|
1
|
Coomans de Brachène A and Demoulin JB:
FOXO transcription factors in cancer development and therapy. Cell
Mol Life Sci. 73:1159–1172. 2016. View Article : Google Scholar
|
|
2
|
Eijkelenboom A and Burgering BMT: FOXOs:
Signalling integrators for homeostasis maintenance. Nat Rev Mol
Cell Biol. 14:83–97. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Charitou P, Rodriguez-Colman M, Gerrits J,
van Triest M, Groot Koerkamp M, Hornsveld M, Holstege F,
Verhoeven-Duif NM and Burgering BM: FOXOs support the metabolic
requirements of normal and tumor cells by promoting IDH1
expression. EMBO Rep. 16:456–466. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
van der Vos KE and Coffer PJ: The
extending network of FOXO transcriptional target genes. Antioxid
Redox Signal. 14:579–592. 2011. View Article : Google Scholar
|
|
5
|
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo
P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: Akt
promotes cell survival by phosphorylating and inhibiting a Forkhead
transcription factor. Cell. 96:857–868. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ho KK, Myatt SS and Lam EW: Many forks in
the path: Cycling with FoxO. Oncogene. 27:2300–2311. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Naka K, Hoshii T, Muraguchi T, Tadokoro Y,
Ooshio T, Kondo Y, Nakao S, Motoyama N and Hirao A: TGF-beta-FOXO
signalling maintains leukaemia-initiating cells in chronic myeloid
leukaemia. Nature. 463:676–680. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tenbaum SP, Ordóñez-Morán P, Puig I,
Chicote I, Arqués O, Landolfi S, Fernández Y, Herance JR, Gispert
JD, Mendizabal L, et al: β-catenin confers resistance to PI3K and
AKT inhibitors and subverts FOXO3a to promote metastasis in colon
cancer. Nat Med. 18:892–901. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Calnan DR and Brunet A: The FoxO code.
Oncogene. 27:2276–2288. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
van der Horst A and Burgering BM:
Stressing the role of FoxO proteins in lifespan and disease. Nat
Rev Mol Cell Biol. 8:440–450. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Van Der Heide LP, Hoekman MF and Smidt MP:
The ins and outs of FoxO shuttling: Mechanisms of FoxO
translocation and transcriptional regulation. Biochem J.
380:297–309. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Cancer Genome Atlas Research Network.
Comprehensive genomic characterization defines human glioblastoma
genes and core pathways. Nature. 455:1061–1068. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Sunayama J, Sato A, Matsuda K, Tachibana
K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K,
et al: FoxO3a functions as a key integrator of cellular signals
that control glioblastoma stem-like cell differentiation and
tumorigenicity. Stem Cells. 29:1327–1337. 2011.PubMed/NCBI
|
|
14
|
Lau CJ, Koty Z and Nalbantoglu J:
Differential response of glioma cells to FOXO1-directed therapy.
Cancer Res. 69:5433–5440. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Masui K, Tanaka K, Akhavan D, Babic I,
Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, et al: mTOR
complex 2 controls glycolytic metabolism in glioblastoma through
FoxO acetylation and upregulation of c-Myc. Cell Metab. 18:726–739.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Firat E and Niedermann G: FoxO proteins or
loss of functional p53 maintain stemness of glioblastoma stem cells
and survival after ionizing radiation plus PI3K/mTOR inhibition.
Oncotarget. Jul 19–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Clark PM, Mai WX, Cloughesy TF and
Nathanson DA: Emerging approaches for targeting metabolic
vulnerabilities in malignant glioma. Curr Neurol Neurosci Rep.
