Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells

  • Authors:
    • Xiao-Jian Han
    • Zhang-Jian Yang
    • Li-Ping Jiang
    • Yong-Fang Wei
    • Ming-Fang Liao
    • Yisong Qian
    • Yong Li
    • Xuan Huang
    • Jian-Bin Wang
    • Hong-Bo Xin
    • Yu-Ying Wan
  • View Affiliations

  • Published online on: November 27, 2014     https://doi.org/10.3892/ijo.2014.2781
  • Pages: 691-700
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Abstract

Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial fission and migration in metastatic MDA-MB‑231 cells, but not in non-metastatic MCF-7 cells. Inhibition of Drp1-dependent mitochondrial fission by Mdivi-1 or silencing Drp1 attenuated hypoxia-induced mitochondrial fission and migration in MDA-MB‑231 cells. On the other hand, cisplatin induced significant apoptosis and mitochondrial fission in MDA-MB‑231 cells, but not in MCF-7 cells. Mdivi-1 and silencing Drp1 also efficiently prevented cisplatin-induced MMP decrease, ROS production and apoptosis in MDA-MB‑231 cells. Our data suggest that Drp1-dependent mitochondrial fission not only regulates hypoxia-induced migration of breast cancer cells, but also facilitates its sensitivity to chemotherapeutic agents. Thus, targeting Drp1-dependent mitochondrial dynamics may provide a novel strategy to suppress breast cancer metastasis and improve the chemotherapeutic effect in the future.
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February-2015
Volume 46 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Han X, Yang Z, Jiang L, Wei Y, Liao M, Qian Y, Li Y, Huang X, Wang J, Xin H, Xin H, et al: Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol 46: 691-700, 2015
APA
Han, X., Yang, Z., Jiang, L., Wei, Y., Liao, M., Qian, Y. ... Wan, Y. (2015). Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. International Journal of Oncology, 46, 691-700. https://doi.org/10.3892/ijo.2014.2781
MLA
Han, X., Yang, Z., Jiang, L., Wei, Y., Liao, M., Qian, Y., Li, Y., Huang, X., Wang, J., Xin, H., Wan, Y."Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells". International Journal of Oncology 46.2 (2015): 691-700.
Chicago
Han, X., Yang, Z., Jiang, L., Wei, Y., Liao, M., Qian, Y., Li, Y., Huang, X., Wang, J., Xin, H., Wan, Y."Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells". International Journal of Oncology 46, no. 2 (2015): 691-700. https://doi.org/10.3892/ijo.2014.2781