Open Access

Circulating tumor cell clusters: What we know and what we expect (Review)

  • Authors:
    • Yupeng Hong
    • Francia Fang
    • Qi Zhang
  • View Affiliations

  • Published online on: October 24, 2016     https://doi.org/10.3892/ijo.2016.3747
  • Pages: 2206-2216
  • Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The major cause of cancer-associated mortality is tumor metastasis, a disease that is far from understood. Many studies have observed circulating tumor cells (CTCs) in patients' circulation systems, and a few latest investigations showed that CTC clusters have a potentially high capacity of metastasis. The capture and analysis of CTC clusters offer new insights into tumor metastasis and can facilitate the development of cancer treatments. We reviewed the research history of the CTC clusters, as well as the technologies used for detecting and isolating CTC clusters. In addition, we discuss the characteristics of CTC clusters and their roles in tumor dissemination. Clinical relevance of CTC clusters was also implicated in currently limited data. Moving forward, the next frontier in this field is to develop more efficient capture methods and decipher conundrums of characterization of CTC clusters. This will ultimately identify the clinical value of CTC clusters as a biomarker and therapeutic target.
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December-2016
Volume 49 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hong Y, Fang F and Zhang Q: Circulating tumor cell clusters: What we know and what we expect (Review). Int J Oncol 49: 2206-2216, 2016
APA
Hong, Y., Fang, F., & Zhang, Q. (2016). Circulating tumor cell clusters: What we know and what we expect (Review). International Journal of Oncology, 49, 2206-2216. https://doi.org/10.3892/ijo.2016.3747
MLA
Hong, Y., Fang, F., Zhang, Q."Circulating tumor cell clusters: What we know and what we expect (Review)". International Journal of Oncology 49.6 (2016): 2206-2216.
Chicago
Hong, Y., Fang, F., Zhang, Q."Circulating tumor cell clusters: What we know and what we expect (Review)". International Journal of Oncology 49, no. 6 (2016): 2206-2216. https://doi.org/10.3892/ijo.2016.3747