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Article

Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion

  • Authors:
    • Sora Lee
    • Yoon Hee Park
    • Jin Sil Chung
    • Young Do Yoo
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Cell Biology, Graduate School of Medicine, Korea University, Seoul 136‑705, Republic of Korea
  • Pages: 2021-2028
    |
    Published online on: February 10, 2015
       https://doi.org/10.3892/ijo.2015.2889
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Abstract

Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romo1) expression has been reported to increase invasive potential and constitutive activation of nuclear factor‑κB (NF‑κB) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF‑κB activation due to Romo1 expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress‑induced invasion is mediated by Romo1 expression. The Romo1‑induced increase of invasive activity was blocked by an inhibitor of κB kinase (IKK). These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF‑κB signaling pathway. Romo1 is therefore a promising therapeutic target for diseases characterized by NF‑κB deregulation.
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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Park YH, Chung JS and Yoo YD: Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion. Int J Oncol 46: 2021-2028, 2015.
APA
Lee, S., Park, Y.H., Chung, J.S., & Yoo, Y.D. (2015). Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion. International Journal of Oncology, 46, 2021-2028. https://doi.org/10.3892/ijo.2015.2889
MLA
Lee, S., Park, Y. H., Chung, J. S., Yoo, Y. D."Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion". International Journal of Oncology 46.5 (2015): 2021-2028.
Chicago
Lee, S., Park, Y. H., Chung, J. S., Yoo, Y. D."Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion". International Journal of Oncology 46, no. 5 (2015): 2021-2028. https://doi.org/10.3892/ijo.2015.2889
Copy and paste a formatted citation
x
Spandidos Publications style
Lee S, Park YH, Chung JS and Yoo YD: Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion. Int J Oncol 46: 2021-2028, 2015.
APA
Lee, S., Park, Y.H., Chung, J.S., & Yoo, Y.D. (2015). Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion. International Journal of Oncology, 46, 2021-2028. https://doi.org/10.3892/ijo.2015.2889
MLA
Lee, S., Park, Y. H., Chung, J. S., Yoo, Y. D."Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion". International Journal of Oncology 46.5 (2015): 2021-2028.
Chicago
Lee, S., Park, Y. H., Chung, J. S., Yoo, Y. D."Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion". International Journal of Oncology 46, no. 5 (2015): 2021-2028. https://doi.org/10.3892/ijo.2015.2889
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