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Article

Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth

Corrigendum in: /10.3892/ijo.2023.5583
  • Authors:
    • Zi-Xue Xuan
    • Lin-Na Li
    • Qi Zhang
    • Cheng-Wang Xu
    • De-Xuan Yang
    • Ye Yuan
    • Ying-Hong An
    • Shan-Shan Wang
    • Xiao-Wen Li
    • Shou-Jun Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, P.R. China, Department of Production Technology, Shandong Buchang Shenzhou Pharmaceutical Co., Ltd., Heze 274000, P.R. China
  • Pages: 2411-2420
    |
    Published online on: October 1, 2014
       https://doi.org/10.3892/ijo.2014.2690
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Abstract

The critical role of VEGFR2 in tumor neovascularization and progression has allowed the design of clinically beneficial therapies based on it. Here we show that BC001, a new fully human anti-VEGFR2 monoclonal antibody, inhibits VEGF-stimulated endothelial cell migration, tube formation, and effectively suppressed the transdifferentiation of cancer stem cells into endothelial cells in vitro. Since BC001 exhibited no activity against the mouse VEGFR2 and mouse based study was required to confirm its efficacy in vivo, BC101, the mouse analogue of BC001, was developed. BC101 significantly attenuated angiogenesis according to Matrigel plug assay and resulted in ~80% growth inhibition of mouse B16F10 homograft tumors relative to vehicle control. Similarly, human analogue BC001 suppressed the growth of human xenograft tumors HCT116 and BGC823. Furthermore, immunohistochemical results showed reduced expression of CD31, VEGFR2 and Ki-67, as well as increased expression of Caspase 3 in BC001-treated tumor, which indicated BC001 was able to significantly decrease microvessel density, suppress proliferation and promote apoptosis. These results demonstrate the fully human VEGFR2 monoclonal antibody BC001 can work as an effective inhibitor of tumor angiogenesis and tumor growth both in vitro and in vivo.
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1 

Folkman J: Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 6:273–286. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Chung AS, Lee J and Ferrara N: Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer. 10:505–514. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Ebos JM and Kerbel RS: Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol. 8:210–221. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wong ML, Prawira A, Kaye AH and Hovens CM: Tumour angiogenesis: its mechanism and therapeutic implications in malignant gliomas. J Clin Neurosci. 16:1119–1130. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Brower V: Tumor angiogenesis - new drugs on the block. Nat Biotechnol. 17:963–968. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Olsson AK, Dimberg A, Kreuger J and Claesson-Welsh L: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 7:359–371. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Teicher BA: Antiangiogenic agents and targets: a perspective. Biochem Pharmacol. 81:6–12. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, et al: Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci USA. 109:2784–2789. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Xu HY, Pan YM, Chen ZW, Lin Y, Wang LH, Chen YH, et al: 12-Deoxyphorbol 13-palmitate inhibit VEGF-induced angiogenesis via suppression of VEGFR-2-signaling pathway. J Ethnopharmacol. 146:724–733. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Liao X, Zhou X, Mak NK and Leung KN: Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway. PLoS One. 8:e822942013. View Article : Google Scholar : PubMed/NCBI

11 

Holzer TR, Fulford AD, Nedderman DM, Umberger TS, Hozak RR, Joshi A, et al: Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung. PLoS One. 8:e802922013. View Article : Google Scholar : PubMed/NCBI

12 

Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ and Brekken RA: GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. BMC Cancer. 10:3972010. View Article : Google Scholar : PubMed/NCBI

13 

Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, et al: Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci USA. 108:4274–4280. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Hutchinson E: Stem cells: tumour stem cells generate vasculature. Nat Rev Cancer. 11:42011. View Article : Google Scholar : PubMed/NCBI

