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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November-2016 Volume 49 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways

  • Authors:
    • Min-Hui Li
    • Ping Yang
    • Tai Yang
    • Kun Zhang
    • Yang Liu
    • Jin Liu
    • Li-Mei Li
    • Xing-Yan Luo
    • Shu-Xia Yang
    • Qiang Zou
    • Chong-Jie Zhang
  • View Affiliations / Copyright

    Affiliations: College of Basic and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, P.R. China, Center of Science and Research, Chengdu Medical College, Chengdu, Sichuan, P.R. China, School of Biomedicine Sciences, Chengdu Medical College, Chengdu, Sichuan, P.R. China
  • Pages: 2127-2134
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/ijo.2016.3684
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Abstract

Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy have received considerable attention in recent years. However, the poor water solubility of most benzothiazole derivatives has limited their clinical application. We developed BD926, a novel water-soluble benzothiazole derivative and showed here that it could inhibit the proliferation and induce apoptosis of human Ramos B-lymphoma cells. We further showed that BD926 triggered apoptosis through both mitochondria and endoplasmic reticulum pathways. Moreover, BD926 caused cell cycle arrest at G0/G1 stage. Furthermore, accumulation of reactive oxygen species (ROS) were observed after BD926 treatment and ROS inhibitor was able to attenuate BD926-induced apoptosis, which suggested that BD926-induced apoptosis may be due to over-producing ROS. These results demonstrate the anticancer effects of BD926 in cell models and raise the possibility for the application of BD926 in cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Li M, Yang P, Yang T, Zhang K, Liu Y, Liu J, Li L, Luo X, Yang S, Zou Q, Zou Q, et al: A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. Int J Oncol 49: 2127-2134, 2016.
APA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J. ... Zhang, C. (2016). A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. International Journal of Oncology, 49, 2127-2134. https://doi.org/10.3892/ijo.2016.3684
MLA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49.5 (2016): 2127-2134.
Chicago
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49, no. 5 (2016): 2127-2134. https://doi.org/10.3892/ijo.2016.3684
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Yang P, Yang T, Zhang K, Liu Y, Liu J, Li L, Luo X, Yang S, Zou Q, Zou Q, et al: A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. Int J Oncol 49: 2127-2134, 2016.
APA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J. ... Zhang, C. (2016). A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. International Journal of Oncology, 49, 2127-2134. https://doi.org/10.3892/ijo.2016.3684
MLA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49.5 (2016): 2127-2134.
Chicago
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49, no. 5 (2016): 2127-2134. https://doi.org/10.3892/ijo.2016.3684
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