RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model

  • Authors:
    • Giovanna Turconi
    • Debora Scaldaferri
    • Marco Fabbri
    • Laura Monti
    • Marta Lualdi
    • Edoardo Pedrini
    • Laura Gribaldo
    • Roberto Taramelli
    • Francesco Acquati
  • View Affiliations

  • Published online on: November 9, 2016     https://doi.org/10.3892/ijo.2016.3763
  • Pages: 2637-2646
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Abstract

Ribonucleases (RNases) are hydrolytic enzymes endowed with the ability to either process or degrade ribonucleic acids. Among the many biological functions assigned to RNases, a growing attention has been recently devoted to the control of cancer growth, in the attempt to bring novel therapeutic approaches to clinical oncology. Indeed, several enzymes belonging to different ribonuclease families have been reported in the last decade to display a marked oncosuppressive activity in a wide range of experimental models. The human RNASET2 gene, the only member of the highly conserved T2/Rh/S family of endoribonucleolytic enzymes described in our species, has been shown to display oncosuppressive roles in both in vitro and in vivo models representing several human malignancies. In the present study, we extend previous findings obtained in ovarian cancer models to shed further light on the cell-autonomous roles played by this gene in the context of its oncosuppresive role and to show that RNASET2 silencing can significantly affect the transcriptional output in one of the most thoroughly investigated human ovarian cancer cell lines. Moreover, we report for the first time that RNASET2-mediated changes in the cell transcriptome are in part mediated by its apparent ability to affect the cell's microRNA expression pattern.
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December-2016
Volume 49 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Turconi G, Scaldaferri D, Fabbri M, Monti L, Lualdi M, Pedrini E, Gribaldo L, Taramelli R and Acquati F: RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model. Int J Oncol 49: 2637-2646, 2016
APA
Turconi, G., Scaldaferri, D., Fabbri, M., Monti, L., Lualdi, M., Pedrini, E. ... Acquati, F. (2016). RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model. International Journal of Oncology, 49, 2637-2646. https://doi.org/10.3892/ijo.2016.3763
MLA
Turconi, G., Scaldaferri, D., Fabbri, M., Monti, L., Lualdi, M., Pedrini, E., Gribaldo, L., Taramelli, R., Acquati, F."RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model". International Journal of Oncology 49.6 (2016): 2637-2646.
Chicago
Turconi, G., Scaldaferri, D., Fabbri, M., Monti, L., Lualdi, M., Pedrini, E., Gribaldo, L., Taramelli, R., Acquati, F."RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model". International Journal of Oncology 49, no. 6 (2016): 2637-2646. https://doi.org/10.3892/ijo.2016.3763