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Article

Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation

  • Authors:
    • Thanet Sophonnithiprasert
    • Sirinun Nilwarangkoon
    • Yukio Nakamura
    • Ramida Watanapokasin
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medicine, Srinkharinwirot University, Bangkok 10110, Thailand, Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
  • Pages: 2188-2196
    |
    Published online on: October 13, 2015
       https://doi.org/10.3892/ijo.2015.3204
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Abstract

The combination of TNF-related apoptosis-inducing ligand (TRAIL) and bioactive compound to enhance apoptosis in TRAIL-resistant cancer is one of cancer treatment strategies. TRAIL possesses the unique capacity to selectively induce apoptosis in cancer cells both in vitro and in vivo with little effect on normal cells. Recent studies have reported that there are many TRAIL-resistant cancers. Thus, bioactive compounds that enhance cytotoxicity of TRAIL would be potential candidates for cancer therapeutic application. This study evaluated the cytotoxic and apoptosis induction upon combined treatment of TRAIL and goniothalamin, the natural styryl-lactone compound extracted from plant Goniothalamus spp., in LoVo cells. The results showed that a combination of goniothalamin and TRAIL enhanced caspase-dependent apoptosis induction in LoVo cells via both death receptor- and mitochondrial-mediated apoptosis pathways. In addition, goniothalamin enhanced TRAIL-induced apoptosis through increased death receptor DR5 expression and decreased anti-apoptotic regulator cFLIP. Interestingly, goniothalamin increased translocation of DR5 to cell surface and consequently contributed to the enhancement of TRAIL-induced apoptosis. In conclusion, this is the first report showing the combined treatment of goniothalamin and TRAIL was able to effectively enhance TRAIL-mediated apoptosis induction in TRAIL-refractory colorectal cancer, LoVo cells. Therefore, this study may offer a strategic cancer treatment against TRAIL-resistant cancers.
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1 

Fukuda M, Hamao A, Tanaka A, Kitada M, Suzuki S, Kusama K and Sakashita H: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/APO2L) and its receptors expression in human squamous cell carcinoma of the oral cavity. Oncol Rep. 10:1113–1119. 2003.PubMed/NCBI

2 

Kichev A, Rousset CI, Baburamani AA, Levison SW, Wood TL, Gressens P, Thornton C and Hagberg H: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem. 289:9430–9439. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, et al: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 5:157–163. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:491–501. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1899–1911. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Schug ZT, Gonzalvez F, Houtkooper RH, Vaz FM and Gottlieb E: BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell Death Differ. 18:538–548. 2011. View Article : Google Scholar :

7 

Kantari C and Walczak H: Caspase-8 and bid: Caught in the act between death receptors and mitochondria. Biochim Biophys Acta. 1813:558–563. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Galligan L, Longley DB, McEwan M, Wilson TR, McLaughlin K and Johnston PG: Chemotherapy and TRAIL-mediated colon cancer cell death: The roles of p53, TRAIL receptors, and c-FLIP. Mol Cancer Ther. 4:2026–2036. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Zhang L and Fang B: Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 12:228–237. 2005. View Article : Google Scholar

10 

Lemke J, von Karstedt S, Zinngrebe J and Walczak H: Getting TRAIL back on track for cancer therapy. Cell Death Differ. 21:1350–1364. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Grambihler A, Higuchi H, Bronk SF and Gores GJ: cFLIP-L inhibits p38 MAPK activation: An additional anti-apoptotic mechanism in bile acid-mediated apoptosis. J Biol Chem. 278:26831–26837. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Nagane M, Pan G, Weddle JJ, Dixit VM, Cavenee WK and Huang HJ: Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res. 60:847–853. 2000.PubMed/NCBI

13 

Sheikh MS, Burns TF, Huang Y, Wu GS, Amundson S, Brooks KS, Fornace AJ Jr and el-Deiry WS: p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res. 58:1593–1598. 1998.PubMed/NCBI

