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Article

A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells

  • Authors:
    • Zi-Jie Long
    • Le-Xun Wang
    • Fei-Meng Zheng
    • Jia-Jie Chen
    • Yu Luo
    • Xi-Xiang Tu
    • Dong-Jun Lin
    • Gui Lu
    • Quentin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, Sun Yat-sen Institute of Hematology, Guangzhou 510630, P.R. China, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, P.R. China
  • Pages: 2488-2496
    |
    Published online on: April 9, 2015
       https://doi.org/10.3892/ijo.2015.2960
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Abstract

Drug resistance still represents a major obstacle to successful chronic myeloid leukemia (CML) treatment and novel compounds or strategies to override this challenging problem are urgently required. Here, we evaluated a novel compound AKI603 against oncogenic Aurora kinase A (Aur-A) in imatinib-resistant CML cells. We found that Aur-A was highly activated in imatinib-resistant KBM5-T315I cells. AKI603 significantly inhibited the phosphorylation of Aur-A kinase at Thr288, while had little inhibitory effect on BCR-ABL kinase in both KBM5 and KBM5-T315I cells. AKI603 inhibited cell viability, and induced cell cycle arrest with polyploidy accumulation in KBM5 and KBM5-T315I cells. Moreover, inhibition of Aur-A kinase by AKI603 suppressed colony formation capacity without promoting obvious apoptosis. Importantly, AKI603 promoted cell differentiation in both CML cell types. Thus, our study suggested the potential clinical use of small molecule Aurora kinase inhibitor AKI603 to overcome imatinib resistance in CML treatment.
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1 

Savona M and Talpaz M: Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer. 8:341–350. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Gesbert F, Sellers WR, Signoretti S, Loda M and Griffin JD: BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-kinase/AKT pathway. J Biol Chem. 275:39223–39230. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Lugo TG, Pendergast AM, Muller AJ and Witte ON: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science. 247:1079–1082. 1990. View Article : Google Scholar : PubMed/NCBI

4 

Danial NN and Rothman P: JAK-STAT signaling activated by Abl oncogenes. Oncogene. 19:2523–2531. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Airiau K, Mahon FX, Josselin M, Jeanneteau M, Turcq B and Belloc F: ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+)CD38(−)population to imatinib. Exp Hematol. 40:367–378. 2012. View Article : Google Scholar

6 

Soliera AR, Mariani SA, Audia A, Lidonnici MR, Addya S, Ferrari-Amorotti G, Cattelani S, Manzotti G, Fragliasso V, Peterson L, et al: Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL- expressing cells via transcriptional repression of STAT5 and Mcl-1. Leukemia. 26:1555–1563. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Kantarjian HM, Talpaz M, Giles F, O’Brien S and Cortes J: New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med. 145:913–923. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Shah NP: Loss of response to imatinib: mechanisms and management. Hematology Am Soc Hematol Educ Program. 183–187. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Bradeen HA, Eide CA, O’Hare T, Johnson KJ, Willis SG, Lee FY, Druker BJ and Deininger MW: Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood. 108:2332–2338. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Deguchi Y, Kimura S, Ashihara E, Niwa T, Hodohara K, Fujiyama Y and Maekawa T: Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines. Leuk Res. 32:980–983. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Meraldi P, Honda R and Nigg EA: Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev. 14:29–36. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Marumoto T, Zhang D and Saya H: Aurora-A - a guardian of poles. Nat Rev Cancer. 5:42–50. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Cammareri P, Scopelliti A, Todaro M, Eterno V, Francescangeli F, Moyer MP, Agrusa A, Dieli F, Zeuner A and Stassi G: Aurora-A is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. Cancer Res. 70:4655–4665. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Shi Y, Reiman T, Li W, Maxwell CA, Sen S, Pilarski L, Daniels TR, Penichet ML, Feldman R and Lichtenstein A: Targeting aurora kinases as therapy in multiple myeloma. Blood. 109:3915–3921. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Giles FJ, Cortes J, Jones D, Bergstrom D, Kantarjian H and Freedman SJ: MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood. 109:500–502. 2007. View Article : Google Scholar

16 

Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL and Sawyers CL: Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest. 117:2562–2569. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Zheng FM, Long ZJ, Hou ZJ, Luo Y, Xu LZ, Xia JL, Lai XJ, Liu JW, Wang X, Kamran M, et al: A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther. 13:1991–2003. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Luo Y, Deng YQ, Wang J, Long ZJ, Tu ZC, Peng W, Zhang JQ, Liu Q and Lu G: Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors. Eur J Med Chem. 78:65–71. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Melo JV and Chuah C: Resistance to imatinib mesylate in chronic myeloid leukaemia. Cancer Lett. 249:121–132. 2007. View Article : Google Scholar

