|
1
|
Haeno H, Gonen M, Davis MB, Herman JM,
Iacobuzio-Donahue CA and Michor F: Computational modeling of
pancreatic cancer reveals kinetics of metastasis suggesting optimum
treatment strategies. Cell. 148:362–375. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Fishel ML, Jiang Y, Rajeshkumar NV,
Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, et
al: Impact of APE1/Ref-1 redox inhibition on pancreatic tumor
growth. Mol Cancer Ther. 10:1698–1708. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Guillaumond F, Leca J, Olivares O, Lavaut
MN, Vidal N, Berthezène P, Dusetti NJ, Loncle C, Calvo E, Turrini
O, et al: Strengthened glycolysis under hypoxia supports tumor
symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
Proc Natl Acad Sci USA. 110:3919–3924. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zou GM, Karikari C, Kabe Y, Handa H,
Anders RA and Maitra A: The Ape-1/Ref-1 redox antagonist E3330
inhibits the growth of tumor endothelium and endothelial progenitor
cells: Therapeutic implications in tumor angiogenesis. J Cell
Physiol. 219:209–218. 2009. View Article : Google Scholar
|
|
5
|
Cannito S, Novo E, Compagnone A, Valfrè di
Bonzo L, Busletta C, Zamara E, Paternostro C, Povero D, Bandino A,
Bozzo F, et al: Redox mechanisms switch on hypoxia-dependent
epithelial-mesenchymal transition in cancer cells. Carcinogenesis.
29:2267–2278. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Zhang Y, Morris JP IV, Yan W, Schofield
HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M and Pasca di
Magliano M: Canonical wnt signaling is required for pancreatic
carcinogenesis. Cancer Res. 73:4909–4922. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Korswagen HC: Regulation of the
Wnt/beta-catenin pathway by redox signaling. Dev Cell. 10:687–688.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zou GM, Luo MH, Reed A, Kelley MR and
Yoder MC: Ape1 regulates hematopoietic differentiation of embryonic
stem cells through its redox functional domain. Blood.
109:1917–1922. 2007. View Article : Google Scholar
|
|
9
|
Mol CD, Izumi T, Mitra S and Tainer JA:
DNA-bound structures and mutants reveal abasic DNA binding by APE1
and DNA repair coordination (corrected). Nature. 403:451–456. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Luo M, Delaplane S, Jiang A, Reed A, He Y,
Fishel M, Nyland RL II, Borch RF, Qiao X, Georgiadis MM, et al:
Role of the multifunctional DNA repair and redox signaling protein
Ape1/Ref-1 in cancer and endothelial cells: Small-molecule
inhibition of the redox function of Ape1. Antioxid Redox Signal.
10:1853–1867. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Vasko MR, Guo C and Kelley MR: The
multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes
survival of neurons after oxidative stress. DNA Repair (Amst).
4:367–379. 2005. View Article : Google Scholar
|
|
12
|
Fishel ML, He Y, Reed AM, Chin-Sinex H,
Hutchins GD, Mendonca MS and Kelley MR: Knockdown of the DNA repair
and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell
and tumor growth. DNA Repair (Amst). 7:177–186. 2008. View Article : Google Scholar
|
|
13
|
Tell G, Quadrifoglio F, Tiribelli C and
Kelley MR: The many functions of APE1/Ref-1: Not only a DNA repair
enzyme. Antioxid Redox Signal. 11:601–620. 2009. View Article : Google Scholar
|
|
14
|
Kelley MR and Fishel ML: DNA repair
proteins as molecular targets for cancer therapeutics. Anticancer
Agents Med Chem. 8:417–425. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Georgiadis MM, Luo M, Gaur RK, Delaplane
S, Li X and Kelley MR: Evolution of the redox function in mammalian
apurinic/apyrimidinic endonuclease. Mutat Res. 643:54–63. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Fishel ML, He Y, Smith ML and Kelley MR:
Manipulation of base excision repair to sensitize ovarian cancer
cells to alkylating agent temozolomide. Clin Cancer Res.
13:260–267. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Madlener S, Ströbel T, Vose S, Saydam O,
Price BD, Demple B and Saydam N: Essential role for mammalian
apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere
maintenance. Proc Natl Acad Sci USA. 110:17844–17849. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Jeon BH, Gupta G, Park YC, Qi B, Haile A,
Khanday FA, Liu YX, Kim JM, Ozaki M, White AR, et al:
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO
production and vascular tone. Circ Res. 95:902–910. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Vascotto C, Fantini D, Romanello M,
Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR,
D’Ambrosio C, Scaloni A, et al: APE1/Ref-1 interacts with NPM1
within nucleoli and plays a role in the rRNA quality control
process. Mol Cell Biol. 29:1834–1854. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Poletto M, Vascotto C, Scognamiglio PL,
Lirussi L, Marasco D and Tell G: Role of the unstructured
N-terminal domain of the hAPE1 (human apurinic/apyrimidinic
endonuclease 1) in the modulation of its interaction with nucleic
acids and NPM1 (nucleophosmin). Biochem J. 452:545–557. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Vascotto C, Lirussi L, Poletto M,
Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E
and Tell G: Functional regulation of the apurinic/apyrimidinic
endonuclease 1 by nucleophosmin: Impact on tumor biology. Oncogene.
