Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
June-2015 Volume 46 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 46 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression

  • Authors:
    • Hong De Xu
    • Soon-Chang Cho
    • Mi-Ae Bang
    • Chun-Sik Bae
    • Yeonshik Choi
    • Yong-Chun Li
    • Seung-Kil Lim
    • Jaegal Shim
    • Dae-Hun Park
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, P.R. China, NaturePureKorea Inc., Jeonnam 517-8-3, Republic of Korea, Research Development Team, Jeonnam Biofood Technology Center, Jeonnam, Naju 520-330, Republic of Korea, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea, Department of Bio Medical Analysis, Korea Polytechnic College, Nonsan, Chungnam 320-905, Republic of Korea, Department of Exercise Prescription, Dongshin University, Naju, Jeonnam 520-714, Republic of Korea, Comparative Biomedicine Research Branch, National Cancer Center, Goyang-si, Gyeonggi-do 411-769, Republic of Korea, Department of Oriental Medicine Materials, Dongshin University, Naju, Jeonnam 520-714, Republic of Korea
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2309-2316
    |
    Published online on: March 27, 2015
       https://doi.org/10.3892/ijo.2015.2940
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The World Health Organization (WHO) has reported that cancer is one of the most prevalent diseases and a leading cause of death worldwide. Many anticancer drug development studies have been pursued over the last few decades and several viable drugs have been discovered, such as paclitaxel, topotecan and irinotecan. Previously, our research group uncovered the cytocidal and cytostatic effects of the plant Stephania delavayi Diels. In this study, we determined the active chemical to be 6,7-di-O-acetylsinococuline (FK-3000). The FK-3000 half maximal inhibitory concentration (IC50) in MDA-MB-231 breast carcinoma cells at 48 h was 0.52 µg/ml and it induced apoptosis in a dose- and time-dependent manner. FK-3000 suppressed NF-κB nuclear translocation, decreased NF-κB phosphorylation, and decreased COX-2 protein expression. MDA-MB-231 xenografted mice were treated with FK-3000, Taxol, or their combination for 21 days. The tumor size was smallest in the co-treatment group, indicating that FK-3000 may have a synergistic effect with Taxol. FK-3000 treatment showed no adverse effects on blood cell counts, serum protein levels, or pathology. These studies demonstrate that FK-3000, isolated from S. delavayi Diels., is a promising, pathway-specific anticancer agent that exhibits low toxicity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

The World Health Organization. Cancer, Fact Sheet No. 297. February. 2014

2 

International Agency for Research on Cancer. Estimated cancer incidence, mortality and prevalence worldwide in 2012. Globocan 2012. 2012.

3 

Gupta SC, Sundaram C, Reuter S and Aggarwal BB: Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta. 1799:775–787. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Luo JL, Kamata H and Karin M: IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest. 115:2625–2632. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Kozakai N, Kikuchi E, Hasegawa M, Suzuki E, Ide H, Miyajima A, Horiguchi Y, Nakashima J, Umezawa K, Shigematsu N and Oya M: Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer. Br J Cancer. 107:652–657. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sun XF and Zhang H: NFκB and NFκBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol. 22:1387–1398. 2007.PubMed/NCBI

7 

St-Germain ME, Gagnon V, Parent S and Asselin E: Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. Mol Cancer. 3:1–11. 2004. View Article : Google Scholar

8 

Monks NR and Pardee AB: Targeting the NF-kappa B pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs. J Cell Biochem. 98:221–233. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Jang BC, Sanchez T, Schaefers HJ, Trifan OC, Liu CH, Creminon C, Huang CK and Hla T: Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. J Biol Chem. 275:39507–39515. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Karin M, Yamamoto Y and Wang QM: The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 3:17–26. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Orlowski RZ and Baldwin AS Jr: NF-kappaB as a therapeutic target in cancer. Trends Mol Med. 8:385–389. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Guttridge DC, Albanese C, Reuther JY, Pestell RG and Baldwin AS Jr: NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 19:5785–5799. 1999.PubMed/NCBI

