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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October-2016 Volume 49 Issue 4

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Article

The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs

  • Authors:
    • Nan-Hee Kim
    • Chang-Won Kang
    • Hye-Jin Go
    • Chan-Hee Kim
    • Nam Gyu Park
    • Gun-Do Kim
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, College of Natural Sciences, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea, Department of Biotechnology, College of Fisheries Sciences, Pukyong National University, Nam-gu, Busan 48513, Republic of Korea
  • Pages: 1457-1468
    |
    Published online on: August 9, 2016
       https://doi.org/10.3892/ijo.2016.3651
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Abstract

Inhibition of angiogenesis has been focused on as a strategy for treating several diseases including cancer. In this study, a novel model peptide αAL14 was synthesized and used to identify its inhibitory effects on angiogenesis. The anti-angiogenic effects of αAL14 were investigated using vascular endothelial cells, HUVECs. αAL14 inhibited critical angiogenic processes including tubule formation, cell migration and cell invasion with no influence on cell proliferation in HUVECs. Activity of VEGFR2 was inhibited by αAL14 treatment in HUVECs. Additionally, activities of major subsequent downstream factors of VEGFR2 such as ERK, FAK and Akt were decreased. αAL14 affected expression of Rac1, Cdc42, Arp2 and WAVE2 which are involved in formation of lamellipodia. Moreover, αAL14 reduced NF-κB that can promote expression of several genes relating to cell invasion such as MMP2 and MMP9. Therefore, the results suggest that αAL14 has a potential to be developed as anti-angiogenic drug for treating diseases driven by abnormal angiogenesis.
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View References

1 

Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:27–31. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Sulochana KN and Ge R: Developing antiangiogenic peptide drugs for angiogenesis-related diseases. Curr Pharm Des. 13:2074–2086. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Nakamura T and Matsumoto K: Angiogenesis inhibitors: From laboratory to clinical application. Biochem Biophys Res Commun. 333:289–291. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Rosca EV, Koskimaki JE, Rivera CG, Pandey NB, Tamiz AP and Popel AS: Anti-angiogenic peptides for cancer therapeutics. Curr Pharm Biotechnol. 12:1101–1116. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Raddum AM, Hollås H, Shumilin IA, Henklein P, Kretsinger R, Fossen T and Vedeler A: The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects. Biochem Pharmacol. 95:1–15. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Olsson AK, Dimberg A, Kreuger J and Claesson-Welsh L: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 7:359–371. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Rahimi N: VEGFR-1 and VEGFR-2: Two non-identical twins with a unique physiognomy. Front Biosci. 11:818–829. 2006. View Article : Google Scholar :

9 

Ridley AJ: Life at the leading edge. Cell. 145:1012–1022. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Raftopoulou M and Hall A: Cell migration: Rho GTPases lead the way. Dev Biol. 265:23–32. 2004. View Article : Google Scholar

11 

Stetler-Stevenson WG: Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention. J Clin Invest. 103:1237–1241. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Rundhaug JE: Matrix metalloproteinases and angiogenesis. J Cell Mol Med. 9:267–285. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Adya R, Tan BK, Chen J and Randeva HS: Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: Its role in MMP-2/9 production and activation. Diabetes Care. 31:758–760. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Nam BH, Moon JY, Park EH, Kim YO, Kim DG, Kong HJ, Kim WJ, Jee YJ, An CM, Park NG, et al: Antimicrobial activity of peptides derived from olive flounder lipopolysaccharide binding protein/bactericidal permeability-increasing protein (LBP/BPI). Mar Drugs. 12:5240–5257. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ramachandran GN and Sasisekharan V: Conformation of polypeptides and proteins. Adv Protein Chem. 23:283–438. 1968. View Article : Google Scholar : PubMed/NCBI

16 

Kim NH, Jung HI, Choi WS, Son BW, Seo YB, Choi JS and Kim GD: Toluhydroquinone, the secondary metabolite of marine algae symbiotic microorganism, inhibits angiogenesis in HUVECs. Biomed Pharmacother. 70:129–139. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Kang CW, Kim NH, Jung HA, Choi HW, Kang MJ, Choi JS and Kim GD: Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion. Environ Toxicol Pharmacol. 43:140–148. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Yoon JS, Kim HM, Yadunandam AK, Kim NH, Jung HA, Choi JS, Kim CY and Kim GD: Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: Molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response. Phytomedicine. 20:1013–1022. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Bulet P, Stöcklin R and Menin L: Anti-microbial peptides: From invertebrates to vertebrates. Immunol Rev. 198:169–184. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Vizioli J and Salzet M: Antimicrobial peptides from animals: Focus on invertebrates. Trends Pharmacol Sci. 23:494–496. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Matsuzaki K: Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim Biophys Acta. 1462:1–10. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Shai Y: Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim Biophys Acta. 1462:55–70. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Zasloff M: Antimicrobial peptides of multicellular organisms. Nature. 415:389–395. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Arnaoutova I and Kleinman HK: In vitro angiogenesis: Endothelial cell tube formation on gelled basement membrane extract. Nat Protoc. 5:628–635. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Takenawa T and Miki H: WASP and WAVE family proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci. 114:1801–1809. 2001.PubMed/NCBI

