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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July-2016 Volume 49 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Functional Nutrition

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Article

Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway

  • Authors:
    • Wenbin Ji
    • Jin Chen
    • Yucheng Mi
    • Guanliang Wang
    • Xinjian Xu
    • Weizhen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang 317000, P.R. China, Department of Neurology, Taizhou Hospital of Wenzhou Medical University, Taizhou, Zhejiang 317000, P.R. China
  • Pages: 181-188
    |
    Published online on: May 12, 2016
       https://doi.org/10.3892/ijo.2016.3519
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Abstract

Platelet-activating factor (PAF) and its receptor (PAFR), have been reported to participate in many cellular processes of cancer. However, little is known about their function in prostate cancer. In the present study, we found that PAFR was overexpressed in prostate cancer cells. PAF stimulation dose-dependently promoted the invasion, migration and growth of prostate cancer cells in vitro, while knockdown of PAFR inhibited the effect of PAF on prostate cancer cells. We further found that PAFR promoted prostate cancer cell growth and metastasis in vivo. Moreover, we found that PAFR activation increased MMP-3 expression and decreased E-cadherin expression of prostate cancer cells in vitro and in vivo. Finally, we found that PAFR time-dependently induced activation of ERK1/2, and ERK1/2 pathway contributed to PAFR-mediated prostate cancer cell invasion, migration and growth. Together, our findings demonstrate that PAFR can activate ERK1/2 pathway, and subsequently increase MMP-3 expression and decrease E-cadherin expression, which finally promote prostate cancer cell growth, invasion and metastasis. Thus, PAFR may act as a potential target for therapeutic use of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ji W, Chen J, Mi Y, Wang G, Xu X and Wang W: Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway. Int J Oncol 49: 181-188, 2016.
APA
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., & Wang, W. (2016). Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway. International Journal of Oncology, 49, 181-188. https://doi.org/10.3892/ijo.2016.3519
MLA
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., Wang, W."Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway". International Journal of Oncology 49.1 (2016): 181-188.
Chicago
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., Wang, W."Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway". International Journal of Oncology 49, no. 1 (2016): 181-188. https://doi.org/10.3892/ijo.2016.3519
Copy and paste a formatted citation
x
Spandidos Publications style
Ji W, Chen J, Mi Y, Wang G, Xu X and Wang W: Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway. Int J Oncol 49: 181-188, 2016.
APA
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., & Wang, W. (2016). Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway. International Journal of Oncology, 49, 181-188. https://doi.org/10.3892/ijo.2016.3519
MLA
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., Wang, W."Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway". International Journal of Oncology 49.1 (2016): 181-188.
Chicago
Ji, W., Chen, J., Mi, Y., Wang, G., Xu, X., Wang, W."Platelet-activating factor receptor activation promotes prostate cancer cell growth, invasion and metastasis via ERK1/2 pathway". International Journal of Oncology 49, no. 1 (2016): 181-188. https://doi.org/10.3892/ijo.2016.3519
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