13 

Dannenberg AJ, Altorki NK, Boyle JO, Dang C, Howe LR, Weksler BB and Subbaramaiah K: Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol. 2:544–551. 2001. View Article : Google Scholar

14 

Thun MJ, Henley SJ and Patrono C: Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst. 94:252–266. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Liu B, Shi ZL, Feng J and Tao HM: Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. Cell Biol Int. 32:494–501. 2008. View Article : Google Scholar

16 

Leng J, Han C, Demetris AJ, Michalopoulos GK and Wu T: Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology. 38:756–768. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Half E, Sun Y and Sinicrope FA: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. Cancer Lett. 251:237–246. 2007. View Article : Google Scholar

18 

Park MK, Hwang SY, Kim JO, Kwack MH, Kim JC, Kim MK and Sung YK: NS398 inhibits the growth of Hep3B human hepatocellular carcinoma cells via caspase-independent apoptosis. Mol Cells. 17:45–50. 2004.PubMed/NCBI

19 

Reddy L, Odhav B and Bhoola KD: Natural products for cancer prevention: a global perspective. Pharmacol Ther. 99:1–13. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Giovino GA: The tobacco epidemic in the United States. Am J Prev Med. 33:S318–S326. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 71:1397–1421. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW Jr and Clinton SK: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst. 95:1578–1586. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Halicka D, Ita M, Tanaka T, Kurose A and Darzynkiewicz Z: Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage. Pharmacol Rep. 60:93–100. 2008.PubMed/NCBI

24 

Kikukawa Y, Okuno Y, Tatetsu H, Nakamura M, Harada N, Ueno S, Kamizaki Y, Mitsuya H and Hata H: Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid. Int J Oncol. 33:807–814. 2008.PubMed/NCBI

25 

Meng LH, Zhang H, Hayward L, Takemura H, Shao RG and Pommier Y: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. Cancer Res. 64:9086–9092. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Park D-H, Xu HD, Shim J, Li Y-C, Lee J-H, Cho S-C, Han S-S, Lee Y-L, Lee M-J and Kwon S-W: Stephania delavayi Diels. inhibits breast carcinoma proliferation through the p38MAPK/ NF-κB/COX-2 pathway. Oncol Rep. 26:833–841. 2011.PubMed/NCBI

27 

Nawawi A, Nakamura N, Meselhy MR, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N and Ono M: In vivo antiviral activity of Stephania cepharantha against herpes simplex virus type-1. Phytother Res. 15:497–500. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Ma CM, Nakamura N, Hattori M, Kawahata T and Otake T: Inhibitory effects of triterpene-azidothymidine conjugates on proliferation of human immunodeficiency virus type 1 and its protease. Chem Pharm Bull (Tokyo). 50:877–880. 2002. View Article : Google Scholar

29 

Ma CM, Nakamura N, Miyashiro H, Hattori M, Komatsu K, Kawahata T and Otake T: Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity. Phytother Res. 16:186–189. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Baba M: Inhibitors of HIV-1 gene expression and transcription. Curr Top Med Chem. 4:871–882. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Liu WK, Wang XK and Che CT: Cytotoxic effects of sinococuline. Cancer Lett. 99:217–224. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Carraz M, Jossang A, Rasoanaivo P, Mazier D and Frappier F: Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage. Bioorg Med Chem. 16:6186–6192. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Nawawi A, Ma C, Nakamura N, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N and Ono M: Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha. Biol Pharm Bull. 22:268–274. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Itokawa H, Tsuruoka S, Takeya K, Mori N, Sonobe T, Kosemura S and Hamanaka T: An antitumor morphinane alkaloid, sinococuline, from Cocculus trilobus. Chem Pharm Bull. 35:1660–1662. 1987. View Article : Google Scholar : PubMed/NCBI