26 

Tossi A, Sandri L and Giangaspero A: Amphipathic, α-helical antimicrobial peptides. Biopolymers. 55:4–30. 2000. View Article : Google Scholar

27 

Cross MJ, Dixelius J, Matsumoto T and Claesson-Welsh L: VEGF-receptor signal transduction. Trends Biochem Sci. 28:488–494. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Takahashi T, Yamaguchi S, Chida K and Shibuya M: A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20:2768–2778. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Dayanir V, Meyer RD, Lashkari K and Rahimi N: Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J Biol Chem. 276:17686–17692. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V and Ferrara N: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem. 273:30336–30343. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N and Shibuya M: Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci USA. 102:1076–1081. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Qi JH and Claesson-Welsh L: VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res. 263:173–182. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L and Welsh M: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem. 279:22267–22275. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF and Wang R: Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 172:151–162. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Calalb MB, Polte TR and Hanks SK: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol Cell Biol. 15:954–963. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, et al: Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 204:247–263. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Hall A: Rho GTPases and the actin cytoskeleton. Science. 279:509–514. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Nobes CD and Hall A: Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol. 144:1235–1244. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Ridley AJ: Rho GTPases and cell migration. J Cell Sci. 114:2713–2722. 2001.PubMed/NCBI

40 

Miki H, Yamaguchi H, Suetsugu S and Takenawa T: IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature. 408:732–735. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S and Takenawa T: PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol. 6:420–426. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Blanchoin L, Amann KJ, Higgs HN, Marchand JB, Kaiser DA and Pollard TD: Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature. 404:1007–1011. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG and Chung JG: Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Cancer Lett. 279:155–162. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Vayalil PK and Katiyar SK: Treatment of epigallocatechin-3-gallate inhibits matrix metalloproteinases-2 and -9 via inhibition of activation of mitogen-activated protein kinases, c-jun and NF-kappaB in human prostate carcinoma DU-145 cells. Prostate. 59:33–42. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Yamada T, Fialho AM, Punj V, Bratescu L, Gupta TK and Chakrabarty AM: Internalization of bacterial redox protein azurin in mammalian cells: Entry domain and specificity. Cell Microbiol. 7:1418–1431. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Mehta RR, Yamada T, Taylor BN, Christov K, King ML, Majumdar D, Lekmine F, Tiruppathi C, Shilkaitis A, Bratescu L, et al: A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 14:355–369. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Bang JY, Kim EY, Kang DK, Chang S-I, Han M-H, Baek K-H and Kang I-C: Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 10:M110.005264. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim N, Kang C, Go H, Kim C, Park NG and Kim G: The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs. Int J Oncol 49: 1457-1468, 2016.
APA
Kim, N., Kang, C., Go, H., Kim, C., Park, N.G., & Kim, G. (2016). The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs. International Journal of Oncology, 49, 1457-1468. https://doi.org/10.3892/ijo.2016.3651
MLA
Kim, N., Kang, C., Go, H., Kim, C., Park, N. G., Kim, G."The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs". International Journal of Oncology 49.4 (2016): 1457-1468.
Chicago
Kim, N., Kang, C., Go, H., Kim, C., Park, N. G., Kim, G."The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs". International Journal of Oncology 49, no. 4 (2016): 1457-1468. https://doi.org/10.3892/ijo.2016.3651
Copy and paste a formatted citation
x
Spandidos Publications style
Kim N, Kang C, Go H, Kim C, Park NG and Kim G: The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs. Int J Oncol 49: 1457-1468, 2016.
APA
Kim, N., Kang, C., Go, H., Kim, C., Park, N.G., & Kim, G. (2016). The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs. International Journal of Oncology, 49, 1457-1468. https://doi.org/10.3892/ijo.2016.3651
MLA
Kim, N., Kang, C., Go, H., Kim, C., Park, N. G., Kim, G."The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs". International Journal of Oncology 49.4 (2016): 1457-1468.
Chicago
Kim, N., Kang, C., Go, H., Kim, C., Park, N. G., Kim, G."The novel model peptide, αAL14, regulates angiogenesis by inhibiting VEGFR 2-mediated signaling in HUVECs". International Journal of Oncology 49, no. 4 (2016): 1457-1468. https://doi.org/10.3892/ijo.2016.3651
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