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Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer

  • Authors:
    • Atsushi Okato
    • Yusuke Goto
    • Akira Kurozumi
    • Mayuko Kato
    • Satoko Kojima
    • Ryosuke Matsushita
    • Masaya Yonemori
    • Kazutaka Miyamoto
    • Tomohiko Ichikawa
    • Naohiko Seki
  • View Affiliations / Copyright

    Affiliations: Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan, Department of Urology, Teikyo University Chiba Medical Centre, Chiba 299-0111, Japan, Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan, Department of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
    Copyright: © Okato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 111-122
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ijo.2016.3522
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Abstract

Advanced prostate cancer (PCa) metastasizes to bone and lymph nodes, and currently available treatments cannot prevent the progression and metastasis of the disease. Therefore, an improved understanding of the molecular mechanisms of the progression and metastasis of advanced PCa using current genomic approaches is needed. Our miRNA expression signature in castration-resistant prostate cancer (CRPC) revealed that microRNA-320a (miR‑320a) was significantly reduced in cancer tissues, suggesting that miR‑320a may be a promising anticancer miRNA. The aim of this study was to investigate the functional roles of miR‑320a in naïve PCa and CRPC cells and to identify miR‑320a-regulated genes involved in PCa metastasis. The expression levels of miR‑320a were significantly reduced in naïve PCa, CRPC specimens, and PCa cell lines. Restoration of mature miR‑320a in PCa cell lines showed that miR‑320a significantly inhibited cancer cell migration and invasion. Moreover, we found that lysosomal-associated membrane protein 1 (LAMP1) was a direct target of miR‑320a in PCa cells. Silencing of LAMP1 using siRNA significantly inhibited cell proliferation, migration, and invasion in PCa cells. Overexpression of LAMP1 was observed in PCa and CRPC clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR‑320a-mediated pathways may provide important insights into the potential mechanisms of PCa metastasis.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Sridhar SS, Freedland SJ, Gleave ME, Higano C, Mulders P, Parker C, Sartor O and Saad F: Castration-resistant prostate cancer: From new pathophysiology to new treatment. Eur Urol. 65:289–299. 2014. View Article : Google Scholar

3 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Hobert O: Gene regulation by transcription factors and microRNAs. Science. 319:1785–1786. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Iorio MV and Croce CM: MicroRNAs in cancer: Small molecules with a huge impact. J Clin Oncol. 27:5848–5856. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet. 9:102–114. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Friedman RC, Farh KK, Burge CB and Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. 2009. View Article : Google Scholar :

9 

Fuse M, Kojima S, Enokida H, Chiyomaru T, Yoshino H, Nohata N, Kinoshita T, Sakamoto S, Naya Y, Nakagawa M, et al: Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer. J Hum Genet. 57:691–699. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Goto Y, Kurozumi A, Enokida H, Ichikawa T and Seki N: Functional significance of aberrantly expressed microRNAs in prostate cancer. Int J Urol. 22:242–252. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Goto Y, Kojima S, Nishikawa R, Enokida H, Chiyomaru T, Kinoshita T, Nakagawa M, Naya Y, Ichikawa T and Seki N: The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. Oncotarget. 5:7748–7759. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Nishikawa R, Goto Y, Kojima S, Enokida H, Chiyomaru T, Kinoshita T, Sakamoto S, Fuse M, Nakagawa M, Naya Y, et al: Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer. Int J Oncol. 45:401–410. 2014.PubMed/NCBI

13 

Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Kinoshita T, Yamamoto N, Nakagawa M, Naya Y, et al: Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer. Cancer Sci. 105:802–811. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Kato M, Goto Y, Matsushita R, Kurozumi A, Fukumoto I, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, et al: MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer. Int J Oncol. 47:710–718. 2015.PubMed/NCBI

15 

Kojima S, Chiyomaru T, Kawakami K, Yoshino H, Enokida H, Nohata N, Fuse M, Ichikawa T, Naya Y, Nakagawa M, et al: Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. Br J Cancer. 106:405–413. 2012. View Article : Google Scholar :

16 

Nishikawa R, Goto Y, Kurozumi A, Matsushita R, Enokida H, Kojima S, Naya Y, Nakagawa M, Ichikawa T and Seki N: MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer. Int J Urol. 22:867–877. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Goto Y, Kojima S, Nishikawa R, Kurozumi A, Kato M, Enokida H, Matsushita R, Yamazaki K, Ishida Y, Nakagawa M, et al: MicroRNA expression signature of castration-resistant prostate cancer: The microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker. Br J Cancer. 113:1055–1065. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, et al: Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 107:84–94. 2016. View Article : Google Scholar

19 

Sturge J, Caley MP and Waxman J: Bone metastasis in prostate cancer: Emerging therapeutic strategies. Nat Rev Clin Oncol. 8:357–368. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Goto Y, Nishikawa R, Kojima S, Chiyomaru T, Enokida H, Inoguchi S, Kinoshita T, Fuse M, Sakamoto S, Nakagawa M, et al: Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer. FEBS Lett. 588:1973–1982. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Hsieh IS, Chang KC, Tsai YT, Ke JY, Lu PJ, Lee KH, Yeh SD, Hong TM and Chen YL: MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway. Carcinogenesis. 34:530–538. 2013. View Article : Google Scholar

