SMC1A promotes growth and migration of prostate cancer in vitro and in vivo

Corrigendum in: /10.3892/ijo.2021.5283

  • Authors:
    • Xiu-Wu Pan
    • Si-Shun Gan
    • Jian-Qing Ye
    • Ying-Hui Fan
    • Υi Hong
    • Chuan-Min Chu
    • Yi Gao
    • Lin Li
    • Xi Liu
    • Lu Chen
    • Yi Huang
    • Hong Xu
    • Ji-Zhong Ren
    • Lei Yin
    • Fa-Jun Qu
    • Hai Huang
    • Xin-Gang Cui
    • Dan-Feng Xu
  • View Affiliations

  • Published online on: September 19, 2016     https://doi.org/10.3892/ijo.2016.3697
  • Pages: 1963-1972
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Abstract

Structural maintenance of chromosome 1 alpha (SMC1A) gene has been reported to be related to tumor development in some types of human cancers. However, the misregulation of SMC1A and its functions in castration-resistant prostate cancer (CRPC) have not been well understood. In the present study, we found that SMC1A was elevated in androgen-independent PCa cell lines PC-3 and DU-145 compared to androgen sensitive LNCap and 22RV1 cells by qPCR and western blot assay. Knockdown of SMC1A inhibited cell growth, colony formation and cell migration abilities of PC-3 and DU145 cells by MTT, colony formation and transwell assays, and affected cell cycle progression in PC-3 and DU145 cells by flow cytometry. Moreover, SMC1A knockdown significantly reduced tumor growth in vivo in a nude mouse model. Additionally, we also found that the expression of SMC1A gene was higher in prostate cancer tissues than in the adjacent normal tissues by immunohistochemical staining, and was positively correlated to tumor metastasis and recurrence by Oncomine database mining. Taken together, the present study indicates that SMC1A may play an important role in malignant transformation of PCa under conditions of androgen deprivation and act as a new target for PCa diagnosis and treatment.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Pan X, Gan S, Ye J, Fan Y, Hong Υ, Chu C, Gao Y, Li L, Liu X, Chen L, Chen L, et al: SMC1A promotes growth and migration of prostate cancer in vitro and in vivo Corrigendum in /10.3892/ijo.2021.5283. Int J Oncol 49: 1963-1972, 2016
APA
Pan, X., Gan, S., Ye, J., Fan, Y., Hong, Υ., Chu, C. ... Xu, D. (2016). SMC1A promotes growth and migration of prostate cancer in vitro and in vivo Corrigendum in /10.3892/ijo.2021.5283. International Journal of Oncology, 49, 1963-1972. https://doi.org/10.3892/ijo.2016.3697
MLA
Pan, X., Gan, S., Ye, J., Fan, Y., Hong, Υ., Chu, C., Gao, Y., Li, L., Liu, X., Chen, L., Huang, Y., Xu, H., Ren, J., Yin, L., Qu, F., Huang, H., Cui, X., Xu, D."SMC1A promotes growth and migration of prostate cancer in vitro and in vivo Corrigendum in /10.3892/ijo.2021.5283". International Journal of Oncology 49.5 (2016): 1963-1972.
Chicago
Pan, X., Gan, S., Ye, J., Fan, Y., Hong, Υ., Chu, C., Gao, Y., Li, L., Liu, X., Chen, L., Huang, Y., Xu, H., Ren, J., Yin, L., Qu, F., Huang, H., Cui, X., Xu, D."SMC1A promotes growth and migration of prostate cancer in vitro and in vivo Corrigendum in /10.3892/ijo.2021.5283". International Journal of Oncology 49, no. 5 (2016): 1963-1972. https://doi.org/10.3892/ijo.2016.3697