35 

Chinembiri TN, du Plessis LH, Gerber M, Hamman JH and du Plessis J: Review of natural compounds for potential skin cancer treatment. Molecules. 19:11679–11721. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Nesaretnam K and Meganathan P: Tocotrienols: inflammation and cancer. Ann NY Acad Sci. 1229:18–22. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Ganguly A, Yang H and Cabral F: Paclitaxel-dependent cell lines reveal a novel drug activity. Mol Cancer Ther. 9:2914–2923. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ghosh R, Garcia GE, Crosby K, Inoue H, Thompson IM, Troyer DA and Kumar AP: Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. Neoplasia. 9:893–899. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Kumar AP, Bhaskaran S, Ganapathy M, Crosby K, Davis MD, Kochunov P, Schoolfield J, Yeh IT, Troyer DA and Ghosh R: Akt/ cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron amurense bark extract. Clin Cancer Res. 13:2784–2794. 2007. View Article : Google Scholar : PubMed/NCBI

40 

van Hogerlinden M, Rozell BL, Ahrlund-Richter L and Toftgard R: Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling. Cancer Res. 59:3299–3303. 1999.PubMed/NCBI

41 

Miyamoto S, Maki M, Schmitt MJ, Hatanaka M and Verma IM: Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B. Proc Natl Acad Sci USA. 91:12740–12744. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Yang G, Yu F, Fu H, Lu F, Huang B, Bai L, Zhao Z, Yao L and Lu Z: Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB. Mol Cell Biochem. 302:187–194. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Herrmann JL, Beham AW, Sarkiss M, Chiao PJ, Rands MT, Bruckheimer EM, Brisbay S and McDonnell TJ: Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Exp Cell Res. 237:101–109. 1997. View Article : Google Scholar

44 

Notarbartolo M, Poma P, Perri D, Dusonchet L, Cervello M and D’Alessandro N: Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-κB activation levels and in IAP gene expression. Cancer Lett. 224:53–65. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1680–1683. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Bian X, McAllister-Lucas LM, Shao F, Schumacher KR, Feng Z, Porter AG, Castle VP and Opipari AW Jr: NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J Biol Chem. 276:48921–48929. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Ryan KM, Ernst MK, Rice NR and Vousden KH: Role of NF-kappaB in p53-mediated programmed cell death. Nature. 404:892–897. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, Hui AJ, To KF, Leung WK, Wong VW, Chung SC and Sung JJ: Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 347:2104–2110. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu HD, Cho S, Bang M, Bae C, Choi Y, Li Y, Lim S, Shim J and Park D: FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol 46: 2309-2316, 2015.
APA
Xu, H.D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y. ... Park, D. (2015). FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. International Journal of Oncology, 46, 2309-2316. https://doi.org/10.3892/ijo.2015.2940
MLA
Xu, H. D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y., Lim, S., Shim, J., Park, D."FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression". International Journal of Oncology 46.6 (2015): 2309-2316.
Chicago
Xu, H. D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y., Lim, S., Shim, J., Park, D."FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression". International Journal of Oncology 46, no. 6 (2015): 2309-2316. https://doi.org/10.3892/ijo.2015.2940
Copy and paste a formatted citation
x
Spandidos Publications style
Xu HD, Cho S, Bang M, Bae C, Choi Y, Li Y, Lim S, Shim J and Park D: FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. Int J Oncol 46: 2309-2316, 2015.
APA
Xu, H.D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y. ... Park, D. (2015). FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression. International Journal of Oncology, 46, 2309-2316. https://doi.org/10.3892/ijo.2015.2940
MLA
Xu, H. D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y., Lim, S., Shim, J., Park, D."FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression". International Journal of Oncology 46.6 (2015): 2309-2316.
Chicago
Xu, H. D., Cho, S., Bang, M., Bae, C., Choi, Y., Li, Y., Lim, S., Shim, J., Park, D."FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression". International Journal of Oncology 46, no. 6 (2015): 2309-2316. https://doi.org/10.3892/ijo.2015.2940
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team