Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion

Lee,Sora; Park,Yoon Hee; Chung,Jin Sil; Yoo,Young Do

doi:10.3892/ijo.2015.2889

Romo1 and the NF‑κB pathway are involved in oxidative stress‑induced tumor cell invasion

Authors:
- Sora Lee
- Yoon Hee Park
- Jin Sil Chung
- Young Do Yoo
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Affiliations: Laboratory of Molecular Cell Biology, Graduate School of Medicine, Korea University, Seoul 136‑705, Republic of Korea
Published online on: February 10, 2015 https://doi.org/10.3892/ijo.2015.2889
Pages: 2021-2028

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Abstract

Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romo1) expression has been reported to increase invasive potential and constitutive activation of nuclear factor‑κB (NF‑κB) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF‑κB activation due to Romo1 expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress‑induced invasion is mediated by Romo1 expression. The Romo1‑induced increase of invasive activity was blocked by an inhibitor of κB kinase (IKK). These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF‑κB signaling pathway. Romo1 is therefore a promising therapeutic target for diseases characterized by NF‑κB deregulation.

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