16:172016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Liebelt BD, Shingu T, Zhou X, Ren J, Shin
SA and Hu J: Glioma stem cells: Signaling, microenvironment, and
therapy. Stem Cells Int. 2016:78498902016. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Province P, Griguer CE, Han X, Nabors LB
and Shaykh HF: Hypoxia, angiogenesis and mechanisms for invasion of
malignant gliomas. Evolution of the Molecular Biology of Brain
Tumors and the Therapeutic Implications. Lichtor T: InTech; Rijeka:
2013, View Article : Google Scholar
|
|
21
|
Jensen KS, Binderup T, Jensen KT,
Therkelsen I, Borup R, Nilsson E, Multhaupt H, Bouchard C,
Quistorff B, Kjaer A, et al: FoxO3A promotes metabolic adaptation
to hypoxia by antagonizing Myc function. EMBO J. 30:4554–4570.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ronellenfitsch MW, Brucker DP, Burger MC,
Wolking S, Tritschler F, Rieger J, Wick W, Weller M and Steinbach
JP: Antagonism of the mammalian target of rapamycin selectively
mediates metabolic effects of epidermal growth factor receptor
inhibition and protects human malignant glioma cells from
hypoxia-induced cell death. Brain. 132:1509–1522. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Berra E, Benizri E, Ginouvès A, Volmat V,
Roux D and Pouysségur J: HIF prolyl-hydroxylase 2 is the key oxygen
sensor setting low steady-state levels of HIF-1alpha in normoxia.
EMBO J. 22:4082–4090. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Skurk C, Maatz H, Kim HS, Yang J, Abid MR,
Aird WC and Walsh K: The Akt-regulated forkhead transcription
factor FOXO3a controls endothelial cell viability through
modulation of the caspase-8 inhibitor FLIP. J Biol Chem.
279:1513–1525. 2004. View Article : Google Scholar
|
|
25
|
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang
F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, et al: IkappaB kinase
promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell.
117:225–237. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Nakamura N, Ramaswamy S, Vazquez F,
Signoretti S, Loda M and Sellers WR: Forkhead transcription factors
are critical effectors of cell death and cell cycle arrest
downstream of PTEN. Mol Cell Biol. 20:8969–8982. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Tran H, Brunet A, Grenier JM, Datta SR,
Fornace AJ Jr, DiStefano PS, Chiang LW and Greenberg ME: DNA repair
pathway stimulated by the forkhead transcription factor FOXO3a
through the Gadd45 protein. Science. 296:530–534. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Brummelkamp TR, Bernards R and Agami R: A
system for stable expression of short interfering RNAs in mammalian
cells. Science. 296:550–553. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Maurer GD, Tritschler I, Adams B,
Tabatabai G, Wick W, Stupp R and Weller M: Cilengitide modulates
attachment and viability of human glioma cells, but not sensitivity
to irradiation or temozolomide in vitro. Neuro Oncol. 11:747–756.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Henze AT, Riedel J, Diem T, Wenner J,
Flamme I, Pouyseggur J, Plate KH and Acker T: Prolyl hydroxylases 2
and 3 act in gliomas as protective negative feedback regulators of
hypoxia-inducible factors. Cancer Res. 70:357–366. 2010. View Article : Google Scholar
|
|
31
|
Wagenknecht B, Schulz JB, Gulbins E and
Weller M: Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of
malignant glioma cells at the level of caspase 8 processing. Cell
Death Differ. 5:894–900. 1998. View Article : Google Scholar
|
|
32
|
Wanka C, Brucker DP, Bähr O,
Ronellenfitsch M, Weller M, Steinbach JP and Rieger J: Synthesis of
cytochrome c oxidase 2: A p53-dependent metabolic regulator that
promotes respiratory function and protects glioma and colon cancer
cells from hypoxia-induced cell death. Oncogene. 31:3764–3776.
2012. View Article : Google Scholar
|
|
33
|
Dyer BW, Ferrer FA, Klinedinst DK and
Rodriguez R: A noncommercial dual luciferase enzyme assay system
for reporter gene analysis. Anal Biochem. 282:158–161. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Schneider CA, Rasband WS and Eliceiri KW:
NIH Image to ImageJ: 25 years of image analysis. Nat Methods.
