miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes

  • Authors:
    • Xingyi Kuang
    • Chunmei Wei
    • Tao Zhang
    • Zesong Yang
    • Jianxiang Chi
    • Li Wang
  • View Affiliations

  • Published online on: September 13, 2016     https://doi.org/10.3892/ijo.2016.3689
  • Pages: 1921-1930
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Abstract

miR-378 has been proven to inhibit cell growth, migration and invasion in different types of cancers. In this study, we found that miR-378 was commonly downregulated in the bone marrow cells obtained from myelodysplastic syndrome (MDS) patients. We further investigated the role of miR-378 in the proliferation and apoptosis of SKM-1 cells, an acute myeloid leukemia cell line established in the leukemic phase during the progression of MDS to AML (MDS/AML). Results indicated that overexpression of miR-378 in SKM-1 cells interfered with proliferation via inducing apoptosis and G0/G1-phase cell cycle arrest, and suppressive effect of miR-378 on MDS/AML cells may be mediated partly through Bcl-w and CDC40. Moreover, apoptosis induced by miR-378 correlated with increased expression of Bax and activation of caspase-3, -8 and -9. Taken together, our data support a critical role for miR-378 in the pathogenesis of MDS and provide a novel therapeutic target in this complex disease.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kuang X, Wei C, Zhang T, Yang Z, Chi J and Wang L: miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. Int J Oncol 49: 1921-1930, 2016
APA
Kuang, X., Wei, C., Zhang, T., Yang, Z., Chi, J., & Wang, L. (2016). miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. International Journal of Oncology, 49, 1921-1930. https://doi.org/10.3892/ijo.2016.3689
MLA
Kuang, X., Wei, C., Zhang, T., Yang, Z., Chi, J., Wang, L."miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes". International Journal of Oncology 49.5 (2016): 1921-1930.
Chicago
Kuang, X., Wei, C., Zhang, T., Yang, Z., Chi, J., Wang, L."miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes". International Journal of Oncology 49, no. 5 (2016): 1921-1930. https://doi.org/10.3892/ijo.2016.3689