Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review)

  • Authors:
    • Volker Schirrmacher
  • View Affiliations

  • Published online on: October 12, 2015     https://doi.org/10.3892/ijo.2015.3197
  • Pages: 2005-2016
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Abstract

Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune responses. In the present review, we describe such events for the bone marrow (BM) when blood-borne TA, released from the primary tumor or expressed by blood circulating tumor cells or DCs enters the BM stroma and parenchyma. We argue that cognate T-DC interactions in the BM result in immune responses and generation of memory T cells (MTCs) rather than tolerance because T cells in the BM show an increased level of pre-activation. The review starts with the spontaneous induction of cancer-reactive MTCs in the BM and the involvement of such MTCs in the control of tumor dormancy. The main part deals with the therapeutic potency of BM MTCs. This is a new area of research in which the authors research group has performed pioneering studies which are summarized. These include studies in animal tumor models, studies with human cells in tumor xenotransplant models and clinical studies. Based on observations of an enormous expansion capacity, longevity and therapeutic capacity of BM MTCs, a hypothesis is presented which suggests the involvement of stem-like MTCs.
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December-2015
Volume 47 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Schirrmacher V: Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review). Int J Oncol 47: 2005-2016, 2015
APA
Schirrmacher, V. (2015). Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review). International Journal of Oncology, 47, 2005-2016. https://doi.org/10.3892/ijo.2015.3197
MLA
Schirrmacher, V."Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review)". International Journal of Oncology 47.6 (2015): 2005-2016.
Chicago
Schirrmacher, V."Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review)". International Journal of Oncology 47, no. 6 (2015): 2005-2016. https://doi.org/10.3892/ijo.2015.3197