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Review

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

  • Authors:
    • Qian Peng
    • Yuehong Wang
    • Hongzhi Quan
    • Yiping Li
    • Zhangui Tang
  • View Affiliations / Copyright

    Affiliations: Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 59-73
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    Published online on: April 26, 2016
       https://doi.org/10.3892/ijo.2016.3501
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Abstract

Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.
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Copy and paste a formatted citation
Spandidos Publications style
Peng Q, Wang Y, Quan H, Li Y and Tang Z: Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review). Int J Oncol 49: 59-73, 2016.
APA
Peng, Q., Wang, Y., Quan, H., Li, Y., & Tang, Z. (2016). Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review). International Journal of Oncology, 49, 59-73. https://doi.org/10.3892/ijo.2016.3501
MLA
Peng, Q., Wang, Y., Quan, H., Li, Y., Tang, Z."Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)". International Journal of Oncology 49.1 (2016): 59-73.
Chicago
Peng, Q., Wang, Y., Quan, H., Li, Y., Tang, Z."Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)". International Journal of Oncology 49, no. 1 (2016): 59-73. https://doi.org/10.3892/ijo.2016.3501
Copy and paste a formatted citation
x
Spandidos Publications style
Peng Q, Wang Y, Quan H, Li Y and Tang Z: Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review). Int J Oncol 49: 59-73, 2016.
APA
Peng, Q., Wang, Y., Quan, H., Li, Y., & Tang, Z. (2016). Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review). International Journal of Oncology, 49, 59-73. https://doi.org/10.3892/ijo.2016.3501
MLA
Peng, Q., Wang, Y., Quan, H., Li, Y., Tang, Z."Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)". International Journal of Oncology 49.1 (2016): 59-73.
Chicago
Peng, Q., Wang, Y., Quan, H., Li, Y., Tang, Z."Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)". International Journal of Oncology 49, no. 1 (2016): 59-73. https://doi.org/10.3892/ijo.2016.3501
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