14 

Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR and Sun SY: The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Res. 67:4981–4988. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T and Sakai T: Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res. 65:6364–6370. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Lim JH, Park JW, Choi KS, Park YB and Kwon TK: Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. Carcinogenesis. 30:729–736. 2009. View Article : Google Scholar

17 

Kikuchi H, Ohtsuki T, Koyano T, Kowithayakorn T, Sakai T and Ishibashi M: Brandisianins A-F, isoflavonoids isolated from Millettia brandisiana in a screening program for death-receptor expression enhancement activity. J Nat Prod. 70:1910–1914. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Kim YH, Park JW, Lee JY and Kwon TK: Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis. 25:1813–1820. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Yamamoto K, Makino M, Watanapokasin R, Tashiro E and Imoto M: Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface. J Antibiot (Tokyo). 65:295–300. 2012. View Article : Google Scholar

20 

Zhou W, Cao A, Wang L and Wu D: Kurarinone synergizes TRAIL-induced apoptosis in gastric cancer cells. Cell Biochem Biophys. 72:241–249. 2014. View Article : Google Scholar

21 

Han H, Xu B, Hou P, Jiang C, Liu L, Tang M, Yang X, Zhang Y and Liu Y: Icaritin sensitizes human glioblastoma cells to TRAIL-induced apoptosis. Cell Biochem Biophys. 72:533–542. 2015. View Article : Google Scholar

22 

Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P, Thompson CR, Pompei RJ, Gustafson KR, McMahon JB and Sayers TJ: Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death Dis. 6:e16662015. View Article : Google Scholar : PubMed/NCBI

23 

Son YG, Kim EH, Kim JY, Kim SU, Kwon TK, Yoon AR, Yun CO and Choi KS: Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin. Cancer Res. 67:8274–8284. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Lee DH, Kim DW, Jung CH, Lee YJ and Park D: Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol Appl Pharmacol. 279:253–265. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Tse AK, Cao HH, Cheng CY, Kwan HY, Yu H, Fong WF and Yu ZL: Indomethacin sensitizes TRAIL-resistant melanoma cells to TRAIL-induced apoptosis through ROS-mediated upregulation of death receptor 5 and downregulation of survivin. J Invest Dermatol. 134:1397–1407. 2014. View Article : Google Scholar

26 

Ahmed D, Eide PW, Eilertsen IA, Danielsen SA, Eknæs M, Hektoen M, Lind GE and Lothe RA: Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis. 2:e712013. View Article : Google Scholar : PubMed/NCBI

27 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

28 

Wattanapiromsakul C, Wangsintaweekul B, Sangprapan P, Itharat A and Keawpradub N: Goniothalamin, a cytotoxic compound, isolated from Goniothalamus macrophyllus (Blume) Hook. f & Thomson var macrophyllus Songklanakarin. J Sci Technol. 27:479–487. 2005.

29 

Inayat-Hussain SH, Annuar BO, Din LB, Ali AM and Ross D: Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells. Toxicol In Vitro. 17:433–439. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Chan KM, Rajab NF, Ishak MH, Ali AM, Yusoff K, Din LB and Inayat-Hussain SH: Goniothalamin induces apoptosis in vascular smooth muscle cells. Chem Biol Interact. 159:129–140. 2006. View Article : Google Scholar

31 

Chen WY, Wu CC, Lan YH, Chang FR, Teng CM and Wu YC: Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells. Eur J Pharmacol. 522:20–29. 2005. View Article : Google Scholar : PubMed/NCBI

