuja IJ and Trump BF: Studies on cellular autophagocytosis: vinblastine-induced autophagy in the rat liver. Exp Cell Res. 87:249–252. 1974. View Article : Google Scholar : PubMed/NCBI

57 

Marzella L, Sandberg PO and Glaumann H: Autophagic degradation in rat liver after vinblastine treatment. Exp Cell Res. 128:291–301. 1980. View Article : Google Scholar : PubMed/NCBI

58 

Tanida I, Ueno T and Kominami E: LC3 and autophagy. Methods Mol Biol. 445:77–88. 2008. View Article : Google Scholar

59 

Geeraert C, Ratier A, Pfisterer SG, Perdiz D, Cantaloube I, Rouault A, Pattingre S, Proikas-Cezanne T, Codogno P and Pous C: Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J Biol Chem. 285:24184–24194. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Shen S, Kepp O, Martins I, Vitale I, Souquère S, Castedo M, Pierron G and Kroemer G: Defective autophagy associated with LC3 puncta in epothilone-resistant cancer cells. Cell Cycle. 9:377–383. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Reunanen H, Marttinen M and Hirsimaki P: Effects of griseofulvin and nocodazole on the accumulation of autophagic vacuoles in Ehrlich ascites tumor cells. Exp Mol Pathol. 48:97–102. 1988. View Article : Google Scholar : PubMed/NCBI

62 

Mackeh R, Perdiz D, Lorin S, Codogno P and Pous C: Autophagy and microtubules - new story, old players. J Cell Sci. 126:1071–1080. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kundu S, Kim TH, Yoon JH, Shin H, Lee J, Jung JH and Kim HS: Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. Int J Oncol 45: 2331-2340, 2014.
APA
Kundu, S., Kim, T.H., Yoon, J.H., Shin, H., Lee, J., Jung, J.H., & Kim, H.S. (2014). Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. International Journal of Oncology, 45, 2331-2340. https://doi.org/10.3892/ijo.2014.2659
MLA
Kundu, S., Kim, T. H., Yoon, J. H., Shin, H., Lee, J., Jung, J. H., Kim, H. S."Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells". International Journal of Oncology 45.6 (2014): 2331-2340.
Chicago
Kundu, S., Kim, T. H., Yoon, J. H., Shin, H., Lee, J., Jung, J. H., Kim, H. S."Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells". International Journal of Oncology 45, no. 6 (2014): 2331-2340. https://doi.org/10.3892/ijo.2014.2659
Copy and paste a formatted citation
x
Spandidos Publications style
Kundu S, Kim TH, Yoon JH, Shin H, Lee J, Jung JH and Kim HS: Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. Int J Oncol 45: 2331-2340, 2014.
APA
Kundu, S., Kim, T.H., Yoon, J.H., Shin, H., Lee, J., Jung, J.H., & Kim, H.S. (2014). Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. International Journal of Oncology, 45, 2331-2340. https://doi.org/10.3892/ijo.2014.2659
MLA
Kundu, S., Kim, T. H., Yoon, J. H., Shin, H., Lee, J., Jung, J. H., Kim, H. S."Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells". International Journal of Oncology 45.6 (2014): 2331-2340.
Chicago
Kundu, S., Kim, T. H., Yoon, J. H., Shin, H., Lee, J., Jung, J. H., Kim, H. S."Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells". International Journal of Oncology 45, no. 6 (2014): 2331-2340. https://doi.org/10.3892/ijo.2014.2659
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