33:2876–2887. 2014. View Article : Google Scholar
|
|
22
|
Huang E, Qu D, Zhang Y, Venderova K, Haque
ME, Rousseaux MW, Slack RS, Woulfe JM and Park DS: The role of
Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation
in neuronal death. Nat Cell Biol. 12:563–571. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zou GM and Maitra A: Small-molecule
inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic
cancer cell growth and migration. Mol Cancer Ther. 7:2012–2021.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang YT, Tzeng DW, Wang CY, Hong JY and
Yang JL: APE1/Ref-1 prevents oxidative inactivation of ERK for
G1-to-S progression following lead acetate exposure. Toxicology.
305:120–129. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lee HM, Yuk JM, Shin DM, Yang CS, Kim KK,
Choi DK, Liang ZL, Kim JM, Jeon BH, Kim CD, et al:
Apurinic/apyrimidinic endonuclease 1 is a key modulator of
keratinocyte inflammatory responses. J Immunol. 183:6839–6848.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Xiong GS, Sun HL, Wu SM and Mo JZ: Small
interfering RNA against the apurinic or apyrimidinic endonuclease
enhances the sensitivity of human pancreatic cancer cells to
gemcitabine in vitro. J Dig Dis. 11:224–230. 2010.PubMed/NCBI
|
|
27
|
Lou D, Zhu L, Ding H, Dai HY and Zou GM:
Aberrant expression of redox protein Ape1 in colon cancer stem
cells. Oncol Lett. 7:1078–1082. 2014.PubMed/NCBI
|
|
28
|
Funato Y, Michiue T, Asashima M and Miki
H: The thioredoxin-related redox-regulating protein nucleoredoxin
inhibits Wnt-beta-catenin signalling through dishevelled. Nat Cell
Biol. 8:501–508. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Tetsu O and McCormick F: Beta-catenin
regulates expression of cyclin D1 in colon carcinoma cells. Nature.
398:422–426. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
30
|
Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan
CW, Wei S, Hao W, Kilgore J, Williams NS, et al: Small
molecule-mediated disruption of Wnt-dependent signaling in tissue
regeneration and cancer. Nat Chem Biol. 5:100–107. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Barnes T, Kim WC, Mantha AK, Kim SE, Izumi
T, Mitra S and Lee CH: Identification of Apurinic/apyrimidinic
endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc
mRNA. Nucleic Acids Res. 37:3946–3958. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Guttridge DC, Albanese C, Reuther JY,
Pestell RG and Baldwin AS Jr: NF-kappaB controls cell growth and
differentiation through transcriptional regulation of cyclin D1.
Mol Cell Biol. 19:5785–5799. 1999.PubMed/NCBI
|
|
33
|
Wu HH, Cheng YW, Chang JT, Wu TC, Liu WS,
Chen CY and Lee H: Subcellular localization of apurinic
endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB
activation. Oncogene. 29:4330–4340. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Hariharan D, Saied A and Kocher HM:
Analysis of mortality rates for pancreatic cancer across the world.
HPB (Oxford). 10:58–62. 2008. View Article : Google Scholar
|
|
35
|
Kikuchi A, Kishida S and Yamamoto H:
Regulation of Wnt signaling by protein-protein interaction and
post-translational modifications. Exp Mol Med. 38:1–10. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Hoffmeyer K, Raggioli A, Rudloff S, Anton
R, Hierholzer A, Del Valle I, Hein K, Vogt R and Kemler R:
Wnt/β-catenin signaling regulates telomerase in stem cells and
cancer cells. Science. 336:1549–1554. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Clevers H and Nusse R: Wnt/β-catenin
signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Sastre-Perona A and Santisteban P: Role of
the wnt pathway in thyroid cancer. Front Endocrinol (Lausanne).
3:312012.
|
|
39
|
Zeng G, Germinaro M, Micsenyi A, Monga NK,
Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, et al:
Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.
Neoplasia. 8:279–289. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Yu M, Ting DT, Stott SL, Wittner BS,
Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, et
al: RNA sequencing of pancreatic circulating tumour cells
implicates WNT signalling in metastasis. Nature. 487:510–513. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Grek CL and Tew KD: Redox metabolism and
malignancy. Curr Opin Pharmacol. 10:362–368. 2010. View Article : Google Scholar : PubMed/NCBI
|
