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Article

Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc

  • Authors:
    • Yucai Wei
    • Lei Zhao
    • Wenting He
    • Jingwei Yang
    • Chunyu Geng
    • Yusheng Chen
    • Tao Liu
    • Hao Chen
    • Yumin Li
  • View Affiliations / Copyright

    Affiliations: The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA
  • Pages: 2055-2063
    |
    Published online on: August 29, 2016
       https://doi.org/10.3892/ijo.2016.3674
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Abstract

Gastric cancer (GC) is the fifth most common cancer worldwide and the third leading cause of global cancer-related death. Benzo[a]pyrene (BaP), a Group Ⅰ carcinogen categorized by the IARC, is a cumulative foodborne carcinogen and ubiquitous environmental pollutant with potent carcinogenic properties. However, the function and mechanism of BaP exposure on GC progression remains unclear. We investigated the role of BaP in human GC progression to identify potential mechanism underlining its carcinogenic activity. After exposure to various concentrations of BaP, human GC cells SGC-7901 and MNK-45 showed an increased capability of proliferation, migration and invasion. Further study indicated that BaP promotes the expression of matrix metalloproteinase-9 (MMP9) and c-myc at mRNA and protein level, and activates Aryl hydrocarbon receptor (AhR) and ERK pathway. Moreover, BaP-induced overexpression of MMP9 and c-myc were attenuated by the ERK inhibitor U0126 and AhR inhibitor resveratrol, respectively. These data suggest that BaP promotes proliferation and metastasis of GC cells through upregulation of MMP9 and c-myc expression, and this was likely mediated via the AhR and ERK signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wei Y, Zhao L, He W, Yang J, Geng C, Chen Y, Liu T, Chen H and Li Y: Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. Int J Oncol 49: 2055-2063, 2016.
APA
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y. ... Li, Y. (2016). Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. International Journal of Oncology, 49, 2055-2063. https://doi.org/10.3892/ijo.2016.3674
MLA
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y., Liu, T., Chen, H., Li, Y."Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc". International Journal of Oncology 49.5 (2016): 2055-2063.
Chicago
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y., Liu, T., Chen, H., Li, Y."Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc". International Journal of Oncology 49, no. 5 (2016): 2055-2063. https://doi.org/10.3892/ijo.2016.3674
Copy and paste a formatted citation
x
Spandidos Publications style
Wei Y, Zhao L, He W, Yang J, Geng C, Chen Y, Liu T, Chen H and Li Y: Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. Int J Oncol 49: 2055-2063, 2016.
APA
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y. ... Li, Y. (2016). Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. International Journal of Oncology, 49, 2055-2063. https://doi.org/10.3892/ijo.2016.3674
MLA
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y., Liu, T., Chen, H., Li, Y."Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc". International Journal of Oncology 49.5 (2016): 2055-2063.
Chicago
Wei, Y., Zhao, L., He, W., Yang, J., Geng, C., Chen, Y., Liu, T., Chen, H., Li, Y."Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc". International Journal of Oncology 49, no. 5 (2016): 2055-2063. https://doi.org/10.3892/ijo.2016.3674
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