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Article

Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells

  • Authors:
    • Ran‑Xi Zhang
    • Yang Li
    • Dong‑Dong Tian
    • Yang Liu
    • Wu Nian
    • Xiang Zou
    • Qian‑Zhao Chen
    • Lin‑Yun Zhou
    • Zhong‑Liang Deng
    • Bai‑Cheng He
  • View Affiliations / Copyright

    Affiliations: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China, Department of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
  • Pages: 1973-1982
    |
    Published online on: September 21, 2016
       https://doi.org/10.3892/ijo.2016.3701
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Abstract

Although multiple chemotherapeutic agents have been used for osteosarcoma (OS) treatment, their mechanisms need further study. Ursolic acid (UA), a pentacyclic triterpenoid, can reduce cell proliferation and induce apoptosis in various cancer cells, such as OS. However, the exact mechanism underlying this function remains unclear. In this study, we investigated the anti‑proliferative effect of UA in human OS 143B cells and dissected the possible molecular mechanism underlying this effect. We demonstrated that UA can reduce cell proliferation, induce apoptosis and arrest cell cycle in 143B cells, as well as inhibit OS tumor growth in a mouse xenograft model. Using a luciferase reporter assay, we found that the Wnt/β‑catenin signaling is inhibited by UA in 143B cells. Correspondingly, the expression level and nuclear translocation of β‑catenin are both decreased by UA. Exogenous expression of β‑catenin attenuates the anticancer effect of UA in 143B cells, while knockdown of β‑catenin enhances this effect. UA increases the expression level of p53 in a concentration‑dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. Moreover, inhibition of p53 partly reverses the UA‑induced downregulation of β‑catenin, as do the targets of Wnt/β‑catenin signaling, such as c‑Myc and cyclin D1. Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/β-catenin signaling, which may be mediated partly by upregulating the expression of p53.
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1 

Cheng S, Zhang X, Huang N, Qiu Q, Jin Y and Jiang D: Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways. BMC Cancer. 16:253. 2016. View Article : Google Scholar

2 

Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, Kotz R, Salzer-Kuntschik M, Werner M, Winkelmann W, et al: Prognostic factors in high-grade osteo-sarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 20:776–790. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Kempf-Bielack B, Bielack SS, Jürgens H, Branscheid D, Berdel WE, Exner GU, Göbel U, Helmke K, Jundt G, Kabisch H, et al: Osteosarcoma relapse after combined modality therapy: An analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS). J Clin Oncol. 23:559–568. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Ando K, Heymann M-F, Stresing V, Mori K, Rédini F and Heymann D: Current therapeutic strategies and novel approaches in osteosarcoma. Cancers (Basel). 5:591–616. 2013. View Article : Google Scholar

5 

Chou AJ and Gorlick R: Chemotherapy resistance in osteosarcoma: Current challenges and future directions. Expert Rev Anticancer Ther. 6:1075–1085. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Prasad S, Yadav VR, Sung B, Gupta SC, Tyagi AK and Aggarwal BB: Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment. Oncotarget. 7:13182–13196. 2016.PubMed/NCBI

7 

Pu F, Chen F, Lin S, Chen S, Zhang Z, Wang B and Shao Z: The synergistic anticancer effect of cisplatin combined with Oldenlandia diffusa in osteosarcoma MG-63 cell line in vitro. Onco Targets Ther. 9:255–263. 2016.PubMed/NCBI

8 

Chen S, Wang Z, Huang Y, O'Barr SA, Wong RA, Yeung S and Chow MSS: Ginseng and anticancer drug combination to improve cancer chemotherapy: A critical review. Evid Based Complement Alternat Med. 2014:1689402014.PubMed/NCBI

9 

Zhang Y, Kong C, Zeng Y, Wang L, Li Z, Wang H, Xu C and Sun Y: Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Mol Carcinog. 49:374–385. 2010.PubMed/NCBI

10 

Huang CY, Lin CY, Tsai CW and Yin MC: Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. Toxicol In Vitro. 25:1274–1280. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Shanmugam MK, Ong TH, Kumar AP, Lun CK, Ho PC, Wong PTH, Hui KM and Sethi G: Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. PLoS One. 7:e324762012. View Article : Google Scholar : PubMed/NCBI

12 

Deng L, Zhang R, Tang F, Li C, Xing Y-Y and Xi T: Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation. Chin J Nat Med. 12:15–19. 2014.PubMed/NCBI

13 

Lin J, Chen Y, Wei L, Hong Z, Sferra TJ and Peng J: Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. Int J Oncol. 43:1666–1674. 2013.PubMed/NCBI

14 

Gayathri R, Priya DKD, Gunassekaran GR and Sakthisekaran D: Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pac J Cancer Prev. 10:933–938. 2009.

