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Review

Molecular aspects of breast cancer resistance to drugs (Review)

  • Authors:
    • Gloria M. Calaf
    • Andrea B. Zepeda
    • Rodrigo L. Castillo
    • Carolina A. Figueroa
    • Consuelo Arias
    • Elías Figueroa
    • Jorge G. Farías
  • View Affiliations / Copyright

    Affiliations: Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1001236, Chile, Department of Chemical Engineering, Faculty of Engineering and Sciences, Universidad de la Frontera, Temuco, Chile, Pathophysiology Program, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile
  • Pages: 437-445
    |
    Published online on: June 18, 2015
       https://doi.org/10.3892/ijo.2015.3055
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Abstract

Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair mechanisms, inhibition of growth suppressors, followed by cell proliferation, tissue invasion and risk of metastasis. Less than 10% of all cancers are hereditary, and in the case of breast cancer only 8%, a phenomenon linked to genetic changes in BRCA1 or BRCA2. All the other cancers can be caused by an infection (15%) or in most cases (75%) the etiology is unknown. Patients with genetic mutations in BRCA1 or BRCA2 have 30-60% likelihood of developing a second primary breast cancer and between 11 and 45% risk of ovarian cancer, HER-2/neu is overexpressed in ~30% of human breast tumors and it has a predictive role in chemotherapy and endocrine therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Calaf GM, Zepeda AB, Castillo RL, Figueroa CA, Arias C, Figueroa E and Farías JG: Molecular aspects of breast cancer resistance to drugs (Review). Int J Oncol 47: 437-445, 2015.
APA
Calaf, G.M., Zepeda, A.B., Castillo, R.L., Figueroa, C.A., Arias, C., Figueroa, E., & Farías, J.G. (2015). Molecular aspects of breast cancer resistance to drugs (Review). International Journal of Oncology, 47, 437-445. https://doi.org/10.3892/ijo.2015.3055
MLA
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47.2 (2015): 437-445.
Chicago
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47, no. 2 (2015): 437-445. https://doi.org/10.3892/ijo.2015.3055
Copy and paste a formatted citation
x
Spandidos Publications style
Calaf GM, Zepeda AB, Castillo RL, Figueroa CA, Arias C, Figueroa E and Farías JG: Molecular aspects of breast cancer resistance to drugs (Review). Int J Oncol 47: 437-445, 2015.
APA
Calaf, G.M., Zepeda, A.B., Castillo, R.L., Figueroa, C.A., Arias, C., Figueroa, E., & Farías, J.G. (2015). Molecular aspects of breast cancer resistance to drugs (Review). International Journal of Oncology, 47, 437-445. https://doi.org/10.3892/ijo.2015.3055
MLA
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47.2 (2015): 437-445.
Chicago
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47, no. 2 (2015): 437-445. https://doi.org/10.3892/ijo.2015.3055
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