15 

Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, Cenci T, et al: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature. 468:824–828. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, Lee M, et al: Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med. 209:507–520. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, et al: A perivascular niche for brain tumor stem cells. Cancer Cell. 11:69–82. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Saraswati S and Agrawal SS: Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo. Cancer Lett. 332:83–93. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, et al: Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci USA. 110:6530–6535. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, et al: Glioblastoma stem-like cells give rise to tumour endothelium. Nature. 468:829–833. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Pang X, Yi T, Yi Z, Cho SG, Qu W, Pinkaew D, et al: Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res. 69:518–525. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Adini A, Fainaru O, Udagawa T, Connor KM, Folkman J and D’Amato RJ: Matrigel cytometry: a novel method for quantifying angiogenesis in vivo. J Immunol Methods. 342:78–81. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Gao Z, Zheng J, Yang B, Wang Z, Fan H, Lv Y, et al: Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model. Cancer Lett. 335:93–99. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Evellin S, Galvagni F, Zippo A, Neri F, Orlandini M, Incarnato D, et al: FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription. Mol Cell Biol. 33:1198–1209. 2013.PubMed/NCBI

25 

Scully S, Francescone R, Faibish M, Bentley B, Taylor SL, Oh D, et al: Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas. J Neurosci. 32:12950–12960. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, et al: Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 153:139–152. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Dong J, Zhao Y, Huang Q, Fei X, Diao Y, Shen Y, et al: Glioma stem/progenitor cells contribute to neovascularization via transdifferentiation. Stem Cell Rev. 7:141–152. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Ribatti D: Cancer stem cells and tumor angiogenesis. Cancer Lett. 321:13–17. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, et al: Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66:7843–7848. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, et al: Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 4:115ra32012.PubMed/NCBI

31 

Carmeliet P and Jain RK: Molecular mechanisms and clinical applications of angiogenesis. Nature. 473:298–307. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Potente M, Gerhardt H and Carmeliet P: Basic and therapeutic aspects of angiogenesis. Cell. 146:873–887. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ellis LM and Hicklin DJ: VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 8:579–591. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Goel HL and Mercurio AM: VEGF targets the tumour cell. Nat Rev Cancer. 13:871–882. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Chatterjee S, Heukamp LC, Siobal M, Schttle J, Wieczorek C, Peifer M, et al: Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 123:1732–1740. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K and Mittal V: Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 319:195–198. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Huang YH, Yuan JP, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, et al: Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci USA. 109:17561–17566. 2012. View Article : Google Scholar

38 

Spring H, Schuler T, Arnold B, Hammerling GJ and Ganss R: Chemokines direct endothelial progenitors into tumor neovessels. Proc Natl Acad Sci USA. 102:18111–18116. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Narunsky L, Oren R, Bochner F and Neeman M: Imaging aspects of the tumor stroma with therapeutic implications. Pharmacol Ther. 141:192–208. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Tang X: Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer. Cancer Lett. 332:3–10. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xuan Z, Li L, Zhang Q, Xu C, Yang D, Yuan Y, An Y, Wang S, Li X, Yuan S, Yuan S, et al: Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583. Int J Oncol 45: 2411-2420, 2014.
APA
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y. ... Yuan, S. (2014). Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583. International Journal of Oncology, 45, 2411-2420. https://doi.org/10.3892/ijo.2014.2690
MLA
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y., An, Y., Wang, S., Li, X., Yuan, S."Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583". International Journal of Oncology 45.6 (2014): 2411-2420.
Chicago
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y., An, Y., Wang, S., Li, X., Yuan, S."Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583". International Journal of Oncology 45, no. 6 (2014): 2411-2420. https://doi.org/10.3892/ijo.2014.2690
Copy and paste a formatted citation
x
Spandidos Publications style
Xuan Z, Li L, Zhang Q, Xu C, Yang D, Yuan Y, An Y, Wang S, Li X, Yuan S, Yuan S, et al: Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583. Int J Oncol 45: 2411-2420, 2014.
APA
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y. ... Yuan, S. (2014). Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583. International Journal of Oncology, 45, 2411-2420. https://doi.org/10.3892/ijo.2014.2690
MLA
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y., An, Y., Wang, S., Li, X., Yuan, S."Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583". International Journal of Oncology 45.6 (2014): 2411-2420.
Chicago
Xuan, Z., Li, L., Zhang, Q., Xu, C., Yang, D., Yuan, Y., An, Y., Wang, S., Li, X., Yuan, S."Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth Corrigendum in /10.3892/ijo.2023.5583". International Journal of Oncology 45, no. 6 (2014): 2411-2420. https://doi.org/10.3892/ijo.2014.2690
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