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International Journal of Oncology
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Article

Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition

  • Authors:
    • Tengda Zhao
    • Fengchun Hu
    • Bin Qiao
    • Zhifeng Chen
    • Qian Tao
  • View Affiliations / Copyright

    Affiliations: Guangdong Provincial Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China, Department of Oral and Maxillofacial Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, P.R. China
  • Pages: 2205-2215
    |
    Published online on: March 13, 2015
       https://doi.org/10.3892/ijo.2015.2927
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Abstract

In recent years, researchers have found the critical role of telomerase in cellular transformation, proliferation, stemness and cell survival. High levels of telomerase reverse transcriptase (TERT) expression and telomerase activation have been reported in most cancer cells. Moreover, overexpression of human TERT (hTERT) is reported to be correlated with advanced invasive stage of the tumor progression and poor prognosis. Epithelial-mesenchymal transition (EMT), characterized by the loss of the cell-cell contact of epithelial cells and the acquisition of migratory and motile properties, is known to be a central mechanism responsible for invasiveness and metastasis of various cancers. Thus, we investigated whether hTERT plays a potential role in the development of EMT. As we expected, our clinical results showed that hTERT is overexpressed in oral epithelial dysplasia (OED) and OSCC tissues and correlates with clinical aggressiveness of oral squamous cell carcinoma (OSCC) patients. We then overexpressed hTERT in primary human oral epithelial cells (HOECS) and found that hTERT has the potential to prolong the lifespan, a process confering the characteristics of EMT by activating the Wnt/β-catenin pathway. Our findings provided an explanation for the aggressive nature of human tumors overexpressing hTERT and the possibly mechanism that links hTERT to EMT property, which represents a possible therapeutic target in highly metastatic cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, Hu F, Qiao B, Chen Z and Tao Q: Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition. Int J Oncol 46: 2205-2215, 2015.
APA
Zhao, T., Hu, F., Qiao, B., Chen, Z., & Tao, Q. (2015). Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition. International Journal of Oncology, 46, 2205-2215. https://doi.org/10.3892/ijo.2015.2927
MLA
Zhao, T., Hu, F., Qiao, B., Chen, Z., Tao, Q."Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition". International Journal of Oncology 46.5 (2015): 2205-2215.
Chicago
Zhao, T., Hu, F., Qiao, B., Chen, Z., Tao, Q."Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition". International Journal of Oncology 46, no. 5 (2015): 2205-2215. https://doi.org/10.3892/ijo.2015.2927
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, Hu F, Qiao B, Chen Z and Tao Q: Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition. Int J Oncol 46: 2205-2215, 2015.
APA
Zhao, T., Hu, F., Qiao, B., Chen, Z., & Tao, Q. (2015). Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition. International Journal of Oncology, 46, 2205-2215. https://doi.org/10.3892/ijo.2015.2927
MLA
Zhao, T., Hu, F., Qiao, B., Chen, Z., Tao, Q."Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition". International Journal of Oncology 46.5 (2015): 2205-2215.
Chicago
Zhao, T., Hu, F., Qiao, B., Chen, Z., Tao, Q."Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition". International Journal of Oncology 46, no. 5 (2015): 2205-2215. https://doi.org/10.3892/ijo.2015.2927
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