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Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

  • Authors:
    • Wei-Ching Chen
    • Hui-Ping Hsu
    • Chung-Yen Li
    • Ya-Ju Yang
    • Yu-Hsuan Hung
    • Chien-Yu Cho
    • Chih-Yang Wang
    • Tzu-Yang Weng
    • Ming-Derg Lai
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C., Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1881-1889
    |
    Published online on: September 15, 2016
       https://doi.org/10.3892/ijo.2016.3691
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Abstract

Cancer stem cell (CSC) markers have been identified for CSC isolation and proposed as therapeutic targets in various types of cancers. CD90, one of the characterized markers in liver and gastric cancer, is shown to promote cancer formation. However, the underexpression level of CD90 in ovarian cancer cells and the evidence supporting the cellular mechanism have not been investigated. In the present study, we found that the DNA copy number of CD90 is correlated with mRNA expression in ovarian cancer tissue and the ovarian cancer patients with higher CD90 have good prognosis compared to the patients with lower CD90. Although the expression of CD90 in human ovarian cancer SKOV3 cells enhances the cell proliferation by MTT and anchorage-dependent growth assay, CD90 inhibits the anchorage-independent growth ability in vitro and tumor formation in vivo. CD90 overexpression suppresses the sphere-forming ability and ALDH activity and enhances the cell apoptosis, indicating that CD90 may reduce the cell growth by the properties of CSC and anoikis. Furthermore, CD90 reduces the expression of other CSC markers, including CD133 and CD24. The inhibition of CD133 is attenuated by the mutant CD90, which is replaced with RLE domain into RLD domain. Importantly, the CD90-regulated inhibition of CD133 expression, anchorage-independent growth and signal transduction of mTOR and AMPK are restored by the β3 integrin shRNA. Our results provide evidence that CD90 mediates the antitumor formation by interacting with β3 integrin, which provides new insight that can potentially be applied in the development of therapeutic strategies in ovarian cancer.
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1 

Sadikovic B, Al-Romaih K, Squire JA and Zielenska M: Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics. 9:394–408. 2008. View Article : Google Scholar

2 

Claus EB, Risch N and Thompson WD: Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet. 48:232–242. 1991.PubMed/NCBI

3 

Easton DF, Bishop DT, Ford D and Crockford GP; The Breast Cancer Linkage Consortium. Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families. Am J Hum Genet. 52:678–701. 1993.PubMed/NCBI

4 

Welcsh PL and King MC: BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet. 10:705–713. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Yang H, Das P, Yu Y, Mao W, Wang Y, Baggerly K, Wang Y, Marquez RT, Bedi A, Liu J, et al: NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms. Oncotarget. 7:3018–3032. 2016.

6 

Bellio M, Leal LM, Scharfstein J and Dos Reis GA: Interactions between CD3 and Thy1 T cell activation pathways: Blockade of CD3-mediated T lymphocyte activation induced by immobilized anti-Thy1 antibodies. Cell Immunol. 135:534–540. 1991. View Article : Google Scholar : PubMed/NCBI

7 

Avalos AM, Valdivia AD, Muñoz N, Herrera-Molina R, Tapia JC, Lavandero S, Chiong M, Burridge K, Schneider P, Quest AF, et al: Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphav-beta3 integrin that activates PKCalpha and RhoA. J Cell Sci. 122:3462–3471. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Schubert K, Gutknecht D, Köberle M, Anderegg U and Saalbach A: Melanoma cells use Thy-1 (CD90) on endothelial cells for metastasis formation. Am J Pathol. 182:266–276. 2013. View Article : Google Scholar

9 

Fiore VF, Ju L, Chen Y, Zhu C and Barker TH: Dynamic catch of a Thy-1-α5β1+syndecan-4 trimolecular complex. Nat Commun. 5:48862014. View Article : Google Scholar

10 

Kong M, Muñoz N, Valdivia A, Alvarez A, Herrera-Molina R, Cárdenas A, Schneider P, Burridge K, Quest AF and Leyton L: Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta. 1833:1409–1420. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Jiang J, Zhang Y, Chuai S, Wang Z, Zheng D, Xu F, Zhang Y, Li C, Liang Y and Chen Z: Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype. Oncogene. 31:671–682. 2012. View Article : Google Scholar

