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The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival

  • Authors:
    • Yoshifumi Takahashi
    • Yasushi Saga
    • Takahiro Koyanagi
    • Yuji Takei
    • Sizuo Machida
    • Akiyo Taneichi
    • Hiroaki Mizukami
    • Yasufumi Sato
    • Shigeki Matsubara
    • Hiroyuki Fujiwara
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Tochigi, Japan, Division of Genetic Therapeutics, Center for Molecular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan, Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Copyright: © Takahashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2057-2063
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    Published online on: October 8, 2015
       https://doi.org/10.3892/ijo.2015.3193
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Abstract

Vasohibin-1 (VASH1) is expressed in vascular endothelial cells stimulated by several angiogenic growth factors and displays autocrine activity to regulate angiogenesis via a negative feedback mechanism. In this study, we investigated the effect of VASH1 on ovarian cancer progression using VASH1-expressing ovarian cancer cells in vitro and in vivo. The growth ability of ovarian cancer cells engineered to express the VASH1 gene remained unchanged in vitro. However, we showed that VASH1 secretion by tumor cells inhibited the growth of human umbilical vein endothelial cells. Further, animal experiments showed that VASH1 expression inhibited tumor angiogenesis and growth. In a murine model of peritoneal dissemination of ovarian cancer cells, VASH1 inhibited peritoneal dissemination and ascites, resulting in significantly prolonged survival in mice. This indicates that VASH1 exerts an antitumor effect on ovarian cancer by inhibiting angiogenesis in the tumor environment. These findings suggest that a novel therapy based on VASH1 could be a useful therapeutic strategy for ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Takahashi Y, Saga Y, Koyanagi T, Takei Y, Machida S, Taneichi A, Mizukami H, Sato Y, Matsubara S, Fujiwara H, Fujiwara H, et al: The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival. Int J Oncol 47: 2057-2063, 2015.
APA
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A. ... Fujiwara, H. (2015). The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival. International Journal of Oncology, 47, 2057-2063. https://doi.org/10.3892/ijo.2015.3193
MLA
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A., Mizukami, H., Sato, Y., Matsubara, S., Fujiwara, H."The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival". International Journal of Oncology 47.6 (2015): 2057-2063.
Chicago
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A., Mizukami, H., Sato, Y., Matsubara, S., Fujiwara, H."The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival". International Journal of Oncology 47, no. 6 (2015): 2057-2063. https://doi.org/10.3892/ijo.2015.3193
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi Y, Saga Y, Koyanagi T, Takei Y, Machida S, Taneichi A, Mizukami H, Sato Y, Matsubara S, Fujiwara H, Fujiwara H, et al: The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival. Int J Oncol 47: 2057-2063, 2015.
APA
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A. ... Fujiwara, H. (2015). The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival. International Journal of Oncology, 47, 2057-2063. https://doi.org/10.3892/ijo.2015.3193
MLA
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A., Mizukami, H., Sato, Y., Matsubara, S., Fujiwara, H."The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival". International Journal of Oncology 47.6 (2015): 2057-2063.
Chicago
Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A., Mizukami, H., Sato, Y., Matsubara, S., Fujiwara, H."The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival". International Journal of Oncology 47, no. 6 (2015): 2057-2063. https://doi.org/10.3892/ijo.2015.3193
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