9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Obexer P, Geiger K, Ambros PF, Meister B
and Ausserlechner MJ: FKHRL1-mediated expression of Noxa and Bim
induces apoptosis via the mitochondria in neuroblastoma cells. Cell
Death Differ. 14:534–547. 2007. View Article : Google Scholar
|
|
36
|
Bakker WJ, Harris IS and Mak TW: FOXO3a is
activated in response to hypoxic stress and inhibits HIF1-induced
apoptosis via regulation of CITED2. Mol Cell. 28:941–953. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Ullah MS, Davies AJ and Halestrap AP: The
plasma membrane lactate transporter MCT4, but not MCT1, is
up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J
Biol Chem. 281:9030–9037. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Harter PN, Jennewein L, Baumgarten P,
Ilina E, Burger MC, Thiepold AL, Tichy J, Zörnig M, Senft C,
Steinbach JP, et al: Immunohistochemical assessment of
phosphorylated mTORC1-pathway proteins in human brain tumors. PLoS
One. 10:e01271232015. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Rong Y, Durden DL, Van Meir EG and Brat
DJ: ‘Pseudopalisading’ necrosis in glioblastoma: A familiar
morphologic feature that links vascular pathology, hypoxia, and
angiogenesis. J Neuropathol Exp Neurol. 65:529–539. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Ghaffari S, Jagani Z, Kitidis C, Lodish HF
and Khosravi-Far R: Cytokines and BCR-ABL mediate suppression of
TRAIL-induced apoptosis through inhibition of forkhead FOXO3a
transcription factor. Proc Natl Acad Sci USA. 100:6523–6528. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Modur V, Nagarajan R, Evers BM and
Milbrandt J: FOXO proteins regulate tumor necrosis factor-related
apoptosis inducing ligand expression. Implications for PTEN
mutation in prostate cancer. J Biol Chem. 277:47928–47937. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Warr MR, Binnewies M, Flach J, Reynaud D,
Garg T, Malhotra R, Debnath J and Passegué E: FOXO3A directs a
protective autophagy program in haematopoietic stem cells. Nature.
494:323–327. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Biggs WH III, Cavenee WK and Arden KC:
Identification and characterization of members of the FKHR (FOX O)
subclass of winged-helix transcription factors in the mouse. Mamm
Genome. 12:416–425. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Kops GJ and Burgering BM: Forkhead
transcription factors: New insights into protein kinase B (c-akt)
signaling. J Mol Med (Berl). 77:656–665. 1999. View Article : Google Scholar
|
|
45
|
Chong ZZ, Li F and Maiese K: Activating
Akt and the brain’s resources to drive cellular survival and
prevent inflammatory injury. Histol Histopathol. 20:299–315.
2005.
|
|
46
|
Kops GJ, Dansen TB, Polderman PE, Saarloos
I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH and Burgering
BM: Forkhead transcription factor FOXO3a protects quiescent cells
from oxidative stress. Nature. 419:316–321. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Steinbach JP, Wolburg H, Klumpp A, Probst
H and Weller M: Hypoxia-induced cell death in human malignant
glioma cells: Energy deprivation promotes decoupling of
mitochondrial cytochrome c release from caspase processing and
necrotic cell death. Cell Death Differ. 10:823–832. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Yoshioka K, Takahashi H, Homma T, Saito M,
Oh KB, Nemoto Y and Matsuoka H: A novel fluorescent derivative of
glucose applicable to the assessment of glucose uptake activity of
Escherichia coli. Biochim Biophys Acta. 1289:5–9. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Ramaswamy S, Nakamura N, Sansal I,
Bergeron L and Sellers WR: A novel mechanism of gene regulation and
tumor suppression by the transcription factor FKHR. Cancer Cell.
2:81–91. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Semenza GL: HIF-1 mediates metabolic
responses to intra-tumoral hypoxia and oncogenic mutations. J Clin
Invest. 123:3664–3671. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Carruthers A, DeZutter J, Ganguly A and
Devaskar SU: Will the original glucose transporter isoform please
stand up! Am J Physiol Endocrinol Metab. 297:E836–E848. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Bhattacharya S, Michels CL, Leung MK,
Arany ZP, Kung AL and Livingston DM: Functional role of p35srj, a
novel p300/CBP binding protein, during transactivation by HIF-1.
Genes Dev. 13:64–75. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Schwartzenberg-Bar-Yoseph F, Armoni M and
Karnieli E: The tumor suppressor p53 down-regulates glucose
transporters GLUT1 and GLUT4 gene expression. Cancer Res.
64:2627–2633. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
You H, Yamamoto K and Mak TW: Regulation
of transactivation-independent proapoptotic activity of p53 by
FOXO3a. Proc Natl Acad Sci USA. 103:9051–9056. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Loughery J, Cox M, Smith LM and Meek DW:
Critical role for p53-serine 15 phosphorylation in stimulating
transactivation at p53-responsive promoters. Nucleic Acids Res.
