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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July-2016 Volume 49 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

  • Authors:
    • Shi-Xiong Huang
    • Zhong-Yan Zhao
    • Guo-Hu Weng
    • Xiang-Ying He
    • Chan-Ji Wu
    • Chuan-Yi Fu
    • Zhi-Yan Sui
    • Xiao-Ming Zhong
    • Tao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, People's Hospital of Hainan Province, Haikou, Hainan 570311, P.R. China, Department of Neurosurgery, People's Hospital of Hainan Province, Haikou, Hainan 570311, P.R. China, Department of Radiology, Ganzhou City People's Hospital, Ganzhou, Jiangxi 341000, P.R. China
  • Pages: 217-224
    |
    Published online on: May 9, 2016
       https://doi.org/10.3892/ijo.2016.3511
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Abstract

To investigate the expression and clinical significance of miR-181a and its target genes in glioblastoma multiforme (GBM), the expression levels of miR-181a and three target genes in human normal brain tissues and GBM were analyzed in silico using gene microarray, gene ontology, KEGG pathway and hierarchical clustering analysis followed by validation with quantitative RT-PCR. Our results show that miR-181a is down-regulated in GBM patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival. In conclusion, our results showed that miR-181a and it targets ANGPT2 and LAMC1 might be predictors of prognosis in GBM patients.
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Copy and paste a formatted citation
Spandidos Publications style
Huang S, Zhao Z, Weng G, He X, Wu C, Fu C, Sui Z, Zhong X and Liu T: The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. Int J Oncol 49: 217-224, 2016.
APA
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C. ... Liu, T. (2016). The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. International Journal of Oncology, 49, 217-224. https://doi.org/10.3892/ijo.2016.3511
MLA
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C., Sui, Z., Zhong, X., Liu, T."The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients". International Journal of Oncology 49.1 (2016): 217-224.
Chicago
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C., Sui, Z., Zhong, X., Liu, T."The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients". International Journal of Oncology 49, no. 1 (2016): 217-224. https://doi.org/10.3892/ijo.2016.3511
Copy and paste a formatted citation
x
Spandidos Publications style
Huang S, Zhao Z, Weng G, He X, Wu C, Fu C, Sui Z, Zhong X and Liu T: The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. Int J Oncol 49: 217-224, 2016.
APA
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C. ... Liu, T. (2016). The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients. International Journal of Oncology, 49, 217-224. https://doi.org/10.3892/ijo.2016.3511
MLA
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C., Sui, Z., Zhong, X., Liu, T."The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients". International Journal of Oncology 49.1 (2016): 217-224.
Chicago
Huang, S., Zhao, Z., Weng, G., He, X., Wu, C., Fu, C., Sui, Z., Zhong, X., Liu, T."The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients". International Journal of Oncology 49, no. 1 (2016): 217-224. https://doi.org/10.3892/ijo.2016.3511
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