12 

Yan X, Luo H, Zhou X, Zhu B, Wang Y and Bian X: Identification of CD90 as a marker for lung cancer stem cells in A549 and H446 cell lines. Oncol Rep. 30:2733–2740. 2013.PubMed/NCBI

13 

Tang KH, Dai YD, Tong M, Chan YP, Kwan PS, Fu L, Qin YR, Tsao SW, Lung HL, Lung ML, et al: A CD90+ tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer. Cancer Res. 73:2322–2332. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, Ngai P, Chu PW, Lam CT, Poon RT and Fan ST: Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell. 13:153–166. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Zhu L, Zhang W, Wang J and Liu R: Evidence of CD90+CXCR4+ cells as circulating tumor stem cells in hepatocellular carcinoma. Tumour Biol. 36:5353–5360. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Pang YB, Zhong JH, Luo XL, Ou C, Guo Z, Xiang BD, Peng NF and Li LQ: Clinicopathological characteristics and liver stem cell marker expression in hepatocellular carcinoma involving bile duct tumor thrombi. Tumour Biol. 37:5879–5884. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chen WC, Chang YS, Hsu HP, Yen MC, Huang HL, Cho CY, Wang CY, Weng TY, Lai PT, Chen CS, et al: Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer. Oncotarget. 6:42923–42937. 2015.PubMed/NCBI

18 

Lung HL, Bangarusamy DK, Xie D, Cheung AK, Cheng Y, Kumaran MK, Miller L, Liu ET, Guan XY, Sham JS, et al: THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma. Oncogene. 24:6525–6532. 2005.PubMed/NCBI

19 

Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP and Wang N: The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 149:1–10. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Abeysinghe HR, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert NL, Keng P and Wang N: THY1 expression is associated with tumor suppression of human ovarian cancer. Cancer Genet Cytogenet. 143:125–132. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Tiveron MC, Barboni E, Pliego Rivero FB, Gormley AM, Seeley PJ, Grosveld F and Morris R: Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Nature. 355:745–748. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Hermosilla T, Muñoz D, Herrera-Molina R, Valdivia A, Muñoz N, Nham SU, Schneider P, Burridge K, Quest AF and Leyton L: Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication. Biochim Biophys Acta. 1783:1111–1120. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, Aylwin ML, Schneider P, Quest AF and Leyton L: Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1. PLoS One. 7:e342952012. View Article : Google Scholar

24 

Zhou Y, Hagood JS, Lu B, Merryman WD and Murphy-Ullrich JE: Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation. J Biol Chem. 285:22382–22393. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Győrffy B, Surowiak P, Budczies J and Lánczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 8:e822412013. View Article : Google Scholar

28 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBio-Portal. Sci Signal. 6:pl12013. View Article : Google Scholar

29 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Rothenberg SM and Settleman J: Discovering tumor suppressor genes through genome-wide copy number analysis. Curr Genomics. 11:297–310. 2010. View Article : Google Scholar :

31 

Chen J, Zhang J, Zhao Y, Li J and Fu M: Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 135:909–917. 2009. View Article : Google Scholar

32 

Fuh KC, Shin JY, Kapp DS, Brooks RA, Ueda S, Urban RR, Chen LM and Chan JK: Survival differences of Asian and Caucasian epithelial ovarian cancer patients in the United States. Gynecol Oncol. 136:491–497. 2015. View Article : Google Scholar

33 

Bouvard D, Pouwels J, De Franceschi N and Ivaska J: Integrin inactivators: Balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol. 14:430–442. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Takayama S, Ishii S, Ikeda T, Masamura S, Doi M and Kitajima M: The relationship between bone metastasis from human breast cancer and integrin αvβ3 expression. Anticancer Res. 25(1A): 79–83. 2005.PubMed/NCBI