42:7666–7680. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Parsons DW, Jones S, Zhang X, Lin JC,
Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, et
al: An integrated genomic analysis of human glioblastoma
multiforme. Science. 321:1807–1812. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Shi J, Zhang L, Shen A, Zhang J, Wang Y,
Zhao Y, Zou L, Ke Q, He F, Wang P, et al: Clinical and biological
significance of forkhead class box O 3a expression in glioma:
Mediation of glioma malignancy by transcriptional regulation of
p27kip1. J Neurooncol. 98:57–69. 2010. View Article : Google Scholar
|
|
58
|
Hsu AL, Murphy CT and Kenyon C: Regulation
of aging and age-related disease by DAF-16 and heat-shock factor.
Science. 300:1142–1145. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Yeo H, Lyssiotis CA, Zhang Y, Ying H,
Asara JM, Cantley LC and Paik JH: FoxO3 coordinates metabolic
pathways to maintain redox balance in neural stem cells. EMBO J.
32:2589–2602. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Ferber EC, Peck B, Delpuech O, Bell GP,
East P and Schulze A: FOXO3a regulates reactive oxygen metabolism
by inhibiting mitochondrial gene expression. Cell Death Differ.
19:968–979. 2012. View Article : Google Scholar :
|
|
61
|
Emerling BM, Weinberg F, Liu JL, Mak TW
and Chandel NS: PTEN regulates p300-dependent hypoxia-inducible
factor 1 transcriptional activity through Forkhead transcription
factor 3a (FOXO3a). Proc Natl Acad Sci USA. 105:2622–2627. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wanka C, Steinbach JP and Rieger J:
Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects
glioma cells from starvation-induced cell death by up-regulating
respiration and improving cellular redox homeostasis. J Biol Chem.
287:33436–33446. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Riley T, Sontag E, Chen P and Levine A:
Transcriptional control of human p53-regulated genes. Nat Rev Mol
Cell Biol. 9:402–412. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Kurinna S, Stratton SA, Tsai WW, Akdemir
KC, Gu W, Singh P, Goode T, Darlington GJ and Barton MC: Direct
activation of forkhead box O3 by tumor suppressors p53 and p73 is
disrupted during liver regeneration in mice. Hepatology.
52:1023–1032. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Renault VM, Thekkat PU, Hoang KL, White
JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui
PR, Xuan Z, et al: The pro-longevity gene FoxO3 is a direct target
of the p53 tumor suppressor. Oncogene. 30:3207–3221. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
You H, Jang Y, You-Ten AI, Okada H, Liepa
J, Wakeham A, Zaugg K and Mak TW: p53-dependent inhibition of
FKHRL1 in response to DNA damage through protein kinase SGK1. Proc
Natl Acad Sci USA. 101:14057–14062. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Miyaguchi Y, Tsuchiya K and Sakamoto K:
p53 negatively regulates the transcriptional activity of FOXO3a
under oxidative stress. Cell Biol Int. 33:853–860. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Fu W, Ma Q, Chen L, Li P, Zhang M,
Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, et al: MDM2
acts downstream of p53 as an E3 ligase to promote FOXO
ubiquitination and degradation. J Biol Chem. 284:13987–14000. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Wang F, Marshall CB, Yamamoto K, Li GY,
Plevin MJ, You H, Mak TW and Ikura M: Biochemical and structural
characterization of an intramolecular interaction in FOXO3a and its
binding with p53. J Mol Biol. 384:590–603. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Wang F, Marshall CB and Ikura M:
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis:
Structural and functional versatility in target recognition. Cell
Mol Life Sci. 70:3989–4008. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Chan DA, Sutphin PD, Nguyen P, Turcotte S,
Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, et al:
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by
chemical synthetic lethality. Sci Transl Med. 3:94ra702011.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Horsman MR and Vaupel P:
Pathophysiological basis for the formation of the tumor
microenvironment. Front Oncol. 6:662016. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
LaGory EL and Giaccia AJ: The
ever-expanding role of HIF in tumour and stromal biology. Nat Cell
Biol. 18:356–365. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Weinmann M, Belka C, Güner D, Goecke B,
Müller I, Bamberg M and Jendrossek V: Array-based comparative gene
expression analysis of tumor cells with increased apoptosis
resistance after hypoxic selection. Oncogene. 24:5914–5922. 2005.
View Article : Google Scholar : PubMed/NCBI
|