15 

Choi BM, Park R, Pae HO, Yoo JC, Kim YC, Jun CD, Jung BH, Oh GS, So HS, Kim YM, et al: Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells. Pharmacol Toxicol. 86:53–58. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Harmand PO, Duval R, Delage C and Simon A: Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. Int J Cancer. 114:1–11. 2005. View Article : Google Scholar

17 

Lee YH, Kumar NC and Glickman RD: Modulation of photo-chemical damage in normal and malignant cells by naturally occurring compounds. Photochem Photobiol. 88:1385–1395. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lee YH, Wang E, Kumar N and Glickman RD: Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. Apoptosis. 19:816–828. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wu CC, Cheng CH, Lee YH, Chang IL, Chen HY, Hsieh CP and Chueh PJ: Ursolic acid triggers apoptosis in human osteosarcoma cells via caspase activation and the ERK1/2 MAPK pathway. J Agric Food Chem. 64:4220–4226. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Behrens J and Lustig B: The Wnt connection to tumorigenesis. Int J Dev Biol. 48:477–487. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Chen C, Zhao M, Tian A, Zhang X, Yao Z and Ma X: Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells. Oncotarget. 6:17570–17583. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Tian J, He H and Lei G: Wnt/β-catenin pathway in bone cancers. Tumour Biol. 35:9439–9445. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hoang BH, Kubo T, Healey JH, Sowers R, Mazza B, Yang R, Huvos AG, Meyers PA and Gorlick R: Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int J Cancer. 109:106–111. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Kansara M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, Dobrovic A, Slavin J, Choong PF, Simmons PJ, et al: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 119:837–851. 2009. View Article : Google Scholar : PubMed/NCBI

25 

He BC, Gao JL, Luo X, Luo J, Shen J, Wang L, Zhou Q, Wang YT, Luu HH, Haydon RC, et al: Ginsenoside Rg3 inhibits colorectal tumor growth through the downregulation of Wnt/β-catenin signaling. Int J Oncol. 38:437–445. 2011. View Article : Google Scholar

26 

Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, et al: A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc. 2:1236–1247. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Liu YZ, Zhang RX, Wang X, Meng ZJ, Huang J, Wu K, Luo JY, Zuo GW, Chen L, et al: Oridonin inhibits the proliferation of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Int J Oncol. 45:795–803. 2014.PubMed/NCBI

28 

Park HR and Park YK: Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. J Korean Med Sci. 10:360–367. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Sadot E, Geiger B, Oren M and Ben-Ze'ev A: Down-regulation of beta-catenin by activated p53. Mol Cell Biol. 21:6768–6781. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Serra M and Hattinger CM: The pharmacogenomics of osteosarcoma. Pharmacogenomics J. May 31–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

31 

Hattinger CM, Fanelli M, Tavanti E, Vella S, Ferrari S, Picci P and Serra M: Advances in emerging drugs for osteosarcoma. Expert Opin Emerg Drugs. 20:495–514. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Chen P, Wang H, Yang F, Chen H, He W and Wang J: Curcumin promotes osteosarcoma cell death by activating miR-125a/ERRα signal pathway. J Cell Biochem. May 27–2016.(Epub ahead of print). View Article : Google Scholar

33 

Siegel HJ and Pressey JG: Current concepts on the surgical and medical management of osteosarcoma. Expert Rev Anticancer Ther. 8:1257–1269. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Xie T, Ren HY, Lin HQ, Mao JP, Zhu T, Wang SD and Ye ZM: Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway. Int J Oncol. 48:2098–2112. 2016.PubMed/NCBI

35 

Kashyap D, Tuli HS and Sharma AK: Ursolic acid (UA): A metabolite with promising therapeutic potential. Life Sci. 146:201–213. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Meng Y, Lin ZM, Ge N, Zhang DL, Huang J and Kong F: Ursolic acid induces apoptosis of prostate cancer cells via the PI3K/Akt/mTOR pathway. Am J Chin Med. 43:1471–1486. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Lu BJ, Wang YQ, Wei XJ, Rong LQ, Wei D, Yan CM, Wang DJ and Sun JY: Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Rep. 5:1033–1036. 2012.PubMed/NCBI