20 

Branford S: Chronic myeloid leukemia: molecular monitoring in clinical practice. Hematology Am Soc Hematol Educ Program. 376–383. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Nicolini FE, Hayette S, Corm S, Bachy E, Bories D, Tulliez M, Guilhot F, Legros L, Maloisel F, Kiladjian JJ, et al: Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation. Haematologica. 92:1238–1241. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Soverini S, Colarossi S, Gnani A, Rosti G, Castagnetti F, Poerio A, Iacobucci I, Amabile M, Abruzzese E, Orlandi E, et al: Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin Cancer Res. 12:7374–7379. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Carmena M and Earnshaw WC: The cellular geography of aurora kinases. Nat Rev Mol Cell Biol. 4:842–854. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Liu LL, Long ZJ, Wang LX, Zheng FM, Fang ZG, Yan M, Xu DF, Chen JJ, Wang SW, Lin DJ, et al: Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism. Mol Cancer Res. 11:1326–1336. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Long ZJ, Xu J, Yan M, Zhang JG, Guan Z, Xu DZ, Wang XR, Yao J, Zheng FM, Chu GL, et al: ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture. Cell Cycle. 7:1473–1479. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Xu DR, Huang S, Long ZJ, Chen JJ, Zou ZZ, Li J, Lin DJ and Liu Q: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. J Transl Med. 9:742011. View Article : Google Scholar : PubMed/NCBI

27 

Costello RT, Mallet F, Gaugler B, Sainty D, Arnoulet C, Gastaut JA and Olive D: Human acute myeloid leukemia CD34+/CD38− progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. Cancer Res. 60:4403–4411. 2000.PubMed/NCBI

28 

Rao J, Xu DR, Zheng FM, Long ZJ, Huang SS, Wu X, Zhou WH, Huang RW and Liu Q: Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells. J Transl Med. 9:712011. View Article : Google Scholar

29 

Yang J, Ikezoe T, Nishioka C, Nobumoto A, Udaka K and Yokoyama A: CD34+/CD38− acute myelogenous leukemia cells aberrantly express Aurora kinase A. Int J Cancer. 133:2706–2719. 2013.PubMed/NCBI

30 

Kim SJ, Jang JE, Cheong JW, Eom JI, Jeung HK, Kim Y, Hwang DY and Min YH: Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells. Korean J Hematol. 47:178–185. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ye D, Garcia-Manero G, Kantarjian HM, Xiao L, Vadhan-Raj S, Fernandez MH, Nguyen MH, Medeiros LJ and Bueso-Ramos CE: Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia. J Hematop. 2:2–8. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW and Ouchi T: BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 279:19643–19648. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, et al: Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell. 21:196–211. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Cheng C, Liu ZG, Zhang H, Xie JD, Chen XG, Zhao XQ, Wang F, Liang YJ, Chen LK, Singh S, et al: Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Mol Pharm. 9:1971–1982. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Kelly KR, Ecsedy J, Medina E, et al: The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib. J Cell Mol Med. 15:2057–2070. 2011. View Article : Google Scholar

36 

Mohan P, Castellsague J, Jiang J, Allen K, Chen H, Nemirovsky O, Spyra M, Hu K, Kluwe L, Pujana MA, et al: Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Oncotarget. 4:80–93. 2013.PubMed/NCBI

37 

Dai Y, Chen S, Venditti CA, Pei XY, Nguyen TK, Dent P and Grant S: Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate. Blood. 112:793–804. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Long Z, Wang L, Zheng F, Chen J, Luo Y, Tu X, Lin D, Lu G and Liu Q: A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells. Int J Oncol 46: 2488-2496, 2015.
APA
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X. ... Liu, Q. (2015). A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells. International Journal of Oncology, 46, 2488-2496. https://doi.org/10.3892/ijo.2015.2960
MLA
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X., Lin, D., Lu, G., Liu, Q."A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells". International Journal of Oncology 46.6 (2015): 2488-2496.
Chicago
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X., Lin, D., Lu, G., Liu, Q."A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells". International Journal of Oncology 46, no. 6 (2015): 2488-2496. https://doi.org/10.3892/ijo.2015.2960
Copy and paste a formatted citation
x
Spandidos Publications style
Long Z, Wang L, Zheng F, Chen J, Luo Y, Tu X, Lin D, Lu G and Liu Q: A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells. Int J Oncol 46: 2488-2496, 2015.
APA
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X. ... Liu, Q. (2015). A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells. International Journal of Oncology, 46, 2488-2496. https://doi.org/10.3892/ijo.2015.2960
MLA
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X., Lin, D., Lu, G., Liu, Q."A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells". International Journal of Oncology 46.6 (2015): 2488-2496.
Chicago
Long, Z., Wang, L., Zheng, F., Chen, J., Luo, Y., Tu, X., Lin, D., Lu, G., Liu, Q."A novel compound against oncogenic Aurora kinase A overcomes imatinib resistance in chronic myeloid leukemia cells". International Journal of Oncology 46, no. 6 (2015): 2488-2496. https://doi.org/10.3892/ijo.2015.2960
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