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Review

The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)

  • Authors:
    • Xiaofen Yuan
    • Xidi Wang
    • Kehong Bi
    • Guosheng Jiang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Rare and Uncommon Diseases of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China, Laboratory Department, People's Hospital of Zhangqiu City, Zhangqiu, Shandong, P.R. China, Department of Hematology, Qianfoshan Hospital of Shandong, Jinan, Shandong, P.R. China
  • Pages: 2028-2036
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    Published online on: October 15, 2015
       https://doi.org/10.3892/ijo.2015.3207
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Abstract

Ecotropic virus integration site-1 (EVI-1) gene, locus on chromosome 3 (3q26.2) in the human genome, was first found in the AKXD strain of mice, in a model of retrovirus-induced acute myeloid leukemia (AML) established twenty years ago. Since then, EVI-1 was regarded as one of the most invasive proto-oncogenes in human leukemia. EVI-1 can encode a unique zinc-finger protein of 145 kDa that can bind with DNA, and its overexpression was closely related to human hemopoietic diseases. Furthermore, accumulating research indicates that EVI-1 is involved in the differentiation, apoptosis and proliferation of leukemia cells. The present review focuses on the biochemical properties of EVI-1 which plays a role in myeloid malignancies.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan X, Wang X, Bi K and Jiang G: The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). Int J Oncol 47: 2028-2036, 2015.
APA
Yuan, X., Wang, X., Bi, K., & Jiang, G. (2015). The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). International Journal of Oncology, 47, 2028-2036. https://doi.org/10.3892/ijo.2015.3207
MLA
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47.6 (2015): 2028-2036.
Chicago
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47, no. 6 (2015): 2028-2036. https://doi.org/10.3892/ijo.2015.3207
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan X, Wang X, Bi K and Jiang G: The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). Int J Oncol 47: 2028-2036, 2015.
APA
Yuan, X., Wang, X., Bi, K., & Jiang, G. (2015). The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). International Journal of Oncology, 47, 2028-2036. https://doi.org/10.3892/ijo.2015.3207
MLA
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47.6 (2015): 2028-2036.
Chicago
Yuan, X., Wang, X., Bi, K., Jiang, G."The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review)". International Journal of Oncology 47, no. 6 (2015): 2028-2036. https://doi.org/10.3892/ijo.2015.3207
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