38 

Park JH, Kwon HY, Sohn EJ, Kim KA, Kim B, Jeong SJ, Song JH, Koo JS and Kim SH: Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. Pharmacol Rep. 65:1366–1374. 2013. View Article : Google Scholar

39 

Li J, Liang X and Yang X: Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. Oncol Rep. 28:501–510. 2012.PubMed/NCBI

40 

Kahn M: Can we safely target the WNT pathway? Nat Rev Drug Discov. 13:513–532. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature. 434:843–850. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Hsieh HY, Shen CH, Lin R-I, Feng YM, Huang SY, Wang YH, Wu SF, Hsu CD and Chan MW: Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways. Cancer Lett. 370:56–65. 2016. View Article : Google Scholar

43 

Vilchez V, Turcios L, Zaytseva Y, Stewart R, Lee EY, Maynard E, Shah MB, Daily MF, Tzeng CW, Davenport D, et al: Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma. Am J Surg. 212:238–245. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Haydon RC, Deyrup A, Ishikawa A, Heck R, Jiang W, Zhou L, Feng T, King D, Cheng H, Breyer B, et al: Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer. 102:338–342. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Wang WG, Chen SJ, He JS, Li JS and Zang XF: The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway. Tumour Biol. 37:8869–8877. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Hasty P and Christy BA: p53 as an intervention target for cancer and aging. Pathobiol Aging Age Relat Dis. 3:32013.

47 

Bansal N, Kadamb R, Mittal S, Vig L, Sharma R, Dwarakanath BS and Saluja D: Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PLoS One. 6:e261562011. View Article : Google Scholar : PubMed/NCBI

48 

Nam H and Kim M-M: Ursolic acid induces apoptosis of SW480 cells via p53 activation. Food Chem Toxicol. 62:579–583. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Levina E, Oren M and Ben-Ze'ev A: Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics. Oncogene. 23:4444–4453. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Mishra R: Glycogen synthase kinase 3 beta: Can it be a target for oral cancer. Mol Cancer. 9:1442010. View Article : Google Scholar : PubMed/NCBI

51 

Fuentes RG, Toume K, Arai MA, Sadhu SK, Ahmed F and Ishibashi M: Scopadulciol, isolated from Scoparia dulcis, induces β-catenin degradation and overcomes tumor necrosis factor-related apoptosis ligand resistance in AGS human gastric adenocarcinoma cells. J Nat Prod. 78:864–872. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Xie BS, He XX, Ai ZL and Yao SK: Involvement of β-catenin in matrine-induced autophagy and apoptosis in WB-F344 cells. Mol Med Rep. 9:2547–2553. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang RX, Li Y, Tian DD, Liu Y, Nian W, Zou X, Chen QZ, Zhou LY, Deng ZL, He BC, He BC, et al: Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells. Int J Oncol 49: 1973-1982, 2016.
APA
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X. ... He, B. (2016). Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells. International Journal of Oncology, 49, 1973-1982. https://doi.org/10.3892/ijo.2016.3701
MLA
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X., Chen, Q., Zhou, L., Deng, Z., He, B."Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells". International Journal of Oncology 49.5 (2016): 1973-1982.
Chicago
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X., Chen, Q., Zhou, L., Deng, Z., He, B."Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells". International Journal of Oncology 49, no. 5 (2016): 1973-1982. https://doi.org/10.3892/ijo.2016.3701
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang RX, Li Y, Tian DD, Liu Y, Nian W, Zou X, Chen QZ, Zhou LY, Deng ZL, He BC, He BC, et al: Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells. Int J Oncol 49: 1973-1982, 2016.
APA
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X. ... He, B. (2016). Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells. International Journal of Oncology, 49, 1973-1982. https://doi.org/10.3892/ijo.2016.3701
MLA
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X., Chen, Q., Zhou, L., Deng, Z., He, B."Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells". International Journal of Oncology 49.5 (2016): 1973-1982.
Chicago
Zhang, R., Li, Y., Tian, D., Liu, Y., Nian, W., Zou, X., Chen, Q., Zhou, L., Deng, Z., He, B."Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells". International Journal of Oncology 49, no. 5 (2016): 1973-1982. https://doi.org/10.3892/ijo.2016.3701
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