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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March-2016 Volume 48 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells

  • Authors:
    • Koji Adachi
    • Yoshio Honma
    • Takaaki Miyake
    • Koshi Kawakami
    • Tsutomu Takahashi
    • Junji Suzumiya
  • View Affiliations / Copyright

    Affiliations: Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan
  • Pages: 1095-1102
    |
    Published online on: January 19, 2016
       https://doi.org/10.3892/ijo.2016.3348
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Abstract

All-trans retinoic acid (ATRA) is valuable in differentiation therapy for acute promyelocytic leukemia (APL). However, ATRA has had limited success as a single agent, due to the development of resistance. We found that tamoxifen effectively enhanced the differentiation-inducing effect of ATRA. Tamoxifen alone inhibited the proliferation of myeloid leukemia cell lines while only slightly increasing morphologic differentiation. Tamoxifen effectively enhanced the growth-inhibiting actions of various differentiation-inducing agents. ATRA in the presence of tamoxifen increased NBT reduction and the expression of CD11b in HL-60 cells more effectively than ATRA alone. Tamoxifen also enhanced the differentiation induced by the other inducers tested. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. Tamoxifen is one of the most widely used drugs for the treatment of cancer and has few side effects. The combination of ATRA and tamoxifen might be considered for the treatment of APL patients in whom it can be difficult to apply arsenic trioxide or anthracyclines.
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Copy and paste a formatted citation
Spandidos Publications style
Adachi K, Honma Y, Miyake T, Kawakami K, Takahashi T and Suzumiya J: Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells. Int J Oncol 48: 1095-1102, 2016.
APA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., & Suzumiya, J. (2016). Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells. International Journal of Oncology, 48, 1095-1102. https://doi.org/10.3892/ijo.2016.3348
MLA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48.3 (2016): 1095-1102.
Chicago
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48, no. 3 (2016): 1095-1102. https://doi.org/10.3892/ijo.2016.3348
Copy and paste a formatted citation
x
Spandidos Publications style
Adachi K, Honma Y, Miyake T, Kawakami K, Takahashi T and Suzumiya J: Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells. Int J Oncol 48: 1095-1102, 2016.
APA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., & Suzumiya, J. (2016). Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells. International Journal of Oncology, 48, 1095-1102. https://doi.org/10.3892/ijo.2016.3348
MLA
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48.3 (2016): 1095-1102.
Chicago
Adachi, K., Honma, Y., Miyake, T., Kawakami, K., Takahashi, T., Suzumiya, J."Tamoxifen enhances the differentiation-inducing and growth-inhibitory effects of all-trans retinoic acid in acute promyelocytic leukemia cells". International Journal of Oncology 48, no. 3 (2016): 1095-1102. https://doi.org/10.3892/ijo.2016.3348
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