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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December-2014 Volume 45 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Review

Significance of AKT in gastric cancer (Review)

  • Authors:
    • Takamitsu Sasaki
    • Hiroki Kuniyasu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan‑ku, Fukuoka 814‑0180, Japan, Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan
  • Pages: 2187-2192
    |
    Published online on: September 26, 2014
       https://doi.org/10.3892/ijo.2014.2678
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Abstract

AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro‑proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular‑targeted agents. When analyzing the role of AKT in cancer cells, it is important to consider the microenvironment and variations of cancers. In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, along with an in‑depth discussion of its role in gastric cancer and its potential as a target for therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaki T and Kuniyasu H: Significance of AKT in gastric cancer (Review). Int J Oncol 45: 2187-2192, 2014.
APA
Sasaki, T., & Kuniyasu, H. (2014). Significance of AKT in gastric cancer (Review). International Journal of Oncology, 45, 2187-2192. https://doi.org/10.3892/ijo.2014.2678
MLA
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45.6 (2014): 2187-2192.
Chicago
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45, no. 6 (2014): 2187-2192. https://doi.org/10.3892/ijo.2014.2678
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki T and Kuniyasu H: Significance of AKT in gastric cancer (Review). Int J Oncol 45: 2187-2192, 2014.
APA
Sasaki, T., & Kuniyasu, H. (2014). Significance of AKT in gastric cancer (Review). International Journal of Oncology, 45, 2187-2192. https://doi.org/10.3892/ijo.2014.2678
MLA
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45.6 (2014): 2187-2192.
Chicago
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45, no. 6 (2014): 2187-2192. https://doi.org/10.3892/ijo.2014.2678
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