32 

de Fátima A, Kohn LK, Antônio MA, de Carvalho JE and Pilli RA: (R)-Goniothalamin: Total syntheses and cytotoxic activity against cancer cell lines. Bioorg Med Chem. 13:2927–2933. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Alabsi AM, Ali R, Ali AM, Al-Dubai SA, Harun H, Abu Kasim NH and Alsalahi A: Apoptosis induction, cell cycle arrest and in vitro anticancer activity of gonothalamin in a cancer cell lines. Asian Pac J Cancer Prev. 13:5131–5136. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Petsophonsakul P, Pompimon W and Banjerdpongchai R: Apoptosis induction in human leukemic promyelocytic HL-60 and monocytic U937 cell lines by goniothalamin. Asian Pac J Cancer Prev. 14:2885–2889. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 89:271–277. 1986. View Article : Google Scholar : PubMed/NCBI

36 

Oberhammer FA, Hochegger K, Fröschl G, Tiefenbacher R and Pavelka M: Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J Cell Biol. 126:827–837. 1994. View Article : Google Scholar : PubMed/NCBI

37 

Shi J, Zheng D, Man K, Fan ST and Xu R: TRAIL: A potential agent for cancer therapy. Curr Mol Med. 3:727–736. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Nagane M, Huang HJ and Cavenee WK: The potential of TRAIL for cancer chemotherapy. Apoptosis. 6:191–197. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Shankar S and Srivastava RK: Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: Mechanisms and clinical implications. Drug Resist Updat. 7:139–156. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Buchsbaum DJ, Forero-Torres A and LoBuglio AF: TRAIL-receptor antibodies as a potential cancer treatment. Future Oncol. 3:405–409. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Krajarng A, Imoto M, Tashiro E, Fujimaki T, Shinjo S and Watanapokasin R: Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. BMC Complement Altern Med. 15:262015. View Article : Google Scholar : PubMed/NCBI

42 

Trivedi R, Maurya R and Mishra DP: Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. Cell Death Dis. 5:e14652014. View Article : Google Scholar : PubMed/NCBI

43 

Pennati M, Sbarra S, De Cesare M, Lopergolo A, Locatelli SL, Campi E, Daidone MG, Carlo-Stella C, Gianni AM and Zaffaroni N: YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation. Int J Cancer. 136:299–309. 2015. View Article : Google Scholar

44 

Yi L, Zongyuan Y, Cheng G, Lingyun Z, Guilian Y and Wei G: Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Cancer Sci. 105:520–527. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Yoon MJ, Kang YJ, Kim IY, Kim EH, Lee JA, Lim JH, Kwon TK and Choi KS: Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation. Carcinogenesis. 34:1918–1928. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Zhang S, Shen HM and Ong CN: Down-regulation of c-FLIP contributes to the sensitization effect of 3,3′-diindolylmethane on TRAIL-induced apoptosis in cancer cells. Mol Cancer Ther. 4:1972–1981. 2005. View Article : Google Scholar : PubMed/NCBI

47 

García-García C, Fumarola C, Navaratnam N, Carling D and López-Rivas A: AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochem Pharmacol. 79:853–863. 2010. View Article : Google Scholar

48 

Lin Y, Liu X, Yue P, Benbrook DM, Berlin KD, Khuri FR and Sun SY: Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. Mol Cancer Ther. 7:3556–3565. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Day TW, Huang S and Safa AR: c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells. Biochem Pharmacol. 76:1694–1704. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Safa AR and Pollok KE: Targeting the anti-apoptotic protein c-FLIP for cancer therapy. Cancers (Basel). 3:1639–1671. 2011. View Article : Google Scholar

51 

Safa AR: c-FLIP, a master anti-apoptotic regulator. Exp Oncol. 34:176–184. 2012.PubMed/NCBI

52 

Safa AR: Roles of c-FLIP in apoptosis, necroptosis, and autophagy. J Carcinog Mutagen. (Suppl 6): pii: 003. 2013.PubMed/NCBI

53 

Wilson TR, McLaughlin KM, McEwan M, Sakai H, Rogers KM, Redmond KM, Johnston PG and Longley DB: c-FLIP: A key regulator of colorectal cancer cell death. Cancer Res. 67:5754–5762. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Lee SJ, Noh HJ, Sung EG, Song IH, Kim JY, Kwon TK and Lee TJ: Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. Int J Oncol. 38:485–492. 2011. View Article : Google Scholar