22 

Sun JY, Huang Y, Li JP, Zhang X, Wang L, Meng YL, Yan B, Bian YQ, Zhao J, Wang WZ, et al: MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin. Biochem Biophys Res Commun. 420:787–792. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Lü M, Ding K, Zhang G, Yin M, Yao G, Tian H, Lian J, Liu L, Liang M, Zhu T, et al: MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ. Sci Rep. 5:87352015. View Article : Google Scholar

24 

Hoffmans R, Städeli R and Basler K: Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Curr Biol. 15:1207–1211. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Yokoyama NN, Shao S, Hoang BH, Mercola D and Zi X: Wnt signaling in castration-resistant prostate cancer: Implications for therapy. Am J Clin Exp Urol. 2:27–44. 2014.PubMed/NCBI

26 

Sun L, Liu B, Lin Z, Yao Y, Chen Y, Li Y, Chen J, Yu D, Tang Z, Wang B, et al: MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3. Mol Cancer. 14:962015. View Article : Google Scholar : PubMed/NCBI

27 

Xishan Z, Ziying L, Jing D and Gang L: MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia. Sci Rep. 5:124602015. View Article : Google Scholar : PubMed/NCBI

28 

Jensen SS, Aaberg-Jessen C, Christensen KG and Kristensen B: Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas. Int J Clin Exp Pathol. 6:1294–1305. 2013.PubMed/NCBI

29 

Parkinson-Lawrence EJ, Dean CJ, Chang M, Hopwood JJ, Meikle PJ and Brooks DA: Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236:161–166. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Furuta K, Ikeda M, Nakayama Y, Nakamura K, Tanaka M, Hamasaki N, Himeno M, Hamilton SR and August JT: Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases. Am J Pathol. 159:449–455. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Agarwal AK, Gude RP and Kalraiya RD: Regulation of melanoma metastasis to lungs by cell surface lysosome associated membrane protein-1 (LAMP1) via galectin-3. Biochem Biophys Res Commun. 449:332–337. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Sarafian V, Jadot M, Foidart JM, Letesson JJ, Vanden Brûle F, Castronovo V, Wattiaux R and Coninck SW: Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells. Int J Cancer. 75:105–111. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE and August JT: Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 268:360–378. 1989. View Article : Google Scholar : PubMed/NCBI

34 

Krishnan V, Bane SM, Kawle PD, Naresh KN and Kalraiya RD: Altered melanoma cell surface glycosylation mediates organ specific adhesion and metastasis via lectin receptors on the lung vascular endothelium. Clin Exp Metastasis. 22:11–24. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Fortuna-Costa A, Gomes AM, Kozlowski EO, Stelling MP and Pavão MS: Extracellular galectin-3 in tumor progression and metastasis. Front Oncol. 4:1382014. View Article : Google Scholar : PubMed/NCBI

36 

Ahmed H and AlSadek DM: Galectin-3 as a potential target to prevent cancer metastasis. Clin Med Insights Oncol. 9:113–121. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Nangia-Makker P, Tait L, Balan V, Hogan V, Pienta KJ and Raz A: Regulation of prostate cancer progression by galectin-3. Am J Pathol. 174:1515–1523. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Dachineni R, Ai G, Kumar DR, Sadhu SS, Tummala H and Bhat GJ: Cyclin A2 and CDK2 as novel targets of aspirin and salicylic acid: A potential role in cancer prevention. Mol Cancer Res. 14:241–252. 2016. View Article : Google Scholar

39 

Scaltriti M, Elkabets M and Baselga J: Molecular pathways: AXL, a membrane receptor mediator of resistance to therapy. Clin Cancer Res. 22:1313–1317. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Zhou W, Wang Z, Shen N, Pi W, Jiang W, Huang J, Hu Y, Li X and Sun L: Knockdown of ANLN by lentivirus inhibits cell growth and migration in human breast cancer. Mol Cell Biochem. 398:11–19. 2015. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N, Seki N, et al: Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. Int J Oncol 49: 111-122, 2016.
APA
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R. ... Seki, N. (2016). Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. International Journal of Oncology, 49, 111-122. https://doi.org/10.3892/ijo.2016.3522
MLA
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R., Yonemori, M., Miyamoto, K., Ichikawa, T., Seki, N."Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer". International Journal of Oncology 49.1 (2016): 111-122.
Chicago
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R., Yonemori, M., Miyamoto, K., Ichikawa, T., Seki, N."Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer". International Journal of Oncology 49, no. 1 (2016): 111-122. https://doi.org/10.3892/ijo.2016.3522
Copy and paste a formatted citation
x
Spandidos Publications style
Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N, Seki N, et al: Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. Int J Oncol 49: 111-122, 2016.
APA
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R. ... Seki, N. (2016). Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. International Journal of Oncology, 49, 111-122. https://doi.org/10.3892/ijo.2016.3522
MLA
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R., Yonemori, M., Miyamoto, K., Ichikawa, T., Seki, N."Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer". International Journal of Oncology 49.1 (2016): 111-122.
Chicago
Okato, A., Goto, Y., Kurozumi, A., Kato, M., Kojima, S., Matsushita, R., Yonemori, M., Miyamoto, K., Ichikawa, T., Seki, N."Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer". International Journal of Oncology 49, no. 1 (2016): 111-122. https://doi.org/10.3892/ijo.2016.3522
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