35 

Sloan EK, Pouliot N, Stanley KL, Chia J, Moseley JM, Hards DK and Anderson RL: Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res. 8:R202006. View Article : Google Scholar : PubMed/NCBI

36 

Zutter MM, Santoro SA, Staatz WD and Tsung YL: Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc Natl Acad Sci USA. 92:7411–7415. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Kaur S, Kenny HA, Jagadeeswaran S, Zillhardt MR, Montag AG, Kistner E, Yamada SD, Mitra AK and Lengyel E: β3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol. 175:2184–2196. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Hongo K, Tanaka J, Tsuno NH, Kawai K, Nishikawa T, Shuno Y, Sasaki K, Kaneko M, Hiyoshi M, Sunami E, et al: CD133(−) cells, derived from a single human colon cancer cell line, are more resistant to 5-fluorouracil (FU) than CD133(+) cells, dependent on the β1-integrin signaling. J Surg Res. 175:278–288. 2012. View Article : Google Scholar

39 

Lathia JD, Gallagher J, Heddleston JM, Wang J, Eyler CE, Macswords J, Wu Q, Vasanji A, McLendon RE, Hjelmeland AB, et al: Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell. 6:421–432. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Rentala S, Yalavarthy PD and Mangamoori LN: Alpha1 and beta1 integrins enhance the homing and differentiation of cultured prostate cancer stem cells. Asian J Androl. 12:548–555. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA: Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells. Tissue Eng Part C Methods. 19:68–79. 2013. View Article : Google Scholar

42 

Ito K and Suda T: Metabolic requirements for the maintenance of self-renewing stem cells. Nat Rev Mol Cell Biol. 15:243–256. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Horsley V, Aliprantis AO, Polak L, Glimcher LH and Fuchs E: NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 132:299–310. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Moore N and Lyle S: Quiescent, slow-cycling stem cell populations in cancer: A review of the evidence and discussion of significance. J Oncol. 2011:3960762011. View Article : Google Scholar

45 

Kolev VN, Wright QG, Vidal CM, Ring JE, Shapiro IM, Ricono J, Weaver DT, Padval MV, Pachter JA and Xu Q: PI3K/ mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. Cancer Res. 75:446–455. 2015. View Article : Google Scholar

46 

Cao Y, Liu X, Lu W, Chen Y, Wu X, Li M, Wang XA, Zhang F, Jiang L, Zhang Y, et al: Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer. Cancer Lett. 360:141–150. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Wang Z, Liu P, Chen Q, Deng S, Liu X, Situ H, Zhong S, Hann S and Lin Y: Targeting AMPK signaling pathway to overcome drug resistance for cancer therapy. Curr Drug Targets. 17:853–864. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Hsu H, Li C, Yang Y, Hung Y, Cho C, Wang C, Weng T and Lai M: Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. Int J Oncol 49: 1881-1889, 2016.
APA
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C. ... Lai, M. (2016). Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. International Journal of Oncology, 49, 1881-1889. https://doi.org/10.3892/ijo.2016.3691
MLA
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C., Wang, C., Weng, T., Lai, M."Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin". International Journal of Oncology 49.5 (2016): 1881-1889.
Chicago
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C., Wang, C., Weng, T., Lai, M."Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin". International Journal of Oncology 49, no. 5 (2016): 1881-1889. https://doi.org/10.3892/ijo.2016.3691
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Hsu H, Li C, Yang Y, Hung Y, Cho C, Wang C, Weng T and Lai M: Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. Int J Oncol 49: 1881-1889, 2016.
APA
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C. ... Lai, M. (2016). Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin. International Journal of Oncology, 49, 1881-1889. https://doi.org/10.3892/ijo.2016.3691
MLA
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C., Wang, C., Weng, T., Lai, M."Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin". International Journal of Oncology 49.5 (2016): 1881-1889.
Chicago
Chen, W., Hsu, H., Li, C., Yang, Y., Hung, Y., Cho, C., Wang, C., Weng, T., Lai, M."Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin". International Journal of Oncology 49, no. 5 (2016): 1881-1889. https://doi.org/10.3892/ijo.2016.3691
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