55 

Murphy AC, Weyhenmeyer B, Noonan J, Kilbride SM, Schimansky S, Loh KP, Kögel D, Letai AG, Prehn JH and Murphy BM: Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis. Apoptosis. 19:629–642. 2014. View Article : Google Scholar :

56 

Kim SH, Ricci MS and El-Deiry WS: Mcl-1: A gateway to TRAIL sensitization. Cancer Res. 68:2062–2064. 2008. View Article : Google Scholar : PubMed/NCBI

57 

Clohessy JG, Zhuang J, de Boer J, Gil-Gómez G and Brady HJ: Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J Biol Chem. 281:5750–5759. 2006. View Article : Google Scholar

58 

Ozören N and El-Deiry WS: Cell surface death receptor signaling in normal and cancer cells. Semin Cancer Biol. 13:135–147. 2003. View Article : Google Scholar : PubMed/NCBI

59 

Chen JJ, Mikelis CM, Zhang Y, Gutkind JS and Zhang B: TRAIL induces apoptosis in oral squamous carcinoma cells - a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget. 4:206–217. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Ren YG, Wagner KW, Knee DA, Aza-Blanc P, Nasoff M and Deveraux QL: Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle. Mol Biol Cell. 15:5064–5074. 2004. View Article : Google Scholar : PubMed/NCBI

61 

Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB and Korsmeyer SJ: tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14:2060–2071. 2000.PubMed/NCBI

62 

Pietenpol JA and Stewart ZA: Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology. 181–182:475–481. 2002. View Article : Google Scholar

63 

van Engeland M, Nieland LJ, Ramaekers FC, Schutte B and Reutelingsperger CP: Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 31:1–9. 1998. View Article : Google Scholar : PubMed/NCBI

64 

Kuo LJ and Yang LX: Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo. 22:305–309. 2008.PubMed/NCBI

65 

Rogakou EP, Nieves-Neira W, Boon C, Pommier Y and Bonner WM: Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem. 275:9390–9395. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Ko H, Jeong MH, Jeon H, Sung GJ, So Y, Kim I, Son J, Lee SW, Yoon HG and Choi KC: Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage. Oncotarget. 6:9970–9984. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Trang KT, Kim SL, Park SB, Seo SY, Choi CH, Park JK, Moon JC, Lee ST and Kim SW: Parthenolide sensitizes human colorectal cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through mitochondrial and caspase dependent pathway. Intest Res. 12:34–41. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sophonnithiprasert T, Nilwarangkoon S, Nakamura Y and Watanapokasin R: Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. Int J Oncol 47: 2188-2196, 2015.
APA
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., & Watanapokasin, R. (2015). Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. International Journal of Oncology, 47, 2188-2196. https://doi.org/10.3892/ijo.2015.3204
MLA
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., Watanapokasin, R."Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation". International Journal of Oncology 47.6 (2015): 2188-2196.
Chicago
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., Watanapokasin, R."Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation". International Journal of Oncology 47, no. 6 (2015): 2188-2196. https://doi.org/10.3892/ijo.2015.3204
Copy and paste a formatted citation
x
Spandidos Publications style
Sophonnithiprasert T, Nilwarangkoon S, Nakamura Y and Watanapokasin R: Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. Int J Oncol 47: 2188-2196, 2015.
APA
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., & Watanapokasin, R. (2015). Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. International Journal of Oncology, 47, 2188-2196. https://doi.org/10.3892/ijo.2015.3204
MLA
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., Watanapokasin, R."Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation". International Journal of Oncology 47.6 (2015): 2188-2196.
Chicago
Sophonnithiprasert, T., Nilwarangkoon, S., Nakamura, Y., Watanapokasin, R."Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation". International Journal of Oncology 47, no. 6 (2015): 2188-2196. https://doi.org/10.3892/ijo.2015.3204
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